Takeshi Tanoue

immunoHuMiX: A personalizable gut‐on‐chip model for unraveling human microbiome–immune interactions

Charlotte De Rudder, Kacy Greenhalgh, Joanna Bagińska, Camille Martin‐Gallausiaux et autres

Abstract An individual's immune status is an essential factor affecting the efficacy of microbiome‐based therapies. To enable representative studies of microbiome–immune system interactions, we developed protocols to facilitate the coculture of intestinal epithelial cells and human peripheral blood mononuclear cells (PBMCs) in …

lu, jp, nz, us, dk (code pays fourni par la source)

Microbiota-mediated induction of beige adipocytes in response to dietary cues

Takeshi Tanoue, Manabu Nagayama, Ayumi J. A. Roochana, Samuel Zimmerman et autres

Interactions between diet and the gut microbiota are fundamental to metabolic health, shaping energy balance and disease susceptibility1–5. However, the underlying mechanisms by which dietary and microbial factors converge to regulate host physiology remain unclear. Here we show that protein availability profoundly …

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Identification of specific microbiota members that induce beige fat biogenesis in response to dietary cues

Kenya Honda, Takeshi Tanoue, Manabu Nagayama, Ayumi Roochana et autres

jp, us, nl, il (code pays fourni par la source)

Commensal consortia decolonize Enterobacteriaceae via ecological control

Munehiro Furuichi, Takaaki Kawaguchi, Marie‐Madlen Pust, Keiko Yasuma-Mitobe et autres

Abstract Persistent colonization and outgrowth of potentially pathogenic organisms in the intestine can result from long-term antibiotic use or inflammatory conditions, and may perpetuate dysregulated immunity and tissue damage 1,2 . Gram-negative Enterobacteriaceae gut pathobionts are particularly recalcitrant to conventional antibiotic treatment …

jp, us (code pays fourni par la source)

Rationally-defined microbial consortia suppress multidrug-resistant proinflammatory Enterobacteriaceae via ecological control

Kenya Honda, Munehiro Furuichi, Takaaki Kawaguchi, Marie‐Madlen Pust et autres

jp, us (code pays fourni par la source)

Diet-mediated constitutive induction of novel IL-4+ ILC2 cells maintains intestinal homeostasis in mice

Wanlin Cui, Yuji Nagano, Satoru Morita, Takeshi Tanoue et autres

Group 2 innate lymphoid cells (ILC2s) expressing IL-5 and IL-13 are localized at various mucosal tissues and play critical roles in the induction of type 2 inflammation, response to helminth infection, and tissue repair. Here, we reveal a unique ILC2 subset in …

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Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome

Yoshinaga Kawano, Madeline Edwards, Yiming Huang, Angelina M. Bilate et autres

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Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

Yuko Sato, Koji Atarashi, Damian R. Plichta, Yasumichi Arai et autres

jp, us (code pays fourni par la source)

Generation of germ-free common marmosets

Takashi Inoue, Norio Okahara, Nobuyuki Okahashi, Kenya Sato et autres

jp (code pays fourni par la source)

Selected Clostridia Strains from The Human Microbiota and their Metabolite, Butyrate, Improve Experimental Autoimmune Encephalomyelitis

Laura Calvo‐Barreiro, Herena Eixarch, Thais Cornejo, Carme Costa et autres

Gut microbiome studies in multiple sclerosis (MS) patients are unravelling some consistent but modest patterns of gut dysbiosis. Among these, a significant decrease of Clostridia cluster IV and XIVa has been reported. In the present study, we investigated the therapeutic effect of …

es, jp (code pays fourni par la source)

Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation

Yoshihiro Ito, Takashi Sasaki, Youxian Li, Takeshi Tanoue et autres

Host-microbe interactions orchestrate skin homeostasis, the dysregulation of which has been implicated in chronic inflammatory conditions such as atopic dermatitis and psoriasis. Here, we show that Staphylococcus cohnii is a skin commensal capable of beneficially inhibiting skin inflammation. We find that Tmem79 …

jp (code pays fourni par la source)

Identification of unique bile acid-metabolizing bacteria from the microbiome of centenarians

Kenya Honda, Yuko Sato, Koji Atarashi, Damian R. Plichta et autres

jp, us, ar (code pays fourni par la source)