Shuo Xiao

Image-aware mixture-of-experts automates the detection of ovarian follicle rupture in a high-throughput ex vivo ovulation assay

Mahdi Babaei, Jiyang Zhang, Shuo Xiao, Yu Gan

An AI-based dynamic, image-aware Mixture-of-Experts (MoE) framework automates ex vivo ovulation detection and offers a highly accurate, scalable solution for studying the biology of ovulation, drug development, and reproductive toxicity testing.

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Excessive estrogenic environment during preimplantation disrupts embryo transport and development and differentially alters the transcriptomes of mouse oviduct and uterus

Shuo Xiao, Honglu Diao, Tong Zhou, Taylor E Martin et autres

Objective: Exposure to estrogenic endocrine-disrupting chemicals (EEDCs) has been associated with oviductal embryo retention, also called the tube-locking effect, which heightens the risk of infertility and ectopic pregnancy. Here we used preimplantation 17β-estradiol (E 2 ) exposure as a model to investigate …

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Proprotein convertase activity regulates cumulus-oocyte-complex matrix integrity and cumulus cell migration during ovulation via a GDF9-dependent mechanism

Caroline E. Kratka, Ruixu Huang, Jeffrey Pea, Robin M. Skory et autres

Cumulus cells have well-established roles early in ovulation but the key molecules that drive their behavior in later stages, leading to follicle rupture, remain underexplored. Here, we observed that inhibition of proprotein convertases (PCSKs) via a pan-inhibitor (PCI) impaired follicular rupture and …

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Wildland-Urban Interface Fires: Toxic Physicochemical Properties of Emitted Particulate Matter and Impacts on Lung Macrophages

Glen M. DeLoid, Lila Bazina, Leonardo D. Calderón, Georgios A. Kelesidis et autres

High Resolution Image Download MS PowerPoint Slide Due to the growth of urban areas in close proximity to wildlands, wildfires increasingly burn both biomass and man-made materials. The physicochemical properties of emitted particulate matter (PM) from such “wildland-urban interface (WUI)” fires may …

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Hormonal stimulation induces broader decidualization responses than cAMP alone in 3D human endometrial organoids

Shichao Liu, Jiyang Zhang, Tingjie Zhan, Qiang Zhang et autres

Abstract The human endometrium undergoes cyclic, hormone-driven remodeling that establishes a transient window of receptivity required for embryo implantation, placentation, and maintenance of pregnancy. Decidualization of endometrial stromal cells is a central component of this process and can be induced in vitro …

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Transporter-Mediated Uptake of Microcystin-LR in Human Trophoblasts: Regulation By Oxygen Concentration and Cell Fusion

Michael Jeffrey Campbell, Mokshitkumar Patel, Chenghui Jiang, Xia Wen et autres

Abstract Background Rising global temperatures and eutrophication are increasing the intensity and frequency of cyanobacterial harmful algal blooms that release toxins including microcystin-LR (MC-LR). MC-LR inhibits protein phosphatases in the human liver and brain, but its accumulation in the placenta is unclear. …

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Female reproductive impacts of emerging cyanobacterial harmful algal bloom toxins

Yingzheng Wang, Alexander LU, Kuhelika Mali, Samantha Cheron et autres

Harmful algal blooms (HABs), denoted by the excessive growth or 'bloom' of cyanobacteria, have increased in frequency, duration, and intensity worldwide over the past decades, primarily due to the rise in global temperature and nutrient enrichment. The blooms of cyanobacteria release various …

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AN EX VIVO POLYCYSTIC OVARIAN SYNDROME (PCOS) MODEL IDENTIFIES PROSTAGLANDIN E2 AS A KEY DRIVER OF PCOS-ASSOCIATED OVARIAN DISORDERS

Lauren Gibbs, Hongyi Xu, Shuo Xiao

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Clinical and economic outcomes of robotic-assisted, laparoscopic, and open liver resection in BCLC 0/A hepatocellular carcinoma: a nationwide cohort study

Xulin Liu, Jing Ying Yan, Zhancheng Qiu, Qiao Zhang et autres

BACKGROUND AND AIM: Hepatectomy remains the standard treatment for Barcelona Clinic Liver Cancer (BCLC) stage 0/A hepatocellular carcinoma (HCC). However, debates persist regarding the optimal surgical approach - robot-assisted (RALR), laparoscopic (LLR), or open liver resection (OLR) - due to differences in …

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DNA damage response signaling in oocytes from an oncofertility perspective

Jiyang Zhang, Yingnan Bo, Qiang Zhang, So‐Youn Kim et autres

The remarkable advances in cancer therapies significantly enhance the survival rates and longevity of cancer patients. Among childhood, adolescent, and young adult female cancer survivors, however, anti-cancer agents frequently cause primary ovarian insufficiency, early menopause, and infertility, primarily due to the depletion …

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A novel pathologic scoring system for predicting postoperative recurrence in BCLC stage 0-A hepatocellular carcinoma patients: a nationwide multicenter study

Jing Yan, Xulin Liu, Zhao Xiang Huang, Zhancheng Qiu et autres

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Peroxynitrite is key to Cylindrospermopsin-mediated MASLD to MASH progression via triggering TXNIP binding to NLRP3 and subsequent inflammasome activation

Punnag Saha, Dipro Bose, Subhajit Roy, Madhura More et autres

Harmful algal bloom (HAB) toxins are shown to be associated with Metabolic dysfunction-associated steatohepatitis (MASH) progression. Several studies link the HAB toxin microcystin to hepatic inflammasome activation, but the role of cylindrospermopsin (CYN) in Metabolic dysfunction-associated steatotic liver disease (MASLD) pathology remains …

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