Micky Bacchus

Integrating Oral THC:CBD Into Chronic Neuropathic Pain Management in Primary Care: A Two-Patient Observational Case Series

Camryn Butera, Tytianna Robinson, Samantha Temucin, Jade McNulty et autres

Introduction: Cannabis use among U.S. adults has increased substantially in recent years, and primary care physicians increasingly encounter patients using cannabis for chronic pain management. This case series describes two patients with chronic neuropathic pain participating in an observational study evaluating a …

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Paediatric cerebrospinal fluid immune profiling distinguishes paediatric-onset multiple sclerosis from other paediatric-onset acute neurological disorders

Diego A. Espinoza, Tobias Zrzavy, Gautier Bréville, Simon Thebault et autres

BACKGROUND: The cerebrospinal fluid (CSF) provides a unique glimpse into the central nervous system (CNS) compartment and offers insights into immune processes associated with both healthy immune surveillance as well as inflammatory disorders of the CNS. The latter include demyelinating disorders, such …

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Pediatric cerebrospinal fluid immune profiling distinguishes pediatric-onset multiple sclerosis from other pediatric-onset acute neurological disorders

Diego A. Espinoza, Tobias Zrzavy, Gautier Bréville, Simon Thebault et autres

The cerebrospinal fluid (CSF) provides a unique glimpse into the central nervous system (CNS) compartment and offers insights into immune processes associated with both healthy immune surveillance as well as inflammatory disorders of the CNS. The latter include demyelinating disorders, such as …

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GluCEST in Deep Gray Matter and Adjoining White Matter of pediatric-onset Multiple Sclerosis Brains using a Robust B1-calibration Approach

Dushyant Kumar, Ritobrato Datta, Micky Bacchus, Narayan Datt Soni et autres

Several proton magnetic resonance spectroscopy (1H-MRS) based studies have reported regional alterations of glutamate metabolism in both acute and chronic multiple sclerosis (MS) pathologies, including in normal appearing white matter and mixed tissues. Despite its well-established capability for detecting altered glutamate metabolism, …

An International Pediatric-Onset Opsoclonus-Myoclonus Ataxia Syndrome Registry and Clinical Research Network: Development, Progress, and Vision

L Kerr, Morgan E. Ryan, Ming Lim, Sarah Hearn et autres

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Neuroblastic Tumor Recurrence Associated With Opsoclonus Myoclonus Ataxia Syndrome Relapse a Decade After Initial Resection and Treatments

Micky Bacchus, David S. Anderson, Esther R. Berko, Lisa J. States et autres

Opsoclonus myoclonus ataxia syndrome (OMAS) is a rare disorder that causes significant neurodevelopmental sequelae in children. Approximately half of pediatric OMAS cases are paraneoplastic, typically associated with localized neuroblastic tumors. Since early persistence or relapse of OMAS symptoms is common even after …

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Social Networks in Pediatric-Onset Multiple Sclerosis are Associated with Less Negative Peer Pressure (P18-4.002)

Micky Bacchus, Wendy Vargas, Michael Glendinning, Seth Levin et autres

To analyze social networks in children with pediatric-onset MS (POMS) compared to healthy adolescents (HCs).

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Examining cognitive speed and accuracy dysfunction in youth and young adults with pediatric-onset multiple sclerosis using a computerized neurocognitive battery.

Emily Barlow-Krelina, Tracy L. Fabri, Julia O’Mahony, Ruben C. Gur et autres

OBJECTIVE: We evaluated performance on the Penn Computerized Neurocognitive Battery (PCNB), a tool assessing accuracy and response time across four cognitive domains, alongside the Symbol Digit Modalities Test (SDMT), a measure of processing speed commonly used in MS. We determined whether performance …

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Memory, processing of emotional stimuli, and volume of limbic structures in pediatric-onset multiple sclerosis

Tracy L. Fabri, Ritobrato Datta, Julia O’Mahony, Emily Barlow-Krelina et autres

OBJECTIVE: The limbic system is involved in memory and in processing of emotional stimuli. We measured volume of the hippocampus, amygdala, and thalamus, and assessed their relative contribution to episodic memory and emotion identification in POMS. METHOD: = 18.1 ± 4.6 years; …

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Fast automatic segmentation of thalamic nuclei from MP2RAGE acquisition at 7 Tesla

Ritobrato Datta, Micky Bacchus, Dushyant Kumar, Mark A. Elliott et autres

PURPOSE: Thalamic nuclei are largely invisible in conventional MRI due to poor contrast. Thalamus Optimized Multi-Atlas Segmentation (THOMAS) provides automatic segmentation of 12 thalamic nuclei using white-matter-nulled (WMn) Magnetization Prepared Rapid Gradient Echo (MPRAGE) sequence at 7T, but increases overall scan duration. …

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Fast automatic segmentation of thalamic nuclei from MP2RAGE acquisition\n at 7 Tesla

Ritobrato Datta, Micky Bacchus, Dushyant Kumar, Mark Ellıott et autres

Purpose: Thalamic nuclei are largely invisible in conventional MRI due to\npoor contrast. Thalamus Optimized Multi-Atlas Segmentation (THOMAS) provides\nautomatic segmentation of 12 thalamic nuclei using white-matter-nulled (WMn)\nMPRAGE sequence at 7T. Application of THOMAS to Magnetization Prepared 2 Rapid\nGradient Echo (MP2RAGE) sequence acquired at …

CSF Biomarkers of Disease Severity and Response to Nusinersen Treatment in Children with Spinal Muscular Atrophy (1971)

Giulia Fadda, Elizabeth Kichula, Micky Bacchus, Robert A. Brown et autres

To describe CSF levels of neurofilament-light chain (NfL), glial fibrillary acidic protein (GFAP) and Tau in a cohort of patients with a wide spectrum of disease severity and age at time of treatment initiation, both at baseline and following treatment with nusinersen.

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