Simon Thebault

Abnormal B-Cell Exosome Proapoptotic and Antiapoptotic Cargo in Multiple Sclerosis

Gautier Bréville, Ayman Rezk, S Weissman, Diego A. Espinoza et autres

Effect of mesenchymal stem cells on peripheral immune cells in multiple sclerosis: results from an international phase 2 clinical trial

Irene Schiavetti, Mark S. Freedman, Simon Thebault, Federico Ivaldi et autres

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Soluble c-Met correlates with NfL and GFAP levels in the CSF of patients with multiple sclerosis

Mahdia Benkhoucha, Gautier Bréville, Isis Senoner, Sylvie Chliate et autres

Introduction/Aims The hepatocyte growth factor (HGF)/c-Met pathway plays an important role in several inflammatory conditions, regulating phenotypic plasticity within both myeloid and lymphoid cell populations. c-Met was recently identified as a marker of a distinct subset of highly pro-inflammatory and pro-migratory CD4 …

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Best practice recommendations for laboratory analysis and reporting of cerebrospinal fluid oligoclonal banding and associated tests for multiple sclerosis (MS): a consensus report from the harmonized CSF analysis for MS investigation (hCAMI) subcommittee of the Canadian society of clinical chemists (CSCC)

Victoria Higgins, Michelle Parker, Basma Ahmed, Vipin Bhayana et autres

Cerebrospinal fluid (CSF) oligoclonal banding (OCB) analysis is an important component in the diagnosis of multiple sclerosis (MS). In the 2024 McDonald Criteria for MS diagnosis, CSF-specific OCB can support MS diagnosis, including in those with relapsing or progressive presentations, as well …

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Antibody-Negative Nivolumab-Induced Autoimmune Encephalitis: A Case Report and Review of Seronegative Presentations

Myriam Hamza, Hannah Randolph, Simon Thebault

Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but can provoke immune-related neurological complications, including autoimmune encephalitis (AIE). We report a 70-year-old woman who developed AIE after 11 months of adjuvant nivolumab for melanoma. Serial cerebrospinal fluid (CSF) studies revealed a lymphocytic …

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Paediatric cerebrospinal fluid immune profiling distinguishes paediatric-onset multiple sclerosis from other paediatric-onset acute neurological disorders

Diego A. Espinoza, Tobias Zrzavy, Gautier Bréville, Simon Thebault et autres

BACKGROUND: The cerebrospinal fluid (CSF) provides a unique glimpse into the central nervous system (CNS) compartment and offers insights into immune processes associated with both healthy immune surveillance as well as inflammatory disorders of the CNS. The latter include demyelinating disorders, such …

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Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis

Maxime Bigotte, Adam M.R. Groh, Elia Afanasiev, Vincent Kam Wai Wong et autres

Multiple sclerosis (MS) is a disorder of the CNS in which autoreactive immune cells migrate through a damaged blood-brain barrier, resulting in focal demyelinating lesions. Beyond focal lesions, there are also diffuse 'surface-in' gradients of pathology in MS, wherein damage is most …

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B-102 Harmonizing cerebrospinal fluid analysis for multiple sclerosis investigation: An update from the hCAMI subcommittee of the Canadian Society of Clinical Chemists (CSCC)

Victoria Higgins, Daniel R. Beriault, Michelle Parker, Vipin Bhayana et autres

Abstract Background Laboratory tests are increasingly important for diagnosing multiple sclerosis (MS). Cerebrospinal fluid (CSF) laboratory testing, including detection of CSF oligoclonal bands (OCB), aids in the diagnosis of MS but significant variability in reporting practices across Canadian clinical laboratories has been …

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Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis pathophysiology

Maxime Bigotte, Adam M.R. Groh, Elia Afanasiev, Kevin Lançon et autres

Abstract Background Multiple sclerosis is a neurodegenerative autoimmune disorder of the central nervous system (CNS) in which autoreactive immune cells migrate through a damaged blood brain barrier, resulting in focal demyelinating lesions of both the white and grey matter. Of increasing interest …

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Blood biomarkers for predicting disability worsening in progressive multiple sclerosis: a multinational, individual participant-level analysis

Ahmed Abdelhak, Franziska Bachhuber, Kiarra Ning, Pascal Benkert et autres

BACKGROUND AND OBJECTIVES: Biologically informative markers like glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) may help predict confirmed disability worsening (CDW) in multiple sclerosis (MS). However, data on the prognostic value of their blood concentrations in progressive MS (PMS) …

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Role of soluble biomarkers in treating multiple sclerosis and neuroinflammatory conditions

Gauruv Bose, Simon Thebault, Giulia Fadda, John Brooks et autres

Multiple sclerosis (MS) is a complex, chronic immune-mediated disease characterized by acute and progressive inflammatory damage of the central nervous system. MS manifests clinically with unpredictable neurological symptoms from focal inflammatory attacks as well as gradual neurodegeneration which contribute significantly to long-term …

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The utility of serum neurofilament light chain in MOGAD: Current insights and future directions

Simon Thebault, Ronald A. Booth, John Brooks, Carolina Rush et autres

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