Examining cognitive speed and accuracy dysfunction in youth and young adults with pediatric-onset multiple sclerosis using a computerized neurocognitive battery.
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Le résumé fourni par la source
OBJECTIVE: We evaluated performance on the Penn Computerized Neurocognitive Battery (PCNB), a tool assessing accuracy and response time across four cognitive domains, alongside the Symbol Digit Modalities Test (SDMT), a measure of processing speed commonly used in MS. We determined whether performance decrements are more likely to be detected on measures of accuracy versus response time in pediatric-onset multiple sclerosis (POMS). METHODS: Performance on the SDMT, accuracy on PCNB tests belonging to four domains (executive function, episodic memory, complex cognition, social cognition), and response time on the PCNB were compared for 65 POMS patients (age range: 8-29 years) and 76 healthy controls (HCs) by ANCOVA. Associations between the Overall PCNB score and SDMT were examined for both groups, and their agreement in classifying impairment was assessed using Cohen's kappa. RESULTS: POMS patients (age at testing = 18.3 ± 4.0 years; age at POMS onset = 14.9 ± 2.3 years) demonstrated reduced accuracy relative to HCs on tests of working memory, attention/inhibition, verbal memory, and visuospatial processing, after adjusting for response time (p ≤ .002). Patients demonstrated slower overall response time on the PCNB (p = .003), while group differences on the SDMT did not meet significance (p = .03). Performance on the PCNB and SDMT were correlated (MS: r = 0.43, HC: r = 0.50, both p < .001), however, the degree of agreement for impairment was minimal (k = 0.22, p = .14). CONCLUSION: Specific cognitive deficits exist independently of slowed information processing speed in POMS, and may represent more significant areas of dysfunction. Delineation of accuracy and response time in neuropsychological assessment is important to identify areas of cognitive deficit in POMS. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Examining cognitive speed and accuracy dysfunction in youth and young adults with pediatric-onset multiple sclerosis using a computerized neurocognitive battery.
- Date Crossref
- 01/05/2021
- Éditeur
- American Psychological Association (APA)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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York University Department of Psychology pays non établi dans la noticeUniversité ou école supérieure
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Hospital for Sick Children Neurosciences and Mental Health Program pays non établi dans la noticeÉtablissement de santé
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University of Pennsylvania Penn-CHOP Lifespan Brain Institute pays non établi dans la noticeUniversité ou école supérieure
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Children's Hospital of Philadelphia Division of Neurology pays non établi dans la noticeOrganisme public
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University of Manitoba pays non établi dans la noticeUniversité ou école supérieure
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Max Rady College of Medicine Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Psychology — York University, Neurosciences and Mental Health Program — Hospital for Sick Children et Penn-CHOP Lifespan Brain Institute — University of Pennsylvania, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.