Jianguo Lai

Global, regional, and national burden of breast cancer among females, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023

Kayleigh Pavitra Bhangdia, Miranda L May, Jonathan M Kocarnik, Natalie R. Pritchett et autres

Cell-in-cell structures and cancer metastasis

Yuchen Cao, Jianing Du, Jianguo Lai, Chunjun Liu

Cell-in-cell (CIC) structures, characterized by one cell engulfing another, play a paradoxical role in cancer metastasis. This review synthesizes their dual nature: while CIC can suppress metastasis by eliminating aberrant cells or activating immune responses, it also drives tumor progression through clonal …

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MRI-Based Deep Learning Guides Multi-Omics Discovery of NBPF4 as a Therapeutic Target for Breast Cancer Lymph Node Metastasis

Dianqi Cai, Haoxuan Huang, Zijun Chen, Chao Zhu et autres

Deep learning models are increasingly used to analyze medical images, but their “black box” nature makes it hard to understand the underlying biology and slows down the development of targeted treatments. To tackle this, we built a multi-step approach that combines deep …

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Lymph Node Metastasis-Associated Spatiotemporal Mapping of the TFF3-Linked Niche in Breast Cancer: Integrating Radiogenomic Signatures with Immune-Ecosystem Remodeling

Chao Zhu, Haoxuan Huang, Yuchen Cao, Gengxi Cai et autres

Primary breast cancer (PBC) with axillary lymph node metastasis (ALNM+) is associated with distinct clinical outcomes, including reduced survival (The Cancer Genome Atlas/Foshan cohorts, P < 0.05) and an attenuated response to anti-programmed cell death protein 1 antibody/anti-programmed death-ligand 1 antibody (anti-PD-1/anti-PD-L1) …

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The global, regional, and national disease burden of breast cancer attributable to behavioral risks from 1990 to 2021 and projections to 2035: a systematic analysis of the Global Burden of Disease Study 2021

Ye Fu, Xiaojing Chen, Yuchen Cao, Z. You et autres

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0208 Evaluating the incidence and prevalence of perioral dermatitis in the United States: A population-level study

Christopher J Thang, David Gárate, Jianguo Lai, Georgy Golovko et autres

Arginase 1 genetic variation is associated with the risk of vascular complications in type 2 diabetes

Xiangdong Chen, Li Li, Shujuan Ma, Jianguo Lai et autres

Objective This study aims to explore the association between arginase 1 (ARG1) genetic variation and susceptibility to type 2 diabetes (T2DM) vascular complications, a primary cause of morbidity and mortality in diabetics.Methods ARG1, a risk gene for cardiovascular disease, was identified from …

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Identification of biomarker associated with Trop2 in breast cancer: implication for targeted therapy

Jianguo Lai, Shuxuan Deng, Jiyuan Cao, Yongqi Ren et autres

PURPOSE: Trop2, a cell membrane glycoprotein, is overexpressed in almost all epithelial cancers. This study aimed to explore the mutational characteristics and significance of Trop2 in breast cancer (BC). METHODS: Patients diagnosed with BC (n = 77) were enrolled to investigate expression …

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Abstract PO3-08-09: Unique molecular signatures of germline mutations in low expression of human epidermal growth factor receptor 2 (HER2) breast cancer

Ning Liao, Weiqi Zhang, Liangqiu Liu, Wendy Yi-Ying Wu et autres

Abstract Background: Overexpression of human epidermal growth factor receptor 2 (HER2) in breast cancer (BC) is associated with lower survival and higher risk of disease recurrence. A new subtype of HER2-low BC which has been proposed from several studies demonstrates that HER2-low …

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Circular RNA circTATDN3 promotes the Warburg effect and proliferation in colorectal cancer

Jiatong Lin, Wenhui Zhong, Zejian Lyu, Jingwen Peng et autres

As one of the key metabolic enzymes in the glycolytic pathway, lactate dehydrogenase A (LDHA) might be linked to tumor proliferation by driving the Warburg effect. Circular RNAs (circRNAs) are widely implicated in tumor progression. Here, we report that circTATDN3, a circular …

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Correction for: A novel six-microRNA-based model to improve prognosis prediction of breast cancer

Jianguo Lai, Hongli Wang, Zihao Pan, Fengxi Su

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Single-cell and whole-transcriptome sequencing of lymph node metastasis-related gene signature: A large-scale pan-cancer cohort, machine learning and experimental study: [RETRACTED]

Jianguo Lai, Yan He, Xiaoqing Cai, Yuchen Cao et autres

Background: Lymph node metastasis (LNM) is an independent prognostic factor in numerous types of cancer. Therefore, a LNM-related gene-based nomogram may precisely predict survival and drug sensitivity, and reveal the mechanism underlying LNM. Materials and Methods: Gene sequencing profiles of pan-cancer data …

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