Ning Liao

Benmelstobart plus antiangiogenic therapy vs chemotherapy for metastatic triple-negative breast cancer: phase III trial

Jiayu Wang, Quchang Ouyang, Zhihong Wang, Qingyuan Zhang et autres

This open-label phase III trial assessed a chemotherapy-free regimen for recurrent/metastatic triple-negative breast cancer (TNBC). Patients were 1:1 randomized to benmelstobart plus anlotinib or nab-paclitaxel monotherapy, stratified by prior taxane exposure, liver and brain metastases. Planned enrollment was 322, yet recruitment was …

cn (code pays fourni par la source)

Ultrasound-Guided, Indocyanine Green-Directed Robot-Assisted Breast Surgery for Benign Tumours

Nanqiu Liu, Guochun Zhang, Chongyang Ren, Jiyuan Cao et autres

OBJECTIVE: To compare the feasibility, safety, and cosmetic satisfaction of ultrasound-guided, indocyanine green (ICG)-assisted robotic lumpectomy with open lumpectomy for benign breast tumours. STUDY DESIGN: A retrospective cohort study. Place and Duration of the Study: Department of Breast Surgery, Guangdong Provincial People's …

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Evaluation of HER2 status and characteristics by next-generation sequencing in breast cancer

Nanqiu Liu, Chongyang Ren, Yongqi Ren, Shuxuan Deng et autres

Background: Although next-generation sequencing (NGS) has been widely used to provide comprehensive somatic mutational information for individualized therapy in breast cancer patients, whether or not it could reliably evaluate HER2 status to guide targeted therapy when compared to the current IHC/FISH standard …

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Pathogenic germline variants associated with different HER2 expression among breast cancer patients

Yongqi Ren, Li Cao, Chongyang Ren, Nanqiu Liu et autres

PURPOSE: Germline mutations were evaluated in 530 Chinese breast cancer (BC) patients with different HER2 expression status plus 98 patients with atypical ductal hyperplasia or a breast cancer family history. METHODS: DNA extracted from blood samples was analyzed with a next generation …

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Ultrasound-guided, indocyanine green-directed robot-assisted surgery for breast cancer with negative margins: A single center study

Ning Liao, Nanqiu Liu, Guochun Zhang, Chongyang Ren et autres

OBJECTIVE: This pilot study evaluated the feasibility of a novel technique combining ultrasound-guided and indocyanine green (ICG) intra-tumoral injection with robot-assisted surgery to enable accurate local excision (lumpectomy) for breast cancer. BACKGROUND: Robot-assisted breast surgery has been used for nipple-sparing mastectomy for …

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The global cancer crisis: a review of growing burden, deepening inequality and initiatives for prevention and early detection

Charles M. Balch, Ning Liao, Denis S C Lam, Jeffrey N Weitzel et autres

Cancer constitutes one of the most urgent global health crises, with over 20 million new cases diagnosed annually worldwide, claiming 10 million lives. This devastating burden disproportionately affects vulnerable populations: 75% of cancer deaths occur in low- and middle-income countries despite these …

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Spatial Chromatin Accessibility Analysis of Intratumor Heterogeneity in Breast Cancer

Yingying Qian, Miao Zhu, Chongyang Ren, Yeyong Zhou et autres

Intratumoral heterogeneity (ITH) is a major driver of mortality in breast cancer (BC) patients and a critical factor in the variable therapeutic outcomes observed in BC treatment. Understanding the mechanisms underlying ITH is essential for advancing both clinical and basic BC research. …

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Aloin Suppresses Cancer Cell Growth via Autophagy-Promoted NEDD8 Deneddylation to Target GPX4 for Ferroptosis Induction

Baochun Lu, Ning Liao, Yang Wang, Zhi Yang et autres

ETER901: A randomized, open-label, phase III trial of anlotinib in combination with anti-PD-L1 antibody benmelstobart (TQB2450) versus nab-paclitaxel in first-line treatment of recurrent or metastatic triple-negative breast cancer.

Jiayu Wang, Binghe Xu, Quchang Ouyang, Zhihong Wang et autres

1104 Background: Recurrent or metastatic triple-negative breast cancer (TNBC) represents an aggressive malignancy with unfavorable prognoses. Benmelstobart (TQB2450) is a humanized monoclonal antibody targeting PD-L1, and anlotinib (ALTN) is an anti-angiogenic oral multi-target tyrosine kinase inhibitor. Herein, we present the findings of …

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Pathogenic germline variants in breast cancer patients associated with different HER2 expression levels.

Ning Liao, Jiayan Wu, Guochun Zhang, Jeffrey N. Weitzel et autres

e12543 Background: Germline pathogenic/likely pathogenic variants (PV) were evaluated in 530 Chinese breast cancer patients and 98 patients with atypical ductal hyperplasia or a family history of breast cancer using NGS-based analysis. Methods: An NGS-based multigene panel was used to identify germline …

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Feasibility of robot-assisted breast surgery using ultrasound guided indocyanine green injections for breast cancer lumpectomy with negative margins

Ning Liao, Na Liu, Guozhi Zhang, Chongyang Ren et autres

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Promoting precision health using fitness wearable and apps among breast cancer survivors: Protocols of a smart health management trial

Qin Yuan, John Oginni, Ning Liao, Hui He et autres

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