Christopher Fernandez‐Prada

Protocol for telomere-to-telomere assembly of Borrelia genomes using a hybrid method

Atia B. Amin, Ana Victoria Ibarra‐Meneses, Mathieu Blanchette, Christopher Fernandez‐Prada et autres

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Qualitative Risk Assessment of Infectious Agents Associated with Canine Importation into Canada, 2023–2024

Vanessa May Leung, Jada Chiasson, Victoria Patterson, Anjali Narasimhan et autres

Dog importation into Canada has grown substantially since the early 2010s, and concerns have been raised regarding the potential introduction of infectious agents. We conducted a qualitative risk assessment of infectious agents associated with canine importation into Canada. We adapted international risk …

Occurrence of Trichinella spp. infestations in black bears in Quebec, Canada

Simon Krückemeier, Christopher Fernandez‐Prada, Marie-Odile Benoit-Biancamano

Trichinella spp. are parasitic nematodes with a worldwide distribution that infect mammals, birds, and reptiles. Trichinella is composed of at least 13 taxa; the latest taxon, T13, was identified in wolverines in northwestern Canada in 2020. Trichinella is of public health importance …

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Safeguarding Canadian pets and humans: A call to strengthen regulations for importing companion animals

Christopher Fernandez‐Prada, Victoria Wagner, Emily Jenkins

Companion animals are more and more mobile and global translocation of parasites and other pathogens is increasingly recognized as a risk to animal and human health, as well as to international trade.Canadian regulations for importation of pets are lax, with only rabies …

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Safeguarding Canadian pets and humans: A call to strengthen regulations for importing companion animals.

Christopher Fernandez‐Prada, Victoria Wagner, Emily Jenkins

, are inadvertently imported along with pets. The objective of this article is to provide a timely review of the current regulatory situation in Canada, describe recent examples of foreign animal pathogens, including drug-resistant parasites, being brought into Canada, and provide expert …

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Pioneer factor IRF1 unlocks latent enhancers to rewire chromatin and immunometabolism in inflammatory macrophages

Jose-Mauricio Ayala, Rebecca Bellworthy, Mathieu Mancini, Ana Victoria Ibarra‐Meneses et autres

ABSTRACT Macrophages undergo extensive chromatin and metabolic remodeling to mount effective inflammatory responses. Here, we identify Interferon Regulatory Factor 1 (IRF1) as a pioneer factor that orchestrates these processes during IFNγ-driven macrophage activation. Integrative ATAC-seq, ChIP-seq, Hi-ChIP, and nascent RNA-seq demonstrated that …

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Telomere-to-telomere assembly detects genomic diversity in Canadian strains of Borrelia burgdorferi

Atia B. Amin, Ana Victoria Ibarra‐Meneses, Simon Gagnon, Georgi Merhi et autres

Borrelia burgdorferi, the bacteria causing Lyme disease, has a complex genome comprising a linear chromosome and multiple linear and circular plasmids. The atypical hairpin telomeres and the highly paralogous plasmids complicate genome assembly. We develop a genome assembly pipeline using both long …

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Predicting current and future areas of ecological suitability for Lutzomyia longipalpis sensu lato in the Americas

Sydney DeWinter, Grace K Nichol, Christopher Fernandez‐Prada, Amy L. Greer et autres

Leishmania infantum is one of the etiologic agents of leishmaniases in mammals. In the Americas, numerous sand fly species within the Lutzomyia genus drive Leishmania spp. transmission, such as the species complex Lutzomyia longipalpis sensu lato. It remains unknown if climatic changes …

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Correlates of Dietary Changes During COVID-19 in Immunosuppressed Individuals and Their Relatives: Alignment with Nutritional Recommendations

Manila Sophasath, Audrey Plante, Chantal Bémeur, Crystèle Hogue et autres

Background/Objectives: The sanitary measures implemented during the COVID-19 pandemic, although essential for limiting the virus propagation, hindered healthy behaviours and negatively affected mental health and quality of life. In immunosuppressed individuals at higher risk of COVID-19 complications, these measures may have influenced …

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p -Alkoxy-Substituted Anisomycins with Potent Anti-Trypanosomiasis Activity and Expanded Modes of Action

Kajumee Bora Bhowal, Anh Minh Thao Nguyen, Ana Victoria Ibarra‐Meneses, Andressa Brito Lira et autres

Abstract Neglected tropical diseases caused by trypanosomatid parasites present a major public healthcare issue, partly due to emerging resistance. Attachment of ω-alkynyl chains characteristic of the lipid tails of antiparasitic peptides to the p-position of anisomycin gave ethers exhibiting potent activity, rivalling …

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Telomere-to-telomere assembly detects genomic diversity in Canadian strains of Borrelia burgdorferi

Atia B. Amin, Ana Victoria Ibarra‐Meneses, Simon Gagnon, Georgi Merhi et autres

Abstract Borrelia burgdorferi, the bacteria causing Lyme disease, has a complex genome comprising a linear chromosome and a combination of linear and circular plasmids. The atypical hairpin structure at the telomere of linear replicons and the highly paralogous plasmids make the genome …

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Publisher Correction: Assessing current and future areas of ecological suitability for Lutzomyia shannoni in North America

Sydney DeWinter, Grace K Nichol, Christopher Fernandez‐Prada, Amy L. Greer et autres

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