Lúcia Emanueli Schimith

Comparative Effects of Quercetin and its α- and β-D-glucoside Derivatives in LPS-Stimulated C6 Astroglial Cells

Michele Goulart dos Santos, Tainá Guillante, Rafael Felipe de Aguiar, Marcelo Augusto Germani Marinho et autres

Neuroinflammation is a response of the central nervous system to injury, infection, or disease, involving the activation of glial cells and the release of cytokines and reactive species. When sustained or dysregulated, it contributes to the progression of neurological disorders. Quercetin (Que) …

br, fr (code pays fourni par la source)

Glycosylation Matters: Network Pharmacology-Based and Molecular Docking Analysis of Resveratrol Glycosylated Derivatives on Parkinson’s Disease

Lúcia Emanueli Schimith, Elvis Martis, Ana Luíza Muccillo-Baisch, Corinne André‐Miral et autres

validation remains necessary.

br, fr (code pays fourni par la source)

Effects of Polydatin on Pentylenetetrazol-Induced Seizures in Zebrafish Larvae

Fernanda Barros de Miranda, Lúcia Emanueli Schimith, Dennis Guilherme da Costa Silva, Camila de Oliveira Vian et autres

Background/Objectives: Epilepsy is a common neurological condition characterized by the occurrence of a seizure. It affects around 50 million individuals worldwide, and despite the large quantity of anti-seizure medications available, 30% of epileptic patients still suffer from seizures. Therefore, it is necessary …

br (code pays fourni par la source)

Pharmacokinetic Prediction and Cytotoxicity of New Quercetin Derivatives

Michele Goulart dos Santos, Marie Demonceaux, Lúcia Emanueli Schimith, Marine Goux et autres

Quercetin (QUE) possesses various pharmacological properties; however, its low bioavailability and solubility hinder its beneficial effects. Enzymatic glycosylation has been explored to improve these aspects. In the present study, we used a sucrose phosphorylase variant to catalyze the regioselective transglucosylation of QUE, …

br (code pays fourni par la source)

Pharmacokinetic prediction and cytotoxicity of new quercetin derivatives

Michele Goulart dos Santos, Marie Demonceaux, Lúcia Emanueli Schimith, Marine Goux et autres

Quercetin (QUE) possesses various pharmacological properties; however, its low bioavailability and solubility hinder its beneficial effects. Enzymatic glycosylation has been explored to improve these aspects. In the present study, we used a sucrose phosphorylase variant to catalyze the regioselective transglucosylation of QUE, …

fr, br, us (code pays fourni par la source)

Omega‐3 polyunsaturated fatty acids and Parkinson's disease: A systematic review of animal studies

Barbara da Silva Alves, Lúcia Emanueli Schimith, André Brito da Cunha, Cristiana Lima Dora et autres

Parkinson's disease (PD) is the second most common neurodegenerative disorder. The primary pathological features of PD include the presence of α-synuclein aggregates and Lewy bodies, mitochondrial dysfunction, oxidative stress, and neuroinflammation. Recently, omega-3 fatty acids (ω-3 PUFAs) have been under investigation as …

br (code pays fourni par la source)

Course on Breeding, Handling, and Experimental Procedures of Zebrafish (Danio rerio): Training, Refinement, Paradigm Shift, and Dissemination of Knowledge from Brazil to the World.

Tony Leandro Rezende da Silveira, Mateus Tavares Kütter, Bruna Félix da Silva Nornberg, Marcela Meirelles et autres

Currently, in Brazil, all researchers involved in animal experimentation must undergo training in laboratory animal science to stay updated on biology, methodology, ethics, and legal considerations related to the use of animals. The training program presented in this study not only aims …

br (code pays fourni par la source)

Preclinical toxicological assessment of polydatin in zebrafish model

Lúcia Emanueli Schimith, Vitória Machado da Silva, Dennis Guilherme da Costa-Silva, Linda Karolynne Seregni Monteiro et autres

Polydatin (3,4’,5-trihydroxystilbene-3-β-D-glucoside, piceid), a natural stilbenoid found in different plant sources, has gained increasing attention for its potential health benefits. However, prior to its widespread adoption in human therapeutics and consumer products, a comprehensive investigation of its toxicological effects is crucial. In …

br, fr (code pays fourni par la source)

Natural antioxidant nanoparticles in neuroprotection

Mariana Appel Hort, Gustavo Richter Vaz, Lúcia Emanueli Schimith, Michele Goulart dos Santos et autres

br (code pays fourni par la source)

List of contributors

Raquel Abalo, Eman A. R. Abdelghffar, Yasmin M. Abdelkhalek, Sabrina Acuña et autres

es, Égypte, uy, Nigéria, us, pk, ae, br, in, tr (code pays fourni par la source)

Enzymatic Synthesis, Characterization and Molecular Docking of a New Functionalized Polyphenol: Resveratrol-3,4’-⍺-Diglucoside

Marie Demonceaux, Marine Goux, Lúcia Emanueli Schimith, Michele Goulart dos Santos et autres

fr, br (code pays fourni par la source)

Enzymatic synthesis, characterization and molecular docking of a new functionalized polyphenol: Resveratrol-3,4′-⍺-diglucoside

Marie Demonceaux, Marine Goux, Lúcia Emanueli Schimith, Michele Goulart dos Santos et autres

Transglucosylation of resveratrol by the Q345F variant of sucrose phosphorylase from Bifidobacterium adolescentis (BaSP) was extensively studied during the last decade. Indeed, Q345F is able to catalyze the synthesis of resveratrol-3-O-⍺-D-glucoside (RES-3) with yield up to 97% using a cost-effective glucosyl donor, …

fr, br (code pays fourni par la source)