Kai Shen

Glibenclamide attenuates osteoarthritis by suppressing NLRP3 inflammasome activation in synovial macrophages through the MAPK pathway

Jinrong Ni, Hao Zhou, Kai Shen, Hongtao Xu et autres

BACKGROUND: Osteoarthritis (OA) is a chronic joint disorder characterized by progressive cartilage degeneration, synovial inflammation, and abnormal subchondral bone remodeling. Synovial macrophages play a key role in regulating joint inflammation and cartilage destruction. Glibenclamide (Gb) is a commonly used hypoglycemic drug that …

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Chondrocyte-targeting hydrogel loaded with puerarin limits osteoarthritis development by maintaining mitochondrial function

Yunpeng Wan, Kai Shen, Jishi Jiang, Dan Li et autres

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Venetoclax plus decitabine, cytarabine, aclarubicin, and G‐ CSF in adults with newly diagnosed acute myeloid leukemia: A multicenter, retrospective study

Ying Zhang, Kun Yang, Yong Guo, Jin Rao et autres

This multicenter, retrospective study evaluated the efficacy and safety of the venetoclax plus decitabine, cytarabine, aclarubicin, and granulocyte colony-stimulating factor (VD-CAG) regimen in newly diagnosed acute myeloid leukemia (ND-AML) patients aged 18-60. The analysis included, but was not limited to, the composite …

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Real world outcomes of zanubrutinib monotherapy for CLL/SLL focusing on treatment discontinuation and BTKi switching: A single center retrospective analysis

Kai Shen, Chenlu Yang, Jinrong Yang, He Li et autres

Abstract Introduction: Zanubrutinib as a second generation bruton tyrosin kinase inhibitor (BTKi) has become the standard of care for both frontline and relapsed/refractory chronic lymphocytic leukemia (CLL) /small lymphocytic lymphoma (SLL) in China regardless of TP53 mutation or fitness status. As it …

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Efficacy and safety of orelabrutinib monotherapy in patients with chronic lymphocytic leukemia: A retrospective real-world study

Kai Shen, Chenlu Yang, J.T. Yang, He Li et autres

Abstract Introduction: Chronic lymphocytic leukaemia (CLL), a hematologic malignancy of B cells, is one of the most frequent types of leukemia (Lancet 2024:404:694-706). Recently, Bruton's tyrosine kinase inhibitors (BTKis) have become a standard first-line treatment for patients (pts) with CLL, showing remarkable …

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Real-world outcomes and a novel prognostic assessment model for high-risk acute promyelocytic leukemia receiving all-trans retinoid acid and arsenic trioxide dual induction based on lasso-cox regression

Kai Shen, Chenlu Yang, Hongbing Ma

Abstract Introduction: High-risk (HR) acute promyelocytic leukemia (APL) remains a challenge due to early death (ED) and relapse. All-trans retinoic acid (ATRA) and arsenic trioxide (ATO) have revolutionized the APL treatment. Although the first results from the phase 3 APOLLO trial suggested …

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Performance of Large Language Models in Diagnosing Rare Hematologic Diseases and the Impact of Their Diagnostic Outputs on Physicians: Combined Retrospective and Prospective Study

Hongbin Yu, Tian Chen, Xin Zhang, Yunfan Yang et autres

Background: Rare hematologic diseases are frequently underdiagnosed or misdiagnosed due to their clinical complexity. Whether new-generation large language models (LLMs), particularly those using chain-of-thought reasoning, can improve diagnostic accuracy remains unclear. Objective: This study aimed to evaluate the diagnostic performance of new-generation …

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Emergence of an XDR Klebsiella pneumoniae ST5491 strain co-harboring NDM-5, MCR-1.1, tmexCD1-toprJ1, and a novel plasmid carrying CTX-M-15

Yinfei Fang, Xiangchen Li, Zhaoxia Wu, Fang Ye et autres

Objective The rapid emergence of antimicrobial resistance (AMR) in Klebsiella pneumoniae poses a significant global health threat. The study aimed to analyze and describe the genomic architecture and resistance mechanisms of an extensively drug-resistant (XDR) K. pneumoniae isolate, KP09, by focusing on …

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Integration of anti-PD-1 antibody into chemotherapeutic regimens improved the outcome of aggressive NK cell leukemia: a single-center retrospective real-world analysis

Kai Shen, Yi‐Jen Liao, Yang Dai, Jie Ji et autres

Background: Aggressive natural killer (NK) cell leukemia (ANKL) is a rare NK cell neoplasm associated with Epstein-Barr virus (EBV) infection. Programmed cell death protein 1 (PD-1) blockade, which is successful in extranodal NK/T-cell lymphoma and EBV-related hemophagocytic lymphohistiocytosis, is considered to have …

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Physicochemical characterization and protective effects of raw and nine-steamed Polygonatum cyrtonema polysaccharides on cyclophosphamide-induced immunosuppression in mice

Weiguang Luo, Xiuwei Li, Chenxi Zhang, Kai Shen et autres

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MiR-147b-3p promotes osteogenesis by targeting NDUFA4 and PI3K/AKT pathway

Yuanyuan Guo, Kai Shen, Zhenlin Li, Yang Luo

BACKGROUND: Osteoporosis (OP) is a progressive metabolic bone disease characterized by impaired bone microarchitecture, decreased bone strength, and dysregulated bone remodeling, leading to an increased risk of fractures. Among osteoporotic fractures, osteoporotic vertebral compression fractures (OVCF) are the most common and can …

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The clinical characteristics and implications of acute kidney injury during induction therapy for acute promyelocytic leukemia

Kai Shen, Chenlu Yang, Jie Huang, Shuai Xiao et autres

Background: Dual induction with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has made acute promyelocytic leukemia (APL) a curable disease. However, differentiation syndrome (DS) can be a life-threatening complication of induction therapy. It is considered to result from a severe systemic …

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