Yunpeng Wan

Baicalein limits subchondral bone lesions via AMPKα/BECN1 activation in osteoarthritis osteoblast

Yunlei Zhai, Pinghui Zhou, Li Dan, Mingming Ma et autres

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Chondrocyte-targeting hydrogel loaded with puerarin limits osteoarthritis development by maintaining mitochondrial function

Yunpeng Wan, Kai Shen, Jishi Jiang, Dan Li et autres

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TMEM106A deficiency in microglia attenuates functional recovery after spinal cord injury by exacerbating neuroinflammation

Bin Zhu, Ya Ding, Shuai Yu, Jiajun Cai et autres

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Identification of a Novel Mitochondrial-Related Gene Signature for BMSCs in Osteoporosis Combining Single-Cell and Bulk Transcriptome Data

Dan Li, Di Cui, Yunpeng Wan, Pinghui Zhou et autres

Osteoporosis (OS) is a prevalent skeletal disorder characterized by reduced bone mass and increased fracture risk, often linked to compromised functions of bone mesenchymal stem cells (BMSCs). Mitochondrial dysfunction and aberrant mitophagy are implicated in OS pathogenesis. This study aimed to identify …

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The impact of diabetes mellitus on tendon pathology: a review

Jian Xu, Jinbo Wang, Yuncong Ji, Yanlong Liu et autres

Diabetes is one of the most common metabolic diseases worldwide, leading to complications, mortality, and significant healthcare expenditures, which impose a substantial social and financial burden globally. A diabetic environment can induce metabolic changes, negatively affecting tendon homeostasis, leading to alterations in …

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The initial slab rollback of Neo-Tethys Ocean: Constrain from Gongga adakitic rocks and enclaves in the late Cretaceous

Zhenzhen Wang, Zhidan Zhao, Yunpeng Wan, Zhang Li et autres

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Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis

Yunpeng Wan, Kai Shen, Hou–Yong Yu, Weimin Fan

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Clinical Study of Correlation Between Osteoporosis and Osteoarthritis of Knee Joint Using Gold Nanomaterial Contrast Agent

Dan Li, Yunpeng Wan, Yongjin Sun, Xing Wu

The relationship between osteoporosis (OP) and knee osteoarthritis (OA) was studied using gold nanomaterial (GNP) contrast agent from the imaging and clinical perspectives. Patients were divided into the OA and OP comorbidity group (experimental), OA group (positive control), and OP group (negative …

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LncRNA NEAT1 promotes proliferation of chondrocytes via down‐regulation of miR‐16‐5p in osteoarthritis

Dan Li, Yongjin Sun, Yunpeng Wan, Xing Wu et autres

BACKGROUND: Non-coding RNAs are endogenous regulators of gene expression that have been implicated in the pathogenesis of various diseases, including osteoarthritis (OA). Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) and miR-16-5p are up-regulated in OA tissues; however, their functions have …

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15-Lipoxygenase-1 in osteoblasts promotes TGF-β1 expression via inhibiting autophagy in human osteoarthritis

Yunpeng Wan, Yunxiang Lv, Lei Li, Zongsheng Yin

BACKGROUND: 15-Lipoxygenase-1 (15-LOX-1) belongs to the lipoxygenase family involved in the inflammatory response and pathological process of various diseases, including osteoarthritis (OA). The overexpression of TGF-β1 in osteoblasts leads to abnormal changes in subchondral bone structure, eventually causing OA. However, the pathogenesis …

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Elevated levels of 15-lipoxygenase-1 contribute to the abnormal phenotypes of osteoblasts in human osteoarthritis

Yunpeng Wan, Dan Li, Yunxiang Lv, Minmin Wu et autres

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Abnormal thyroid hormone receptor signaling in osteoarthritic osteoblasts regulates microangiogenesis in subchondral bone

Lei Li, Meng Li, Yiqun Pang, Jun Wang et autres

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