Zhenkang Li

TXI Raises Detection of Non-Neoplastic Polyps Without Improving Clinically Meaningful Neoplasia Endpoints

Zhenkang Li, Junpeng Huang, Lang Xie

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Acetylation-induced degradation of ECHS1 enhances BCAA accumulation and proliferation in KRAS-mutant colorectal cancer

Zhenkang Li, Zhengyu Liu, Mingdao Lin, Huayang Pan et autres

BACKGROUND: Branched-chain amino acid (BCAA) metabolism is dysregulated in colorectal cancer (CRC), with elevated plasma BCAA levels significantly associated with an increased risk of developing the disease. However, whether BCAAs directly promote CRC progression and their underlying mechanisms remain unclear. METHODS: In …

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Targeting MS4A4A on tumour-associated macrophages restores CD8+ T-cell-mediated antitumour immunity

Yongsheng Li, Zhiyong Shen, Zhen Chai, Yizhi Zhan et autres

Objective Checkpoint immunotherapy unleashes T-cell control of tumours but is suppressed by immunosuppressive myeloid cells. The transmembrane protein MS4A4A is selectively highly expressed in tumour-associated macrophages (TAMs). Here, we aimed to reveal the role of MS4A4A + TAMs in regulating the immune …

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S100P contributes to promoter demethylation and transcriptional activation of SLC2A5 to promote metastasis in colorectal cancer

Mingdao Lin, Yuan Fang, Zhenkang Li, Yongsheng Li et autres

BACKGROUND: SLC2A5 is a high-affinity fructose transporter, which is frequently upregulated in multiple human malignant tumours. However, the function and molecular mechanism of SLC2A5 in colorectal cancer (CRC) remain unknown. METHODS: We detected the expression levels of SLC2A5 in CRC tissues and …

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SNX16 activates c‐Myc signaling by inhibiting ubiquitin‐mediated proteasomal degradation of eEF1A2 in colorectal cancer development

Zhiyong Shen, Yongsheng Li, Yuan Fang, Mingdao Lin et autres

Sorting nexin 16 (SNX16), a member of the sorting nexin family, has been implicated in tumor development. However, the function of SNX16 has not yet been investigated in colorectal cancer (CRC). Here, we showed that SNX16 expression was significantly upregulated in CRC …

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POTEE drives colorectal cancer development via regulating SPHK1/p65 signaling

Zhiyong Shen, Xiaochuang Feng, Yuan Fang, Yongsheng Li et autres

Aberrant gene expression plays critical roles in the development of colorectal cancer (CRC). Here we show that POTEE, which was identified as a member E of POTE ankyrin domain family, was significantly upregulated in colorectal tumors and predicted poor overall survival of …

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