Chris A. Benedict

IL-27 induces a cytotoxic state in CD4 + T cells distinct from the Th1 lineage

Maria Inês Matias, Rémi Marrocco, Kyle Magro, Leonardo D. Sanchez Solis et autres

Abstract CD4 + cytotoxic T lymphocytes (CD4-CTLs) are understudied immune mediators with ambiguous origins. Despite expressing RUNX3, granzyme B (GZMB), and perforin (PRF1), CD4-CTLs are frequently classified as Th1 extensions due to shared interferon-γ (IFNγ) and T-BET expression. Here, we identify interleukin-27 …

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Data for EMSL Project 61552 from April 2026

Jason Toyoda, Sarah Leichty, Kaizad Patel, John Bargar et autres

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Redirecting cytomegalovirus immunity against pancreas cancer for immunotherapy

Rémi Marrocco, Jay Patel, Rithika Medari, Philip Salu et autres

BACKGROUND: Immunotherapy has had limited success in pancreatic cancer, largely due to a low mutational burden and immunosuppressive microenvironment. Here we hypothesized that systemic delivery of viral antigens can redirect pre-existing antiviral immunity against pancreatic tumors. METHODS: Cytomegalovirus (CMV, a β-herpesvirus) was …

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Optimization of Off-Season Cardiovascular Endurance through Integrative Recovery Modalities among Philippine Collegiate Swimmers

By Asst, Chris A. Benedict, Estarija

Sex biases in ILC1 phenotypes do not alter immune control of cytomegalovirus

Rémi Marrocco, Meghan U. Nguyen, Andrea Balcan, Kaia Robinson et autres

Re-directing anti-CMV memory immunity against pancreatic tumors for immunotherapy 2486

Rémi Marrocco, Jay Patel, Rithika Medari, Philip Salu et autres

Abstract Description Current immunotherapies rely on tumor-associated neoantigen, and the presence of T cells specific for those neoantigen. As such, solid malignancies like pancreatic cancer having low mutational burden and very immunosuppressive microenvironment do not respond to immunotherapy. An alternative approach is …

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Opposing role of type-I IFN for cNK and ILC1 during homeostasis and infection 2491

Rémi Marrocco, Eduardo Lucero Meza, Chris A. Benedict

Abstract Description Type-I innate lymphoid cells (ILC1) and conventional natural killer (cNK) cells belong to the group-I ILCs (gILC1), characterized largely by T-bet expression, IFNγ secretion, and cytotoxic activity. While much has been done to define factors that regulate the development, differentiation …

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Hyperinsulinemia promotes atherosclerosis by inducing metabolic reprogramming of autoreactive CD4+ T cells 2359

Felix Sebastian Nettersheim, Marco Orecchioni, Payel Roy, Monica Billitti et autres

Abstract Description Apolipoprotein B (ApoB)-specific CD4+ T cells predominantly exhibit Treg-like signatures in healthy mice and humans but some acquire proinflammatory phenotypes that contribute to atherosclerosis progression. The mechanisms driving this phenotype switching are largely unknown. We demonstrate that exposure to a …

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Co-inhibition of PD-1 and CD73 breaks tolerance of autoreactive CD4+ T cells in vivo 2362

Felix Sebastian Nettersheim, Simon Brunel, Robert S. Sinkovits, Sujit Silas Armstrong Suthahar et autres

Abstract Description How the immune system distinguishes self from foreign antigens is incompletely understood. Particularly, it is not known why vaccination with self and foreign peptides induces weak and strong expansion of antigen-specific CD4+ T cells, respectively. By utilizing computational analysis of …

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The GATE glycoprotein complex enhances human cytomegalovirus entry in endothelial cells

Michael J. Norris, Lauren A. Henderson, Mohammed Nure Alam Siddiquey, Jieyun Yin et autres

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Redirecting cytomegalovirus immunity against pancreas cancer for immunotherapy

Rémi Marrocco, Jignesh K. Patel, Rithika Medari, Philip Salu et autres

Abstract Immunotherapy shows limited success in pancreatic cancer, largely due to a low mutational burden and immunosuppressive microenvironment. Here we hypothesized that pre-existing antiviral immunity can be redirected to control pancreatic tumors. Cytomegalovirus (CMV, a β-herpesvirus) was chosen, as the majority of …

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Type I interferon regulation of group I ILC subsets during both homeostasis and cytomegalovirus infection

Rémi Marrocco, Eduardo Lucero-Meza, Chris A. Benedict

Type 1 innate lymphoid cells (ILC1s) and conventional natural killer cells belong to the group 1 ILCs (gILC1), characterized largely by T-bet expression and interferon γ secretion. While much has been done to define factors that regulate the development, differentiation, and effector …

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