Jean-François Simon

Exploring QRICH2 as a potential male contraceptive target

Amandine Delnatte, Messaline Inglese, Jérôme Delroisse, Denis Nonclercq et autres

Today, male contraceptive options remain limited to condoms and vasectomy, highlighting the urgent need for alternative methods. In this context, discovering and characterizing reproductive-tract-specific proteins that can be targeted by natural or chemical molecules is of particular interest. Recent studies on the …

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Novel insights into human CRISP2: localization in reproductive tissues and sperm, and molecular characterization

Thibault Masai, Amandine Delnatte, Marie Dendievel, Denis Nonclercq et autres

CRISP2 is enriched in the male reproductive system of mammals and plays roles in spermatogenesis, sperm motility, and fertilization. Although extensively investigated in rodents and boars, human CRISP2 (hCRISP2) remains poorly studied, particularly concerning its localization in testicular and epididymal tissues and …

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Dans le regard de l’Autre

Jean-François Simon

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Mise à jour de la caractérisation de la protéine spermatique humaine CRISP2 : analyse de sa localisation, de ses modifications post-traductionnelles et de son oligomérisation

Thibault Masai, Marie Dendievel, Jean-François Simon, Vanessa Arcolia et autres

peer reviewed

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Influence of Two Widely Used Solvents, Ethanol and Dimethyl Sulfoxide, on Human Sperm Parameters

Marie Bisconti, Philippe Grosjean, Vanessa Arcolia, Jean-François Simon et autres

To study mechanisms involved in fertility, many experimental assays are conducted by incubating spermatozoa in the presence of molecules dissolved in solvents such as ethanol (EtOH) or dimethyl sulfoxide (DMSO). Although a vehicle control group is usually included in such studies, it …

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Influence de l’éthanol et du DMSO, deux solvants couramment utilisés dans l’étude de la fertilité, sur les paramètres des spermatozoïdes humains

Marie Bisconti, Jean-François Simon, Vanessa Arcolia, Elise Hennebert

peer reviewed

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Influence of ethanol and dimethyl sulfoxide, two solvents commonly used in fertility studies, on human sperm parameters

Marie Bisconti, Jean-François Simon, Vanessa Arcolia, Elise Hennebert

editorial reviewed

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Characterization of CRISP2 in human spermatozoa

Thibault Masai, Marie Dendievel, Jean-François Simon, Vanessa Arcolia et autres

editorial reviewed

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The ribosome inhibitor chloramphenicol induces motility deficits in human spermatozoa: A proteomic approach identifies potentially involved proteins

Marie Bisconti, Baptiste Leroy, Meurig T. Gallagher, Coralie Senet et autres

capacitation. But the type of ribosomes involved (cytoplasmic or mitochondrial) is still debated. Here, we investigate the presence and activity of the two types of ribosomes in mature human spermatozoa. By targeting ribosomal RNAs and proteins, we show that both types of …

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The ribosome inhibitor chloramphenicol induces motility deficits in human spermatozoa: a proteomic approach identifies potentially involved proteins

Marie Bisconti, Baptiste Leroy, Meurig T. Gallagher, Coralie Senet et autres

Abstract Mature spermatozoa are almost completely devoid of cytoplasm; as such it has long been believed that they do not contain ribosomes and are therefore not capable of synthesising proteins. However, since the 1950s, various studies have shown translational activity within spermatozoa, …

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Targeted Analysis of HSP70 Isoforms in Human Spermatozoa in the Context of Capacitation and Motility

Sarah Grassi, Marie Bisconti, Baptiste Martinet, Vanessa Arcolia et autres

HSP70s constitute a family of chaperones, some isoforms of which appear to play a role in sperm function. Notably, global proteomic studies analyzing proteins deregulated in asthenozoospermia, a main cause of male infertility characterized by low sperm motility, showed the dysregulation of …

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Influence des facteurs de risque d'infertilité masculine sur le protéome des spermatozoïdes

Marie Bisconti, Elise Hennebert, Vanessa Arcolia, Jean-François Simon

peer reviewed

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