Denis Nonclercq

P234 - ECE_3795 - Impact of in utero exposure to sesamol on folliculogenesis

Manon Fiévet, Gabrielle Sulimowski, Louisa Menu, Annica Frau et autres

Abstract The growing popularity of vegetarian and vegan diets has significantly increased our exposure to phytoestrogens, which are potential endocrine disruptors. Sesamol, obtained by roasting sesame seeds, is classified as a phytoestrogen. As hormonal variations play a decisive role in the formation …

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Exploring QRICH2 as a potential male contraceptive target

Amandine Delnatte, Messaline Inglese, Jérôme Delroisse, Denis Nonclercq et autres

Today, male contraceptive options remain limited to condoms and vasectomy, highlighting the urgent need for alternative methods. In this context, discovering and characterizing reproductive-tract-specific proteins that can be targeted by natural or chemical molecules is of particular interest. Recent studies on the …

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Toward the development of an innovative pharmacological compound employing peptides for EGFR-mediated drug delivery in anaplastic thyroid carcinoma

Zehra-Cagla Kahvecioglu, M. Bougard, Olivia Rasson, Amandine Nachtergael et autres

Anaplastic thyroid cancer (ATC) represents the deadliest thyroid tumor in humans. Current treatments have not really demonstrated a long-term benefit. Accordingly, targeted drug delivery should be considered to improve the prognosis of patients, but also the early-stage diagnosis. Epidermal Growth Factor Receptor …

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Impact de l'exposition in utero au sésamol sur la folliculogenèse et le métabolisme de la descendance F1 chez le rat

Manon Fiévet, Louisa Menu, Margaux Moreau, Lucie Roman et autres

editorial reviewed

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Impact of in utero exposure to sesamol on the folliculogenesis and metabolism in F1 female offspring rats

Manon Fiévet, Louisa Menu, Annica Frau, Denis Nonclercq

Impact de l'exposition in utero au sésamol sur le système reproducteur chez le rat

Manon Fiévet, Louisa Menu, Margaux Moreau, Annica Frau et autres

editorial reviewed

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Novel insights into human CRISP2: localization in reproductive tissues and sperm, and molecular characterization

Thibault Masai, Amandine Delnatte, Marie Dendievel, Denis Nonclercq et autres

CRISP2 is enriched in the male reproductive system of mammals and plays roles in spermatogenesis, sperm motility, and fertilization. Although extensively investigated in rodents and boars, human CRISP2 (hCRISP2) remains poorly studied, particularly concerning its localization in testicular and epididymal tissues and …

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PIP3 and EGFR dual targeting for the development of a polypeptide complex drug aimed at the specific delivery and therapy of anaplastic thyroid carcinoma

Zehra-Cagla Kahvegioglu, Alison Daubry, Ami Gloria Toulehohoun, Charlotte Rogien et autres

Etude comparative de la morphologie de l'oeil chez quatre espèces de lézards tropicaux (Scincidae) occupant différentes niches écologiques

Sébastien Gennaux, George Dolinskii, Sébastien Boutry, Denis Nonclercq

editorial reviewed

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Impact de l'exposition prénatale au sésamol sur le développement du système reproducteur chez le rat

Manon Fiévet, Louisa Menu, Margaux Moreau, Annica Frau et autres

editorial reviewed

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Modulation of Cytosolic Phospholipase A2 as a Potential Therapeutic Strategy for Alzheimer’s Disease

Séverine André, Sébastien Verteneuil, Laurence Ris, Zehra-Cagla Kahvecioglu et autres

Background: Alzheimer’s disease (AD) is a neurodegenerative disorder lacking any curative treatment up to now. Indeed, actual medication given to the patients alleviates only symptoms. The cytosolic phospholipase A2 (cPLA 2 -IVA) appears as a pivotal player situated at the center of …

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The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins

Clothilde Claus, Moriya Slavin, Eugénie Ansseau, Céline Lancelot et autres

BACKGROUND: We have previously demonstrated that double homeobox 4 centromeric (DUX4C) encoded for a functional DUX4c protein upregulated in dystrophic skeletal muscles. Based on gain- and loss-of-function studies we have proposed DUX4c involvement in muscle regeneration. Here, we provide further evidence for …

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