Nancy L. Buechler

Development of DNase‐1 Loaded Polymeric Nanoparticles Synthesized by Inverse Flash Nanoprecipitation for Neutrophil‐Mediated Drug Delivery to In Vitro Thrombi

Sophie L. Maiocchi, Erica E. Burnham, Ana Cartaya, Veronica Lisi et autres

Activated neutrophils release Neutrophil Extracellular Traps (NETs), comprising decondensed chromatin, peroxidases, and serine proteases, which aid in host defense but are also implicated in thrombosis and resistance to thrombolysis. Recombinant DNase 1, which degrades NETs, may aid in thrombus dissolution synergistically with …

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Optimizing Nanoparticle Size and Dose for Enhanced Cell-Mediated Drug Delivery: Impact on Neutrophil Mitochondrial Function and Chemotaxis.

Veronica Lisi, Erika Burham, Rachel E. Pollard, Nancy L. Buechler et autres

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Effect of nanoparticle internalization on migration & adhesion activity in human neutrophils: focus on the mitochondria

Veronica Lisi, Nancy L. Buechler, Erica E. Burnham, Nathalie M. Pinkerton et autres

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Author Response: Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

Rabina Mainali, Nancy L. Buechler, Cristian Ortero, Laken Edwards et autres

One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate.Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however, its effects in other organ …

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Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

Rabina Mainali, Nancy L. Buechler, Cristian Otero, Laken Edwards et autres

One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however, its effects in other …

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Reviewer #1 (Public Review): Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

Rabina Mainali, Nancy L. Buechler, Cristian Otero, Laken Edwards et autres

One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however, its effects in other …

Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

Rabina Mainali, Nancy L. Buechler, Cristian Otero, Laken Edwards et autres

One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however, its effects in other …

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Reviewer #2 (Public Review): Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

Rabina Mainali, Nancy L. Buechler, Cristian Otero, Laken Edwards et autres

One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however, its effects in other …

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Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

Rabina Mainali, Nancy L. Buechler, Cristian Otero, Laken Edwards et autres

Abstract One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however, its effects in …

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Author Response: Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

Rabina Mainali, Nancy L. Buechler, Cristian Otero, Laken Edwards et autres

One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however, its effects in other …

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Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

Rabina Mainali, Nancy L. Buechler, Cristian Otero, Laken Edwards et autres

Abstract One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however, its effects in …

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Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

Rabina Mainali, Manal Zabalawi, David L. Long, Nancy L. Buechler et autres

Metabolic reprogramming between resistance and tolerance occurs within the immune system in response to sepsis. While metabolic tissues such as the liver are subjected to damage during sepsis, how their metabolic and energy reprogramming ensures survival is unclear. Employing comprehensive metabolomic, lipidomic, …

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