Nathalie M. Pinkerton

Engineering Nanoscale Drug Delivery Systems for Pain

Rachel E. Pollard, Amy S. Moreno, Vic M. Hempstead, Alan D. Hegron et autres

Pain is a pervasive and multifaceted condition that imposes a significant medical and economic burden worldwide. This burden is underscored by the urgent need for transformative, non-addictive opioid alternatives. Nanomedicine offers a promising avenue for addressing the many limitations associated with conventional …

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Spatiotemporal Immune Modulation Using Light‐Responsive Nanoparticles With Confinement‐Enhanced Photocleavage

Amy S. Moreno, Rachel E. Pollard, Vic M. Hempstead, Jennifer Vilnot et autres

ABSTRACT Spatiotemporal control over immune agonist delivery remains a critical unmet need in immuno‐oncology, where systemic administration risks off‐target immune activation. Here, we present a self‐reporting, light‐responsive polymeric nanoparticle (NP) system for triggered drug release via one‐photon (1P) UV or two‐photon (2P) …

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Spatiotemporal Immune Modulation Using Light-Responsive Nanoparticles with Confinement-Enhanced Photocleavage

Nathalie M. Pinkerton

All data for the publication entitled "Spatiotemporal Immune Modulation Using Light-Responsive Nanoparticles with Confinement-Enhanced Photocleavage"

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Spatiotemporal Immune Modulation Using Light-Responsive Nanoparticles with Confinement-Enhanced Photocleavage

Nathalie M. Pinkerton

All data for the publication entitled "Spatiotemporal Immune Modulation Using Light-Responsive Nanoparticles with Confinement-Enhanced Photocleavage"

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Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia

Shavonne L. Teng, Rocco Latorre, Divya Bhansali, Parker K. Lewis et autres

Although many internalized G protein-coupled receptors (GPCRs) continue to signal, the mechanisms and outcomes of intracellular GPCR signaling are uncertain due to the challenges of measuring organelle-specific signals and of selectively antagonizing receptors in intracellular compartments. Herein, genetically encoded biosensors targeted to …

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20 years of Flash NanoPrecipitation – from controlled precipitation to global medicine

Kurt D. Ristroph, Nathalie M. Pinkerton, Chester E. Markwalter, Suzanne M. D’Addio et autres

In the twenty years since the development of Flash NanoPrecipitation (FNP) technology, an antisolvent precipitation technique that uses rapid turbulent mixing to drive self-assembly of polymeric or lipid nanoparticles, the platform has been used for a wide variety of drug delivery applications …

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Nanoparticle-mediated antagonism of sustained endosomal signaling of the calcitonin receptor-like receptor provides enhanced and persistent relief of oral cancer pain

Chloe J. Peach, Nguyen Huu Tu, Parker K. Lewis, Rachel E. Pollard et autres

By improving the delivery and tumor retention of chemotherapeutics, nanomedicines hold potential for cancer treatment. The usefulness of nanoparticle (NP)-encapsulated analgesics for the cancer pain treatment is comparatively unexplored. We investigated whether NPs encapsulating olcegepant (OCP), an antagonist of the calcitonin receptor-like …

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A Comparative Study of Flash Nanoprecipitation and Sequential Nanoprecipitation: Impact of Formulation Parameters on Drug-Loaded Nanoparticle Formation

Nouha El Amri, Amy H. McKinstry, Rachel E. Pollard, Parker K. Lewis et autres

Flash NanoPrecipitation (FNP) is a well-established method for forming core-shell drug-loaded nanoparticles that has demonstrated effectiveness for encapsulating highly hydrophobic compounds. However, certain formulation challenges persist, including size limitations and reduced encapsulation efficiency for moderately hydrophobic drugs. Sequential NanoPrecipitation (SNaP) is a …

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Process and Formulation Parameters Governing Polymeric Microparticle Formation via Sequential NanoPrecipitation (SNaP)

Parker K. Lewis, Nouha El Amri, Erica E. Burnham, Natalia Arrus et autres

High Resolution Image Download MS PowerPoint Slide Polymeric microparticles (MPs) are valuable drug delivery vehicles for extended-release applications, but current manufacturing techniques present significant challenges in balancing size control with scalability. Industrial synthesis processes provide high throughput but limited precision, while laboratory-scale …

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Development of DNase‐1 Loaded Polymeric Nanoparticles Synthesized by Inverse Flash Nanoprecipitation for Neutrophil‐Mediated Drug Delivery to In Vitro Thrombi

Sophie L. Maiocchi, Erica E. Burnham, Ana Cartaya, Veronica Lisi et autres

Activated neutrophils release Neutrophil Extracellular Traps (NETs), comprising decondensed chromatin, peroxidases, and serine proteases, which aid in host defense but are also implicated in thrombosis and resistance to thrombolysis. Recombinant DNase 1, which degrades NETs, may aid in thrombus dissolution synergistically with …

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Sequential nanoprecipitation for theranostics: Resolving assembly timescale mismatch in composite nanoparticle synthesis

Rachel E. Pollard, Nouha El Amri, Parker K. Lewis, Jacques Zacharie Thaddeus P. Ponce et autres

Abstract Biomedical applications of colloidal nanocrystals (NC) have focused on nanoscale theranostics, that is, composite nanoparticles (CNP) that function as bioimaging probes while simultaneously delivering therapeutic payloads. Thus, there is a need for controlled CNP manufacturing methods that sufficiently decouple vehicle and …

Design of Modular, 3D‐Printed Millifluidic Mixers to Enable Sequential NanoPrecipitation (SNaP) for the Tunable Synthesis of Drug‐Loaded Nanoparticles and Microparticles (Adv. Mater. Technol. 1/2025)

Thomas Y. Belinky, Nouha El Amri, Parker K. Lewis, Allie Karakosta LeMay et autres

Sequential NanoPrecipitation (SNaP) is a nascent controlled precipitation process for the tunable formation of polymeric particles for drug delivery and bioimaging. While SNaP relies on the same self-assembly principles as one-step Flash NanoPrecipitation, SNaP is a two-step assembly process in which the …

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