Intelly S Lee

SLC7A8 is essential for metabolic fitness and function of Th2 cells

Santosh K. Panda, Do-Hyun Kim, Pritesh Desai, Sang Ik Wu et autres

Amino acids are essential for the activation and function of CD4 T helper (Th) cells, which differentiate into Th1, Th2, Th17, and Treg subsets to coordinate immune responses. While specific amino acid transporters have been identified for Th1, Th17, and Tregs, a …

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Both Horatio and Polonius: Innate Lymphoid Cells in Tissue Homeostasis and Repair

Intelly S Lee, Steven J. Van Dyken

Innate lymphoid cells (ILCs) have emerged as critical tissue-resident lymphocytes that coordinate responses to environmental stress and injury. Traditionally, their function was thought to mirror adaptive lymphocytes that respond to specific pathogens. However, recent work has uncovered a more central role for …

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Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T Cells

Herbert G. Kasler, Intelly S Lee, Hyung W. Lim, Eric Verdin

We report that Histone Deacetylase 7 (HDAC7) controls the thymic effector programming of Natural Killer T (NKT) cells, and that interference with this function contributes to tissue-specific autoimmunity. Gain of HDAC7 function in thymocytes blocks both negative selection and NKT development, and …

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Author response: Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T Cells

Herbert G. Kasler, Intelly S Lee, Hyung W. Lim, Eric Verdin

The development of Natural Killer T Cells is controlled by Histone Deacetylase 7, a function that combined with its known role in thymic negative selection provides a potential mechanism explaining its association with tissue-specific autoimmunity in humans.

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Histone Deacetylase 7 Mediates Tissue-Specific Autoimmunity via Control of Innate Effector Function in Invariant Natural Killer T-Cells

Herbert G. Kasler, Intelly S Lee, Hyung W. Lim, Eric Verdin

Abstract We report that Histone Deacetylase 7 (HDAC7) controls the thymic effector programming of Natural Killer T (NKT) cells, and that interference with this function contributes to tissue-specific autoimmunity. Gain of HDAC7 function in thymocytes blocks both negative selection and NKT development, …

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Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

Kotaro Shirakawa, Lan Wang, Na Man, Jasna Maksimoska et autres

Salicylate and acetylsalicylic acid are potent and widely used anti-inflammatory drugs. They are thought to exert their therapeutic effects through multiple mechanisms, including the inhibition of cyclo-oxygenases, modulation of NF-κB activity, and direct activation of AMPK. However, the full spectrum of their …

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Author response: Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

Kotaro Shirakawa, Lan Wang, Na Man, Jasna Maksimoska et autres

People have been using a chemical called salicylate, which was once extracted from willow tree bark, as medicine for pain, fever and inflammation since ancient Greece. Aspirin is derived from salicylate but is a more potent drug. Aspirin exerts its anti-inflammatory effect …

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SIRT1 deacetylates RORγt and enhances Th17 cell generation

Hyung W. Lim, Seung Goo Kang, Jae Kyu Ryu, Birgit Schilling et autres

Author(s): Lim, Hyung W; Kang, Seung Goo; Ryu, Jae Kyu; Schilling, Birgit; Fei, Mingjian; Lee, Intelly S; Kehasse, Amanuel; Shirakawa, Kotaro; Yokoyama, Masaru; Schnölzer, Martina; Kasler, Herbert G; Kwon, Hye-Sook; Gibson, Bradford W; Sato, Hironori; Akassoglou, Katerina; Xiao, Changchun; Littman, Dan R; …

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SIRT1 deacetylates RORγt and enhances Th17 cell generation

Hyung W. Lim, Seung Goo Kang, Jae Kyu Ryu, Birgit Schilling et autres

The balance of effector and regulatory T cell function, dependent on multiple signals and epigenetic regulators, is critical to immune self-tolerance. Dysregulation of T helper 17 (Th17) effector cells is associated with multiple autoimmune diseases, including multiple sclerosis. Here, we report that …

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Nuclear export of histone deacetylase 7 during thymic selection is required for immune self‐tolerance

Herbert G. Kasler, Hyung W. Lim, Denis Mottet, Amy Collins et autres

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