Herbert G. Kasler

Ketone ester supplementation reduces age-associated B cell activation in aged mice without impairing antibody responses

Ariel Adkisson‐Floro, Ritesh Tiwari, Mitsunori Nomura, Rebeccah Riley et autres

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Ketone ester supplementation reduces age-associated B cell activation in aged mice without impairing antibody responses

Ariel Adkisson‐Floro, Ritesh Tiwari, Mitsunori Nomura, Rebeccah Riley et autres

Abstract Background Aging in the immune system results in increased susceptibility to infections, exacerbated autoimmunity, and reduced responsiveness to vaccines. However, there are no current established interventions for immune aging. Ketogenic diets and fasting have been researched as interventions against other aspects …

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Murine Progeria Model Exhibits Delayed Fracture Healing With Senescent Phenotype and Dysregulated Immune Response

Victoria R. Duke, Marc J. Philippon, Dane R.G. Lind, Herbert G. Kasler et autres

ABSTRACT An estimated 189 million bone fractures occurred in 2019 making it one of the most globally prevalent injuries. Delayed union or nonunion occurs in up to 15% of normal fractures with higher rates in aged individuals. Preclinical testing supports the translation …

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Author Correction: Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial

Dominic Denk, Anurag Singh, Herbert G. Kasler, Davide D’Amico et autres

In the version of the article initially published, Fig. 3e was inadvertently a duplicate of Fig. 3b. Fig. 3 has now been amended with the correct panel e in the HTML and PDF versions of the article.

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Multi-omics Analysis of Human Blood Cells Reveals Unique Features of Age-associated Type2 CD8 Memory T cells

Hiroyuki Matsui, Marlene Cervantes, Mir M. Khalid, Alan Tomusiak et autres

Aging impacts immune function, but the mechanisms driving age-related changes in immune cell subsets remain unclear. To explore age-dependent changes in immune cell populations, we analyzed human peripheral blood mononuclear cells (PBMCs) from a cohort of healthy donors aged 20-82 years using …

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Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial

Dominic Denk, Anurag Singh, Herbert G. Kasler, Davide D’Amico et autres

Mitochondrial dysfunction and stem cell exhaustion contribute to age-related immune decline, yet clinical interventions targeting immune aging are lacking. Recently, we demonstrated that urolithin A (UA), a mitophagy inducer, expands T memory stem cells (TSCM) and naive T cells in mice. In …

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Additional Cover

Matías Fuentealba, D Kiprov, Kevin Schneider, Wei‐Chieh Mu et autres

Cover legend: The cover image is based on the article Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange by Matias Fuentealba et al., https://doi.org/10.1111/acel.70103.

Accumulation of SA-βGal–High Cells in Human Naïve T Cell Compartments Reveals a Stress-Adapted, Senescent-Like State

Andreea Cristina Alexandru, Genesis Vega Hormazabal, Hiroyuki Matsui, Herbert G. Kasler et autres

ABSTRACT Aging is associated with a decline in immune function termed immunosenescence, characterized by accumulation of senescent-like immune cells and chronic inflammation, known as inflammaging. While senescence-associated β-galactosidase (SA-βGal) activity is a well-established senescence marker, its functional significance and the precise cellular …

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Multi‐Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single‐Blinded Randomized Placebo‐Controlled Therapeutic Plasma Exchange

Matías Fuentealba, D Kiprov, Kevin Schneider, Wei‐Chieh Mu et autres

We conducted a randomized, placebo-controlled trial to assess the safety and biological age (BA) effects of various therapeutic plasma exchange (TPE) regimens in healthy adults over 50. Participants received bi-weekly TPE with or without intravenous immunoglobulin (IVIG), monthly TPE, or placebo. Randomization …

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Multi-omics Analysis Reveals Biomarkers that Contribute to Biological Age Rejuvenation in Response to Therapeutic Plasma Exchange

Matías Fuentealba, D Kiprov, Kevin Schneider, Wei‐Chieh Mu et autres

Abstract The rapid increase in the proportion of older adults worldwide poses a huge challenge for healthcare systems. Currently, age-related chronic diseases account for over 90% of annual healthcare expenditures (more than $4.1 trillion) in the US alone. Thus, new therapies to …

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Development of an epigenetic clock resistant to changes in immune cell composition

Alan Tomusiak, Ariel Floro, Ritesh Tiwari, Rebeccah Riley et autres

Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG methylation values to predict chronological or biological age. Increases in predicted epigenetic age relative to chronological age (epigenetic age acceleration) are connected to aging-associated pathologies, and changes in epigenetic …

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Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight

Fei Wu, Huixun Du, Eliah Overbey, JangKeun Kim et autres

Microgravity is associated with immunological dysfunction, though the mechanisms are poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear cells (PBMCs) exposed to short term (25 hours) simulated microgravity, we characterize altered genes and pathways at basal and stimulated states …

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