Fanny Ng

TRAP-seq Profiling and RNAi-Based Genetic Screens Identify Conserved Glial Genes Required for Adult Drosophila Behavior

Fanny Ng, Sukanya Sengupta, Yanmei Huang, Aimin Yu et autres

Although, glial cells have well characterized functions in the developing and mature brain, it is only in the past decade that roles for these cells in behavior and plasticity have been delineated. Glial astrocytes and glia-neuron signaling, for example, are now known …

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The ROP vesicle release factor is required in adult Drosophila glia for normal circadian behavior

Fanny Ng, F. Rob Jackson

We previously showed that endocytosis and/or vesicle recycling mechanisms are essential in adult Drosophila glial cells for the neuronal control of circadian locomotor activity. In this study, our goal was to identify specific glial vesicle trafficking, recycling, or release factors that are …

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Comparison of Larval and Adult Drosophila Astrocytes Reveals Stage-Specific Gene Expression Profiles

Yanmei Huang, Fanny Ng, F. Rob Jackson

The analysis of adult astrocyte glial cells has revealed a remarkable heterogeneity with regard to morphology, molecular signature, and physiology. A key question in glial biology is how such heterogeneity arises during brain development. One approach to this question is to identify …

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Glial Cell Regulation of Rhythmic Behavior

F. Rob Jackson, Fanny Ng, Sukanya Sengupta, Samantha You et autres

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Phosphorylation of a Central Clock Transcription Factor Is Required for Thermal but Not Photic Entrainment

Euna Lee, Eun Hee Jeong, Hyun‐Jeong Jeong, Evrim Yildirim et autres

Transcriptional/translational feedback loops drive daily cycles of expression in clock genes and clock-controlled genes, which ultimately underlie many of the overt circadian rhythms manifested by organisms. Moreover, phosphorylation of clock proteins plays crucial roles in the temporal regulation of clock protein activity, …

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Phosphorylation of the Transcription Activator CLOCK Regulates Progression through a ∼24-h Feedback Loop to Influence the Circadian Period in Drosophila

Guruswamy Mahesh, Eun-Hee Jeong, Fanny Ng, Yixiao Liu et autres

Circadian (≅ 24 h) clocks control daily rhythms in metabolism, physiology, and behavior in animals, plants, and microbes. In Drosophila, these clocks keep circadian time via transcriptional feedback loops in which clock-cycle (CLK-CYC) initiates transcription of period (per) and timeless (tim), accumulating …

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Activating Membership through Mentorship: A Collaborative Dialogue to Enhance Division Membership

Anjuli Amin, Edward R. Hines, Ivy K. Ho, Fanny Ng et autres

Multiple Meanings of Race and Ethnicity

Shruti Mukkamala, Fanny Ng, Micaela D. Curley, Karen L. Suyemoto

Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin in Drosophila melanogaster

Audrey Chen, Fanny Ng, Tim Lebestky, Anna Grygoruk et autres

To investigate the regulation of Drosophila melanogaster behavior by biogenic amines, we have exploited the broad requirement of the vesicular monoamine transporter (VMAT) for the vesicular storage and exocytotic release of all monoamine neurotransmitters. We used the Drosophila VMAT (dVMAT) null mutant …

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Physiologic and psychosocial approaches to global management of the hemodialysis patient in the Southern Alberta Renal Program.

Tina Cormier, Ofelia Magat, Suzy Hager, Fanny Ng et autres

As frontline nurses, we know firsthand the many challenges of renal disease faced by our patients and the impact on their lives and their families. How can we help them cope with their illness? How can we improve their quality of life? …

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Cellular Requirements for LARK in the Drosophila Circadian System

Vasudha Sundram, Fanny Ng, Mary Ann Roberts, Carola Millán et autres

RNA-binding proteins mediate posttranscriptional functions in the circadian systems of multiple species. A conserved RNA recognition motif (RRM) protein encoded by the lark gene is postulated to serve circadian output and molecular oscillator functions in Drosophila and mammals, respectively. In no species, …

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The C-terminal Kinase and ERK-binding Domains of Drosophila S6KII (RSK) Are Required for Phosphorylation of the Protein and Modulation of Circadian Behavior

Michelle M. Tangredi, Fanny Ng, F. Rob Jackson

A detailed structure/function analysis of Drosophila p90 ribosomal S6 kinase (S6KII) or its mammalian homolog RSK has not been performed in the context of neuronal plasticity or behavior. We previously reported that S6KII is required for normal circadian periodicity. Here we report …

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