David F. Tang‐Wai

Cerebral Microbleeds and Superficial Siderosis: Vascular Correlates and Cognition in a Memory Clinic

Hessah Ateeq Alotibi, Juan‐Camilo Vargas‐González, Paula Alcaide-Leon, David F. Tang‐Wai et autres

OBJECTIVE: Cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS) are increasingly recognized in patients with cognitive impairment and are considered markers of cerebral small vessel disease and cerebral amyloid angiopathy (CAA). However, their associated variable and cognitive impact remain under-characterized in memory …

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Cellular signatures underlying functional resilience in presymptomatic frontotemporal dementia

Kamen A. Tsvetanov, Maura Malpetti, P. Simon Jones, Timothy Rittman et autres

Frontotemporal dementia (FTD) shows autosomal dominant transmission in up to a third of families, enabling the study of presymptomatic and prodromal phases. Despite self-reported well-being and normal daily cognitive functioning, brain structural changes are evident a decade or more before the expected …

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Cerebrovascular Reactivity at Rest and Its Association With Cognitive Function in People With Genetic Frontotemporal Dementia

Ivana Kancheva, Arabella Bouzigues, Lucy L. Russell, Phoebe H. Foster et autres

BACKGROUND AND OBJECTIVES: Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular health, and its signature in familial frontotemporal dementia (FTD) remains unknown. The primary aim was to investigate CVR in genetic FTD using an fMRI index of vascular contractility termed resting-state fluctuation …

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Delineating the Effects of Alcohol Use on Cognition in Individuals With Neurocognitive Disorders

Ari B. Cuperfain, Sandra E. Black, Mira Fostoc, Morris Freedman et autres

Excessive alcohol use is a recognized modifiable risk factor for the development of dementia; however, the neuropsychological profile of cognitive impairment seen with alcohol use is heterogeneous. We studied cognitive characteristics associated with alcohol use in a "real-world" memory clinic cohort of …

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Measuring long-term psychiatric outcomes in post-acute autoimmune encephalitis

Julien Hébert, Ramy Gabarin, Sydney Lee, Dilip Koshy et autres

PURPOSE: To compare the performance of different measures of long-term psychiatric outcomes in patients with post-acute autoimmune encephalitis (AE) who may require comprehensive psychiatric evaluation. METHODS: The sensitivity of three self-reported measures of mood and anxiety symptoms (Patient Health Questionnaire [PHQ-9]; Profiles …

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The utility of the Ascertain Dementia Eight-item Questionnaire (AD8) and Mini-Cog in detecting cognitive impairment in older surgical patients – The Detect CI study

Ellene Yan, Yasmin Alhamdah, Sinead Campbell, David He et autres

BACKGROUND: Brain health is often overlooked before surgery, missing an opportunity to identify at-risk patients. This study aimed to (1) examine the diagnostic performance of two ultra-rapid cognitive screening tools, the Ascertain Dementia Eight-item Questionnaire (AD8) and Mini-Cog, against a tool validated …

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Comprehensive intervention combining group and personalized language therapy in primary progressive aphasia: Quantitative and qualitative findings

Tijana Simić, Laura Laird, Rudra Patel, Monica Lavoie et autres

INTRODUCTION: Increasingly, studies are demonstrating language and communication improvement after behavioral interventions for primary progressive aphasia (PPA), and the caregiver perspective has been highlighted as critically important to determining treatment success in this population. This is an exploratory study investigating a comprehensive, …

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Distinct inflammatory profiles in young‐onset versus late‐onset Alzheimer's disease

Simrika Thapa, Chloe Anastassiadis, Anna Vasilevskaya, Foad Taghdiri et autres

INTRODUCTION: Neuroinflammation, a key player in Alzheimer's disease (AD) pathogenesis, may be differentially involved in young-onset (YOAD) compared to late-onset (LOAD) AD. METHODS: Using proximity extension assay technology, we examined 737 inflammatory markers in the CSF of 26 healthy controls (63.9 ± …

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A vision transformer approach for fully automated and scalable dementia screening using clock drawing test images

Michael B. Bone, Morris Freedman, Sandra E. Black, Daniel Felsky et autres

INTRODUCTION: The clock drawing test (CDT) screens for dementia but requires trained scorers and lacks standardized criteria. Thus, we developed an automated vision transformer (ViT)-based diagnostic system with convolutional neural network preprocessing for analyzing hand-drawn CDT images. METHODS: = 862; 522 dementia, …

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The Relationship between Age and Cognitive Subtypes of Alzheimer Syndrome and Related Dementias

Bruna Seixas Lima, Malcolm A. Binns, Sandra E. Black, Morris Freedman et autres

INTRODUCTION: We aimed to identify cognitive subgroups of clinically diagnosed Alzheimer's disease (Alzheimer syndrome) and related dementias and test if age of presentation influences patterns of cognitive impairment. METHODS: Participants were individuals with mild cognitive impairment (n = 360), vascular mild cognitive …

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Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration

Vishaal Sumra, Mohsen Hadian, Allison A. Dilliott, Sali M.K. Farhan et autres

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The Impact of Neuropsychiatric Symptoms in Perceived Quality of Life in Patients With Progressive Supranuclear Palsy

Alonso Morales‐Rivero, Indira García‐Cordero, Abeer Khoja, Juan‐Camilo Vargas‐González et autres

BACKGROUND AND OBJECTIVES: Progressive supranuclear paralysis (PSP) is an atypical parkinsonian disorder associated with oculomotor features, motor disturbances, along with cognitive problems and neuropsychiatric symptoms. Quality of life (QoL) is often assessed in relation to the motor symptoms. Our aim was to …

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