Abdelbaset A. Elzagallaai

Longitudinal assessment of changes in hair cortisol levels and associations with violence, poor mental health and harmful substance use among female sex workers in Nairobi, Kenya

Mamtuti Panneh, Tara Beattie, Qingming Ding, Rhoda Wanjiru Kabuti et autres

Female sex workers (FSWs) in sub-Saharan Africa commonly experience violence, mental health problems, and harmful substance use. Stressful life events can harm the functioning of the hypothalamic-pituitary-adrenal (HPA) axis, serving as a pathway to increased poor health, including HIV susceptibility through cortisol …

gb, ca, Kenya (code pays fourni par la source)

The pathophysiology of drug hypersensitivity

Michael John Rieder, Abdelbaset A. Elzagallaai

Drug Hypersensitivity reactions (DHRs) - either Immediate or Delayed – are among the most feared adverse effects of drug therapy. While DHRs are perhaps one-sixth of all ADRs, they are among the most problematic given that they are unpredictable, often severe and …

ca (code pays fourni par la source)

Associations of hair cortisol levels with violence, poor mental health, and harmful alcohol and other substance use among female sex workers in Nairobi, Kenya

Mamtuti Panneh, Qingming Ding, Rhoda Wanjiru Kabuti, John D. Bradley et autres

Violence, poor mental health, and harmful substance use are commonly experienced by female sex workers (FSWs) in sub-Saharan Africa, all of which are associated with increased HIV susceptibility. We aimed to investigate the associations between violence, poor mental health and harmful alcohol/substance …

gb, ca, Kenya (code pays fourni par la source)

Effects of species of origin and mode of induction of microsomes on carbamazepine-induced cell toxicity

Abdelbaset A. Elzagallaai, Awatif M. Abuzgaia, Michael J. Rieder

Standardization and validation of in vitro drug metabolism is essential for pre-clinical drug development as well as for in vitro toxicity assays including the lymphocyte toxicity assay (LTA) and the in vitro platelet toxicity assay (iPTA). Use of isolated liver microsomes (MIC) …

ca (code pays fourni par la source)

The role of environmental sensitivity in the mental health of Syrian refugee children: a multi-level analysis

Andrew K. May, Demelza M. Smeeth, Fiona S. McEwen, Elie Georges Karam et autres

Individuals with high environmental sensitivity have nervous systems that are disproportionately receptive to both the protective and imperilling aspects of the environment, suggesting their mental health is strongly context-dependent. However, there have been few consolidated attempts to examine putative markers of sensitivity, …

gb, lb, ca, it (code pays fourni par la source)

Hair hormone data from Syrian refugee children: Perspectives from a two-year longitudinal study

Andrew K. May, Demelza M. Smeeth, Fiona S. McEwen, Patricia Moghames et autres

For numerous issues of convenience and acceptability, hair hormone data have been increasingly incorporated in the field of war trauma and forced displacement, allowing retrospective examination of several biological metrics thought to covary with refugees’ mental health. As a relatively new research …

gb, lb, ca (code pays fourni par la source)

Not All Microsomes are Created Equal: Effects of Species of Origin and Mode of Induction on the Metabolic Activity of in Vitro Liver Microsomes

Abdelbaset A. Elzagallaai, Awatif M. Abuzgaia, Michael John Rieder

ca (code pays fourni par la source)

Risk and resilience in Syrian refugee children: A multisystem analysis

Demelza M. Smeeth, Andrew K. May, Elie Georges Karam, Michael John Rieder et autres

Abstract Refugee children are often exposed to substantial trauma, placing them at increased risk for mental illness. However, this risk can be mitigated by a capacity for resilience, conferred from multiple ecological systems (e.g., family, community), including at an individual biological level. …

gb, lb, ca (code pays fourni par la source)

Advancing Precision Medicine in Paediatrics: Past, present and future

Abdelbaset A. Elzagallaai, Charlotte I. S. Barker, Tamorah Rae Lewis, Ronald D. Cohn et autres

Precision Medicine is an approach to disease treatment and prevention taking into account individual genetic, environmental, therapeutic and lifestyle variability for each person. This holistic approach to therapeutics is intended to enhance drug efficacy and safety not only across healthcare systems but …

ca, gb (code pays fourni par la source)

Pathophysiology of drug hypersensitivity

Abdelbaset A. Elzagallaai, Michael John Rieder

Drug hypersensitivity reactions (DHRs) are type B adverse drug reactions (ADRs) traditionally defined as unpredictable, dose independent and not related to the drug pharmacology. DHRs, also called drug allergy if the immune system involvement is confirmed, represent around one-sixth of all ADRs …

ca (code pays fourni par la source)

War exposure, post-traumatic stress symptoms and hair cortisol concentrations in Syrian refugee children

Demelza M. Smeeth, Fiona S. McEwen, Cassandra M. Popham, Elie Georges Karam et autres

Altered secretion of cortisol, the primary effector of the hypothalamus-pituitary-adrenal axis, has been proposed as a means by which traumatic experiences compromise later mental health. However, despite the popularity of cortisol as a potential biomarker for stress and adversity, findings are inconsistent, …

gb, lb, ca (code pays fourni par la source)

The role of in vitro testing in pharmacovigilance for ß-lactam-induced serum sickness-like reaction: A pilot study

Abdelbaset A. Elzagallaai, Awatif M. Abuzgaia, Blanca R. Del Pozzo‐Magaña, Eman Loubani et autres

Background: Current pharmacovigilance (PV) methods for detection of adverse drug reactions (ADRs) fail to capture rare immune-mediated drug hypersensitivity reactions (DHRs) due to their scarcity and the lack of clear diagnostic criteria. Drug-induced serum sickness-like reactions (SSLRs) are rare type of DHRs …

ca (code pays fourni par la source)