Advancing Precision Medicine in Paediatrics: Past, present and future
Rattachement africain : ca, gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Precision Medicine is an approach to disease treatment and prevention taking into account individual genetic, environmental, therapeutic and lifestyle variability for each person. This holistic approach to therapeutics is intended to enhance drug efficacy and safety not only across healthcare systems but for individual patients. While weight and to some extent gestational age have been considered in determining drug dosing in children, historically other factors including genetic variability have not been factored into therapeutic decision making. As our knowledge of the role of ontogeny and genetics in determining drug efficacy and safety has expanded, these insights have provided new opportunities to apply principles of Precision Medicine to the care of infants, children and youth. These opportunities are most likely to be achieved first in select sub-groups of children. While there are many challenges to the successful implementation of Precision Medicine in children including the need to ensure that Precision Medicine enhances rather than reduces equity in children's health care rather, there are many more opportunities. Research, advocacy, planning and teamwork are required to move Precision Medicine forward in children in pursuit of the common goal of safe and effective drug therapy.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Advancing Precision Medicine in Paediatrics: Past, present and future
- Date Crossref
- 01/01/2023
- Éditeur
- Cambridge University Press (CUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Western University pays non établi dans la noticeUniversité ou école supérieure
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King's College London Department of Medical and Molecular Genetics pays non établi dans la noticeUniversité ou école supérieure
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University of Toronto Department of Paediatrics pays non établi dans la noticeUniversité ou école supérieure
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Hospital for Sick Children pays non établi dans la noticeÉtablissement de santé
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SickKids Foundation pays non établi dans la noticeOrganisation à but non lucratif
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University of Western Ontario Department of Physiology and Pharmacology pays non établi dans la noticeUniversité ou école supérieure
Western University, Department of Medical and Molecular Genetics — King's College London et Department of Paediatrics — University of Toronto, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.