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Robust inference and correlates from genetic associations with personality

Ted Schwaba, Margaret L. Clapp Sullivan, Wonuola A. Akingbuwa, Kerli Ilves, Peter T. Tanksley, Camille M. Williams, Yavor Dragostinov, Travis T. Mallard, Justin D. Tubbs, Wangjingyi Liao, Lindsay Ackerman, Josephine C. M. Fealy, Gibran Hemani, Javier de la Fuente, George Davey Smith, Priya Gupta, Murray B. Stein, Joel Gelernter, Daniel F. Levey, Urmo Võsa, Liisi Ausmees, Anu Realo, Tõnu Esko, Mariliis Vaht, Jüri Allïk, René Mõttus, Uku Vainik, Guðrún A. Jónsdóttir, Gudmar Thorleifsson, Árni Freyr Gunnarsson, Gyða Björnsdóttir, Thorgeir E. Thorgeirsson, Hreinn Stefánsson, Kari Stefansson, Rosa Cheesman, Qi Qin, Elizabeth C. Corfield, Helga Ask, Fartein Ask Torvik, Eivind Ystrøm, Martin Tesli, Dorret I. Boomsma, Eco J. C. de Geus, Jouke-Jan Hottenga, Dener Cardoso Melo, Harold Snieder, Catharina A. Hartman, Charley Xia, Archie Campbell, Michelle Luciano, Ian J. Deary, W. David Hill, Seon-Kyeong Jang, Scott Vrieze, Gonçalo Abecasis, Michelle K. Lupton, Brittany L. Mitchell, Petra V. Viher, Lucía Colodro‐Conde, Nicholas G. Martin, Sarah E. Medland, Eske M. Derks, Briar Wormington, Jaakko Kaprio, Karri Silventoinen, Teemu Palviainen, Agnieszka Musial, Kaili Rimfeld, Robert Plomin, Margherita Malanchini, Danielle M. Dick, Fazil Aliev, COGA Collaborators, The Spit for Science Working Group, Laura W. Wesseldijk, Fredrik Ullén, Miriam A. Mosing, Henry R. Kranzler, Yaira Nunez, S L Beck, Renato Polimanti, Tobias Edwards, Alexandros Giannelis, Emily A. Willoughby, James J. Lee, Matt McGue, Antonio Terracciano, Michele Marongiu, Edoardo Fiorillo, Francesco Cucca, Angelina R. Sutin, Peter J. van der Most, Albertine J. Oldehinkel, Tina Kretschmer, Andrey A. Shabalin, Anna R. Docherty, Robert F. Krueger, Colin D. Freilich, Binisha H. Mishra, Terho Lehtimäki, Olli T. Raitakari, Mika Kähönen, Aino Saarinen, Henrik Dobewall, Liisa Keltikangas-Järvinen, Klaus Berger, Marisol Herrera-Rivero, Fabian Streit, Swapnil Awasthi, Stephanie H. Witt, Johanna Tuhkanen, Katri Räikkönen, Johan G. Eriksson, Jari Lahti, Gail Davies, Paul Redmond, Adele Taylor, Janie Corley, Tom C. Russ, Marina Ciullo, Teresa Nutile, Jun Ding, Yong Qian, Toshiko Tanaka, Luigi Ferrucci, Lea Zillich, Lea Sirignano, K. Paige Harden, Erhan Genç, Patrick D. Gajewski, Stephan Getzmann, Christoph Fraenz, Javier E. Schneider Peñate, Stefanie Lis, Alisha S. M. Hall, Christian Schmahl, Sabine C. Herpertz, Abdel Abdellaoui, Michel G. Nivard, Elliot M. Tucker–Drob

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87Institutions associées

16Pays d’affiliation

Résumé fourni par la source

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustness, their generalizability and the biological and social pathways through which they act. Here we meta-analyse data across 46 cohorts comprising 611,037 to 1.14 million participants with European-like and African-like genomes for genome-wide association studies (GWAS) of the Big Five personality traits (extraversion, agreeableness, conscientiousness, neuroticism and openness to experience), and data from up to 50,725 participants for within-family GWAS. We identify 1,260 lead genetic variants associated with personality, including 824 novel variants3. Common genetic variants explain a moderate 4.8–9.3% of the variance in measures of each trait, and 9.3–13.3% among instruments with typical measurement reliability. Genetic associations with personality are highly consistent but not identical across geography, reporter (self versus close other), age group and measurement instrument, and we find minimal spousal assortment for personality in recent history. In contrast to many other social and behavioural traits4,5, within-family GWAS and polygenic index analyses indicate that genetic associations with personality are minimally confounded by the shared family environment. Polygenic prediction, genetic correlation and Mendelian randomization analyses indicate that personality traits have widespread, potentially causal associations with consequential behaviours and life outcomes. Overall, we find that the genetic architecture of personality is robustly generalizable, minimally confounded and widely relevant to human experience. The genetic architecture of personality is robustly generalizable, minimally confounded and widely relevant to human experience.

Institutions

Michigan State University Washington University in St. Louis Vrije Universiteit Amsterdam University of Tartu Texas State University Centre National de la Recherche Scientifique Université Paris Sciences et Lettres École Normale Supérieure - PSL Laboratoire de Sciences Cognitives et Psycholinguistique The University of Texas at Austin Broad Institute Harvard University Massachusetts General Hospital Queen Mary University of London University of Bristol Medical Research Council VA Connecticut Healthcare System VA San Diego Healthcare System Tallinn University University of Warwick University of Edinburgh Montreal Neurological Institute and Hospital McGill University deCODE Genetics (Iceland)University of Oslo Norwegian Institute of Public Health Lovisenberg Diakonale Høgskole Østfold Hospital Trust University Medical Center Groningen University of Groningen NHS Lothian Cohort (United Kingdom)Edinburgh Cancer Research University of California, Los Angeles University of Minnesota Twin Cities Orthopedics T3 Scientific (United States)Regeneron (United States)Queensland University of Technology The University of Queensland QIMR Berghofer Medical Research Institute University of Helsinki Institute for Molecular Medicine Finland King's College London Royal Holloway University of London Rutgers, The State University of New Jersey Johnson University Karolinska Institutet Max Planck Institute for Empirical Aesthetics University of Amsterdam The University of Melbourne University of Pennsylvania Yale University Erasmus University Rotterdam Florida State University Institute on Aging National Institute on Aging Institute of Genetic and Biomedical Research University of Sassari University of Utah Huntsman Cancer Institute Tampere University Fimlab (Finland)University of Turku Turku University Hospital Tampere University Hospital Tampere University Finnish Institute for Health and Welfare University of Münster Institute of Human Genetics Heidelberg University University Hospital Heidelberg Central Institute of Mental Health German Center for Infection Research Charité - Universitätsmedizin Berlin National University of Singapore Folkhälsans Forskningscentrum Alzheimer Scotland Institute of Genetics and Biophysics TU Dortmund University Leibniz Research Centre for Working Environment and Human Factors Ruhr University Bochum Aarhus University Aarhus University Hospital Amsterdam Neuroscience Bristol City Council NIHR Bristol Biomedical Research Centre

Sujets associés

Genetic Associations and EpidemiologyCognitive Abilities and TestingPersonality Traits and Psychology

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