Accès ouvert déclaré 2026 article

Genomic meta-analyses of binge-eating behavior and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes

Jet D. Termorshuizen, Helena L. Davies, Sang Hyuck Lee, Jessica K. Dennis, Christopher Hübel, Jessica S. Johnson, Yi Lu, Melissa A. Munn‐Chernoff, Triinu Peters, Baiyu Qi, Katherine E. Schaumberg, Rebecca Signer, Karanvir Singh, Abigail ter Kuile, Laura M. Thornton, Jiayi Xu, Shuyang Yao, Zeynep Yılmaz, Ruyue Zhang, Johan Zvrskovec, Mohamed Abdulkadir, Ziada Ayorech, Elizabeth C. Corfield, Alexandra Havdahl, Kristi Krebs, Taralynn Mack, Maria Niarchou, Teemu Palviainen, Julia Sealock, Jessica H. Baker, Andrew W. Bergen, Andreas Birgegård, Vesna Boraska Perica, Katharina Bühren, Roland Burghardt, Matteo Cassina, Giovanni Castellini, Enrico Collantoni, James J. Crowley, Unna N. Danner, Franziska Degenhardt, Janiece DeSocio, Christian Dina, Monika Dmitrzak‐Węglarz, Laramie E. Duncan, Karin Egberts, Lenka Foretová, Ina Giegling, Fragiskos Gonidakis, Scott D. Gordon, Jakob Grove, Sébastien Guillaume, Jerry D. Guintivano, Annette M. Hartmann, Konstantinos Hatzikotoulas, Stefan Herms, Hartmut Imgart, Susana Jiménez-Murcia, Antonio Julià, Gursharan Kalsi, Deborah Kaminská, Leila Karhunen, Hannah Kennedy, Kirsty M. Kiezebrink, Theresa Kolb, Janne T. Larsen, Dong Li, Lisa Lilenfeld, Mario Maj, Morten Mattingsdal, Paolo Meneguzzo, Allison L. Miller, Karen S. Mitchell, Alessio Maria Monteleone, Catherine M. Olsen, Leonid Padyukov, Richard Parker, Michaela Pettie, Dalila Pinto, Anu Raevuori, Samuli Ripatti, Marion Roberts, Paolo Santonastaso, Androula Savva, Ulrike H. Schmidt, Alexandra Schosser, Jochen Seitz, Lenka Šlachtová, Agnieszka Slopien, Sandro Sorbi, Péter Straub, Jin Szatkiewicz, Friederike I. Tam, Elena Tenconi, Alfonso Tortorella, Artemis Tsitsika, Annemarie Elburg, Gudrun Wagner, Hunna J. Watson, Roger A.H. Adan, Lars Alfredsson, Ole A. Andreassen, Helga Ask, Anders D. Børglum, Harry Brandt, David Collier, Steven Crawford, Scott Crow, Lea K. Davis, Martina de Zwaan, George Dedoussis, Danielle M. Dick, Stefan Ehrlich, Xavier Estivill, Angela Favaro, Fernando Fernández‐Aranda, Krista Fischer, Andreas J. Forstner, Philip Gorwood, Håkon Håkonarson, Johannes Hebebrand, Beate Herpertz-Dahlmann, Anke Hinney, James I. Hudson, Craig Johnson, Jennifer Jordan, Allan S. Kaplan, Jaakko Kaprio, Andreas Karwautz, Martien J. Kas, Walter H. Kaye, James L. Kennedy, Martin A. Kennedy, Anna Keski‐Rahkonen, Youl‐Ri Kim, Kelly L. Klump, Mikael Landén, Stéphanie Le Hellard, Kelli Lehto, Qingqin S. Li, Jolanta Lissowska, Jurjen J. Luykx, Sarah Maguire, Nicholas G. Martin, Manuel Mattheisen, Sarah E. Medland, Philip Mehler, Nadia Micali, James E. Mitchell, Palmiero Monteleone, Preben Bo Mortensen, Benedetta Nacmias, Roel A. Ophoff, Hana Papežová, Nancy L. Pedersen, Liselotte V. Petersen, Luisa S. Rajcsanyi, Nicolás Ramoz, Ted Reichborn‐Kjennerud, Valdo RICCA, Stephan Ripke, Dan Rujescu, Filip Rybakowski, Stephen W. Scherer, Margarita CT Slof-Op ‘t Landt, Howard Steiger, Patrick F. Sullivan, Beata Świątkowska, Eric F. van Furth, Tracey Wade, Thomas Werge, David C. Whiteman, D. Blake Woodside, Ya‐Ke Wu, Stephan Zipfel, Abigail R. ter Kuile, Martina de Zwaan, Estonian Biobank (EstBB), Krista Fischer, Cynthia M. Bulik, Laura M. Huckins, Gerome Breen, Jonathan R. I. Coleman

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Résumé fourni par la source

Abstract Eating disorders—including anorexia nervosa (AN), bulimia nervosa and binge-eating disorder—are clinically distinct but exhibit symptom overlap and diagnostic crossover. Genomic analyses have mostly examined AN. Here we conducted a genomic meta-analysis of case–control studies of binge-eating behavior (BE; 39,279 cases, 1,227,436 controls), alongside analyses of AN (24,223 cases, 1,243,971 controls) and its subtypes (all European ancestries). We identified six BE-associated loci, including loci associated with a higher body mass index and impulse-control behaviors. AN genome-wide association studies yielded eight loci, validating six loci. Subsequent polygenic risk score analysis demonstrated an association with AN in two East Asian ancestry studies. BE and AN exhibited similar positive genetic correlations with psychiatric disorders but opposing genetic correlations with anthropometric traits. Most of the genetic signal in BE and AN was not shared with body mass index. We have extended eating disorder genomics beyond AN; future work will incorporate multiple diagnoses and global ancestries.

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DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Genomic meta-analyses of binge-eating behavior and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes
Date Crossref: 19/08/2026
Éditeur: Springer Science and Business Media LLC
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.

Institutions déclarées

Karolinska Institutet King's College London Mental Health Services National Health Service National Institute for Health and Care Research University of British Columbia Aarhus University German Red Cross University of North Carolina at Chapel Hill Texas Tech University Essen University Hospital University of Duisburg-Essen University of Wisconsin–Madison The University of Texas at Austin Yale University Icahn School of Medicine at Mount Sinai University College London University of Oslo Norwegian Institute of Public Health University of Bristol Lovisenberg Diakonale Høgskole Lovisenberg Diakonale Sykehus University of Tartu Vanderbilt University Vanderbilt University Medical Center University of Helsinki Institute for Molecular Medicine Finland Broad Institute Film Independent Rutgers, The State University of New Jersey Oregon Research Institute University of Split Ludwig-Maximilians-Universität München Freie Universität Berlin University of Padua University of Florence Altrecht GGZ Seattle University Centre National de la Recherche Scientifique Inserm Institut du Thorax Nantes Université Poznan University of Medical Sciences Stanford University Universitätsklinikum Würzburg Reinier van Arkel Masaryk Memorial Cancer Institute Medical University of Vienna National and Kapodistrian University of Athens QIMR Berghofer Medical Research Institute Lundbeck Foundation Centre Hospitalier Universitaire de Montpellier Helmholtz Munich University of Bonn University of Basel University Hospital Bonn Life & Brain (Germany)Werner-Wicker-Klinik Instituto de Salud Carlos III Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition Bellvitge University Hospital Institut d'Investigació Biomédica de Bellvitge Ajuntament de L’Hospitalet Universitat de Barcelona Vall d'Hebron Institut de Recerca Charles University University of Eastern Finland University of Otago University of Aberdeen Technische Universität Dresden Children's Hospital of Philadelphia University of Pennsylvania The Chicago School University of Campania "Luigi Vanvitelli"Oslo University Hospital Vestre Viken Hospital Trust Boston University VA Boston Healthcare System National Center for PTSD Child Health and Development Institute Helsinki University Hospital University of Auckland Sigmund Freud Privatuniversität Wien University of Perugia Panagiotis & Aglaia Kyriakou Children's Hospital University of Applied Sciences Utrecht Utrecht University Centre for Social Innovation Curtin University University Medical Center Utrecht University of Gothenburg Centre for Palaeogenetics University of Maryland, Baltimore The Recovery Center St. Joseph Medical Center University of Minnesota New York Genome Center Medizinische Hochschule Hannover Harokopio University of Athens Quantitative BioSciences Philipps University of Marburg Forschungszentrum Jülich Université Paris Cité Centre Hospitalier Sainte-Anne Institut de Psychiatrie et Neurosciences de Paris FHU Neurovasc RWTH Aachen University McLean Hospital Canterbury Health Laboratories Canterbury District Health Board Centre for Addiction and Mental Health University of Toronto University of Groningen University of California San Diego Inje University Ilsan Paik Hospital Michigan State University University of Bergen Institut thématique Génétique, génomique et bioinformatique Janssen (United States)The Maria Sklodowska-Curie National Research Institute of Oncology Maastricht University Amsterdam University Medical Centers Cancer Institute of New South Wales Dalhousie University Queensland University of Technology The University of Queensland University of Colorado Denver Great Ormond Street Hospital University of North Dakota University of Salerno University of California, Los Angeles Charité - Universitätsmedizin Berlin Hospital for Sick Children Leiden University Medical Center GGZ Rivierduinen Douglas Mental Health University Institute McGill University Nofer Institute of Occupational Medicine Flinders University Adelaide Institute for Sleep Health University of Copenhagen University of Tübingen

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Sujets associés

Eating Disorders and BehaviorsObsessive-Compulsive Spectrum DisordersBariatric Surgery and Outcomes

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