Accès ouvert
2023
article
OpenAlex
Marta G. Silva, Reginaldo Gaspar Bastos, Jacob M. Laughery, Heba F. Alzan et autres
The apicomplexan parasite Babesia bovis is responsible for bovine babesiosis, a poorly controlled tick-borne disease of global impact. The widely conserved gametocyte protein HAPLESS2/GCS1 (HAP2) is uniquely expressed on the surface of B. bovis sexual stage parasites and is a candidate for …
us, Égypte, au
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Cynthia Onzere, Lindsay M. Fry, Richard P. Bishop, Marta G. Silva et autres
Theileria equi is a widely distributed apicomplexan parasite that causes severe hemolytic anemia in equid species. There is currently no effective vaccine for control of the parasite and understanding the mechanism that T. equi utilizes to invade host cells may be crucial …
us
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Marta G. Silva, Reginaldo Gaspar Bastos, Joseph Stone Doggett, Michael K. Riscoe et autres
Abstract Background The most common apicomplexan parasites causing bovine babesiosis are Babesia bovis and B. bigemina , while B. caballi and Theileria equi are responsible for equine piroplasmosis. Treatment and control of these diseases are usually achieved using potentially toxic chemotherapeutics, such …
us
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Marta G. Silva, Reginaldo Gaspar Bastos, Joseph Stone Doggett, Michael K. Riscoe et autres
Abstract Background: The most common apicomplexan parasites causing bovine babesiosis are Babesia bovis and B. bigemina, while B. caballi and Theileria equi are responsible for equine piroplasmosis. Treatment and control of these diseases are usually achieved using potentially toxic chemotherapeutics, such as …
us
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Marta G. Silva, Reginaldo Gaspar Bastos, Joseph Stone Doggett, Michael K. Riscoe et autres
Abstract Background: The most common apicomplexan parasites causing bovine babesiosis are Babesia bovis and B. bigemina, while B. caballi and Theileria equi are responsible for equine piroplasmosis. Treatment and control of these diseases are usually achieved using potentially toxic chemotherapeutics, such as …
us
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Marta G. Silva, Reginaldo Gaspar Bastos, Joseph Stone Doggett, Michael K. Riscoe et autres
Abstract Background: The most common apicomplexan parasites causing bovine babesiosis are Babesia bovis and B. bigemina, while B. caballi and Theileria equi are responsible for equine piroplasmosis. Treatment and control of these diseases are usually achieved using potentially toxic chemotherapeutics, such as …
us
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Carlos Esteban Suarez, Marta G. Silva, Reginaldo Gaspar Bastos, Joseph Stone Doggett et autres
Abstract Background: The most common apicomplexan parasites causing bovine babesiosis are Babesia bovis and B. bigemina, while B. caballi and Theileria equi are responsible for equine piroplasmosis. Treatment and control of these diseases are usually achieved using potentially toxic chemotherapeutics, such as …
us
(code pays fourni par la source)
Accès ouvert
2019
article
OpenAlex
Marta G. Silva, Sally A. Madsen‐Bouterse, Rohana P. Dassanayake, Michelle R. Mousel et autres
Tissue inhibitor of metalloproteinase-1 (TIMP-1) and interleukin-10 (IL-10) were identified as potential biomarkers for ovine scrapie in a mouse model. The development of novel diagnostic methods to identify pre-clinical scrapie-infected animals is needed. In this study, ELISA was used to assess TIMP-1 …
us
(code pays fourni par la source)
Accès ouvert
2019
article
OpenAlex
Carlos Esteban Suarez, Heba F. Alzan, Marta G. Silva, Vignesh Rathinasamy et autres
The global impact of bovine babesiosis caused by the tick-borne apicomplexan parasites Babesia bovis, Babesia bigemina and Babesia divergens is vastly underappreciated. These parasites invade and multiply asexually in bovine red blood cells (RBCs), undergo sexual reproduction in their tick vectors (Rhipicephalus …
us, Égypte, au
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Telmo Graça, Pei-Shin Ku, Marta G. Silva, Joshua E. Turse et autres
Anaplasma marginale is a prototypical highly antigenically variant bacterial pathogen dependent on the sequential generation of major surface protein 2 (Msp2) outer membrane variants to establish persistent infection. Msp2 is encoded by a single expression site, and diversity is achieved by gene …
us
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Marta G. Silva, Nicolás F. Villarino, Donald P. Knowles, Carlos Esteban Suarez
Babesia bovis, Babesia bigemina and Theileria equi are worldwide tick-borne hemoprotozoan that cause diseases characterized by fever, anemia, weight loss and abortion. A common feature of these diseases are transition from acute to chronic phases, in which parasites may persist in the …
us
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Marta G. Silva, Donald P. Knowles, Monica Leszkowicz Mazuz, Brian M. Cooke et autres
Babesia bigemina and Babesia bovis, are the two major causes of bovine babesiosis, a global neglected disease in need of improved methods of control. Here, we describe a shared method for the stable transfection of these two parasites using electroporation and blasticidin/blasticidin …
us, au
(code pays fourni par la source)