Reginaldo Gaspar Bastos

Safety and immunogenicity of a malignant catarrhal fever vaccine candidate expressing ovine gammaherpesvirus-2 glycoprotein B in cattle

Daniela D. Moré, Naomi S. Taus, Katherine N. K. Baker, Maria K. Herndon et autres

Background Infection of susceptible livestock species, including domestic cattle and American bison, with ovine gammaherpesvirus-2 (OvHV-2), a gammaherpesvirus in the genus Macavirus, can result in an often-fatal disease known as sheep-associated malignant catarrhal fever (SA-MCF). Prevention of SA-MCF via vaccination is a …

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Validation of an HPLC Method for the Quantification of Tafenoquine in Bovine and Equine Plasma, Red Blood Cells, and Cell Culture Media

Andrew Ursini, Madeline Duncan, Riley Golias, Julia Cutchin et autres

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First molecular detection of Theileria haneyi infection in horses in Southern Spain

Francisco J. Mendoza, Alejandro Pérez-Écija, Carlos Esteban Suarez, Esther Martínez et autres

Background Equine piroplasmosis (EP) is a tick-borne disease of equids caused by the hemoparasites Theileria equi, Babesia caballi , and Theileria haneyi . T. haneyi , a close relative of T. equi that causes mild clinical signs under experimental conditions, has been …

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Acute infection with the U.S. isolate of Theileria orientalis genotype Ikeda is associated with decreased hematocrit and erythrocyte counts in experimentally infected cattle

Cynthia Onzere, Eun‐Jee Na, David R. Herndon, Lowell S. Kappmeyer et autres

Introduction The emergence of the tick-borne Ikeda genotype of Theileria orientalis poses a significant threat to the U.S. cattle industry. Although information has been gathered on parasite distribution, data regarding the pathogenicity of the U.S. isolate of Ikeda remain to be elucidated. …

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Tafenoquine succinate inhibits the growth of the equine piroplasmosis hemoparasites Theileria equi and Babesia caballi

Natalia N. Cardillo, Nicolás F. Villarino, Lowell S. Kappmeyer, Chungwon J. Chung et autres

Abstract Background Equine piroplasmosis (EP) is a tick-borne disease of equids caused by the intraerythrocytic apicomplexan parasites Theileria equi , Babesia caballi and the recently identified Theileria haneyi . Acute cases can be severe, with anemia, jaundice, abortion or sudden death. Survivors …

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Transcriptome profiling of peripheral blood mononuclear cells from highly susceptible adult cattle infected with a virulent strain of Babesia bovis

Janaína Capelli Peixoto, Reginaldo Gaspar Bastos, Anna L. McDonald, Jacob M. Laughery et autres

BACKGROUND: Bovine babesiosis is a tick-borne disease that poses a significant economic threat to cattle industries in tropical and subtropical areas, and Babesia bovis is the most virulent causative agent of bovine babesiosis. This apicomplexan parasite infects erythrocytes of cattle, causing severe …

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A high-quality genome sequence of the equine apicomplexan hemoparasite Theileria haneyi Eagle Pass isolate

Lowell S. Kappmeyer, Malissa Grimsley, Jessica A. Hicks, Reginaldo Gaspar Bastos

ABSTRACT A high-quality genome sequence of the equine apicomplexan tickborne hemoparasite Theileria haneyi , Eagle Pass isolate, was obtained using both the Illumina Miseq and Nanopore MinION technologies. The data generated a high-quality, assembled sequence for four nuclear chromosomes, as well as …

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Tafenoquine succinate inhibits the growth of the equine piroplasmosis hemoparasites Theileria equi and Babesia caballi

Natalia N. Cardillo, Nicolás F. Villarino, Lowell S. Kappmeyer, Chungwon Chung et autres

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Elucidating the functional role of the novel BdP50 protein and extracellular vesicles in the human erythrocyte infection by Babesia divergens

Luís Miguel González, Belén Revuelta, María Carmen Terrón, Martin Sachse et autres

Babesia divergens is a blood-borne parasite that invades, replicates within and destroys red blood cells (RBCs) during its asexual life cycle, causing babesiosis in humans and cattle. This study focuses on BdP50, a putative B. divergens glycosylphosphatidylinositol-anchored protein involved in the parasite …

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Babesia ovis

Sezayi Özübek, Münir Aktaş, Reginaldo Gaspar Bastos

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Haemaphysalislongicornis ticks are unable to transstadially transmit Theileria haneyi to horses

Karen C. Poh, Kennan Oyen, Cynthia Onzere, Lowell S. Kappmeyer et autres

Introduction The recent discovery of Theileria haneyi, a tick-borne hemoparasite that causes mild clinical signs of equine piroplasmosis, has added complexity to the diagnosis of this reportable disease, which is prevalent among equids globally. Knowledge gaps regarding competent tick vectors that can …

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Structural and antigenic characterization of Babesia Bovis HAP2 domains

Mohammed M. Rahman, Heba F. Alzan, Jacob M. Laughery, Reginaldo Gaspar Bastos et autres

The tick-borne apicomplexan parasite Babesia bovis causes bovine babesiosis which leads to enormous food and economic losses around the world. The existing resources to manage this disease are limited and have pitfalls, therefore, introduction of new strategies is urgently needed. B. bovis …

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