Meng‐Yue Wang

[Anti-inflammatory constituents in Urtica dioica subsp. gansuensis, a medical plant endemic to China].

Cheng-Lin Zhou, Xiao-Bo Li, Wai Li, Yan Chen et autres

The chemical constituents in Urtica dioica subsp. gansuensis were isolated systematically and identified by preparative high performance liquid chromatography(HPLC), nuclear magnetic resonance(NMR), high-resolution mass spectrometry(HRMS), and other methods. Their anti-inflammatory activities were evaluated in vitro. As a result, 33 compounds were isolated …

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KY216-tubulin complex captures VASH2 to inhibit NSCLC metastasis

Xiaoyu He, Chengyan Liu, Qing Shun Lin, Jiafu Leng et autres

Metastasis significantly impacts the mortality rate of non-small cell lung cancer (NSCLC) patients. Numerous microtubule-targeting agents (MTAs) reveal anti-metastatic efficacy, but the mechanism remains unclear. In this research, we employ KY216, a microtubule inhibitor, to generate a crystal in complex with αβ-tubulin, …

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Six-methoxyflavone suppresses CircPIAS1 biogenesis via targeting PTBP1 and, in combination with IFN-γ, promotes ferroptosis in melanoma

Ye Guo, Xi Wu, Xin Zang, Chengyan Liu et autres

Background/Objectives Melanoma remains a highly aggressive malignancy with limited therapeutic options targeting its underlying pathogenesis. CircPIAS1 (circbase ID: hsa_circ_0008378) and its encoded protein circPIAS1-108aa contribute to tumor progression by suppressing STAT1 phosphorylation and immunogenic ferroptosis, yet specific pharmacological agents of directly targeting …

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De novo truncating variant in the FBRSL1 gene caused neurodevelopmental disorders, epilepsy, congenital heart disease, and facial dysmorphism

Dan Xu, Xiaoli Zhang, Man-Man Chu, Jiayang Xie et autres

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[A large family of Nascimento form of syndromic X-linked intellectual developmental disorder caused by large segment deletion of the UBE2A gene: a case report and literature review].

Dan Xu, Jiayang Xie, Xiaoli Zhang, Meng‐Yue Wang et autres

gene mutations (22/34, 65%) and large fragment deletions (12/34, 35%) were the main mutation types. Moderate to severe mental retardation (34/34, 100%), speech and language impairment (33/34, 97%), and unusual facies (32/34, 94%) were the main clinical manifestations of MRXSN patients. The …

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[Four new diglycosides from Momordicae Semen].

Xiaobo Li, Pei-Jun Ju, Rui Ding, Meng‐Yue Wang

The seed kernel of Momordica cochinchinensis, i.e., Momordicae Semen, is used for medicinal purposes, but to date, no research has been reported on its chemical constituents. In this study, the chemical constituents of Momordicae Semen were investigated for the first time using …

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Correction: Circular RNA-encoded oncogenic PIAS1 variant blocks immunogenic ferroptosis by modulating the balance between SUMOylation and phosphorylation of STAT1

Xin Zang, Xiaoyu He, Cheng‐Mei Xiao, Qing Shun Lin et autres

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Tongguanteng injection exerts anti-osteosarcoma effects through the ER stress-associated IRE1/CHOP pathway

Xiao-Chuan Xue, Yang-Yun Zhou, Lingyan Xu, Lan-Yi Wei et autres

BACKGROUND: In China, Tongguanteng injection (TGT) is widely used in the treatment or adjuvant treatment of various types of cancer. However, the effect and mechanism of TGT in osteosarcoma is not clear. METHODS: The 143B and MG-63 cells were treated with different …

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Acid Promoted Tetrafunctionalization of Terminal Alkynes: Geminal Diazidation and Dibromination

Zhiwu Fan, Zhiqi Li, Bao‐Yin Zhao, Meng‐Yue Wang et autres

The synthesis of complex alkanes by the tetrafunctionalization of alkynes is limited and challenging. Herein, an unprecedented efficient geminal diazidation and dibromination of terminal alkynes is developed, which provides novel access to structurally diverse organic azides. The approach has exclusive chemo- and …

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Palladium-Catalyzed Intermolecular Dehydrogenative C-2 Pentenylation of Indoles with 2-Methyl-2-butene

G. Q. Zhang, Xiao-Xuan Wu, Bao‐Yin Zhao, Meng‐Yue Wang et autres

Five-carbon (C 5 ) units are the fundamental building blocks that constitute a multitude of natural products. Herein we report an unprecedented unusual C 5 functionalization of indole regioselectively at the C-2-position enabled by a (2-pyridyl)sulfonyl-directing palladium-catalyzed dehydrogenative strategy with a bulk …

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Palladium-Catalyzed Regioselective C4-H Acyloxylation of Indoles with Carboxylic Acids via a Transient Directing Groups Strategy

Xinglong Zhang, Meng‐Yue Wang, Hui-Jin Liu, Yong‐Qiang Wang

The development of an efficient method for the synthesis of C4 oxy-substituted indoles is an appealing yet challenging task. Herein, we report a general palladium-catalyzed TDG approach for the direct C4-H acyloxylation of indoles. The protocol features atom and step economy, excellent …

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Regioselective Dehydrogenative Reverse Prenylation of Indoles with 2‐Methyl‐2‐butene

Yonghua Li, Meng‐Yue Wang, Bao‐Yin Zhao, Hongxia Zhang et autres

Bulk chemical 2-methyl-2-butene, one of the main C5 distillates of the petrochemical industry, has scarcely been utilized directly in synthesizing high-value-added fine chemicals. Herein, we use 2-methyl-2-butene as the starting material to develop a palladium-catalyzed highly site- and regio-selective C-3 dehydrogenation reverse …

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