Accès ouvert
2019
article
OpenAlex
Yuri A. Blednov, Michal Bajo, Amanda J. Roberts, Adriana J. Da Costa et autres
The voltage-gated sodium channel subunit β4 (SCN4B) regulates neuronal activity by modulating channel gating and has been implicated in ethanol consumption in rodent models and human alcoholics. However, the functional role for Scn4b in ethanol-mediated behaviors is unknown. We determined if genetic …
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Accès ouvert
2017
article
OpenAlex
Yuri A. Blednov, Mendy Black, Jillian M. Benavidez, Adriana Da Costa et autres
BACKGROUND: In our companion article, we examined the role of MyD88-dependent signaling in ethanol (EtOH) consumption in mice lacking key components of this inflammatory pathway and observed differential effects on drinking. Here, we studied the role of these same signaling components in …
us
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Accès ouvert
2017
article
OpenAlex
Yuri A. Blednov, Mendy Black, Julia Chernis, Adriana Da Costa et autres
BACKGROUND: Molecular and behavioral studies support a role for innate immune proinflammatory pathways in mediating the effects of alcohol. Increased levels of Toll-like receptors (TLRs) have been observed in animal models of alcohol consumption and in human alcoholics, and many of these …
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Accès ouvert
2016
article
OpenAlex
Jay Truitt, Yuri A. Blednov, Jillian M. Benavidez, Mendy Black et autres
Abstract Proinflammatory pathways in neuronal and non-neuronal cells are implicated in the acute and chronic effects of alcohol exposure in animal models and humans. The nuclear factor-κB (NF-κB) family of DNA transcription factors plays important roles in inflammatory diseases. The kinase IKKβ …
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Accès ouvert
2016
article
OpenAlex
Yuri A. Blednov, Mendy Black, Jillian M. Benavidez, Eleni E. Stamatakis et autres
BACKGROUND: Several peroxisome proliferator-activated receptor (PPAR) agonists reduce voluntary alcohol consumption in rodent models, and evidence suggests that PPARα and γ subunits play an important role in this effect. To define the subunit dependence of this action, we tested selective PPARα and …
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Accès ouvert
2016
article
OpenAlex
Yuri A. Blednov, Mendy Black, Jillian M. Benavidez, Eleni E. Stamatakis et autres
BACKGROUND: In the accompanying article, we showed that activation of peroxisome proliferator-activated receptor alpha (PPARα) signaling by fenofibrate and tesaglitazar decreases ethanol (EtOH) consumption in mice. In this study, we determined the role of these PPAR agonists in EtOH-related behaviors and other …
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Accès ouvert
2015
article
OpenAlex
Yuri A. Blednov, Jillian M. Benavidez, Mendy Black, Jody Mayfield et autres
us
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Accès ouvert
2015
article
OpenAlex
Yuri A. Blednov, Jillian M. Benavidez, Mendy Black, Courtney R. Leiter et autres
us
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Accès ouvert
2014
article
OpenAlex
Yuri A. Blednov, Jillian M. Benavidez, Mendy Black, Laura B. Ferguson et autres
BACKGROUND: Peroxisome proliferator-activated receptor (PPAR) agonists reduce voluntary ethanol (EtOH) consumption in rat models and are promising therapeutics in the treatment for drug addictions. We studied the effects of different classes of PPAR agonists on chronic EtOH intake and preference in mice …
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Accès ouvert
2014
article
OpenAlex
Yuri A. Blednov, Jillian M. Benavidez, Mendy Black, Robert Adron Harris
Some anti-inflammatory medications reduce alcohol consumption in rodent models. Inhibition of phosphodiesterases (PDE) increases cAMP and reduces inflammatory signaling. Rolipram, an inhibitor of PDE4, markedly reduced ethanol intake and preference in mice and reduced ethanol seeking and consumption in alcohol-preferring fawn-hooded rats …
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Accès ouvert
2014
article
OpenAlex
Yuri A. Blednov, Jillian M. Benavidez, Mendy Black, Courtney R. Leiter et autres
GABAA receptors consisting of ρ1, ρ2, or ρ3 subunits in homo- or hetero-pentamers have been studied mainly in retina but are detected in many brain regions. Receptors formed from ρ1 are inhibited by low ethanol concentrations, and family-based association analyses have linked …
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Accès ouvert
2012
article
OpenAlex
Yuri A. Blednov, Jillian M. Benavidez, Mendy Black, Dev Chandra et autres
us
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