Courtney R. Leiter

Synaptic microRNAs Coordinately Regulate Synaptic mRNAs: Perturbation by Chronic Alcohol Consumption

Dana Most, Courtney R. Leiter, Yuri A. Blednov, Robert Adron Harris et autres

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Glycine Receptors Containing α2 or α3 Subunits Regulate Specific Ethanol-Mediated Behaviors

Yuri A. Blednov, Jillian M. Benavidez, Mendy Black, Courtney R. Leiter et autres

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GABAA Receptors Containing ρ1 Subunits Contribute to In Vivo Effects of Ethanol in Mice

Yuri A. Blednov, Jillian M. Benavidez, Mendy Black, Courtney R. Leiter et autres

GABAA receptors consisting of ρ1, ρ2, or ρ3 subunits in homo- or hetero-pentamers have been studied mainly in retina but are detected in many brain regions. Receptors formed from ρ1 are inhibited by low ethanol concentrations, and family-based association analyses have linked …

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Regulation of SIK1 abundance and stability is critical for myogenesis

Randi Stewart, Dmitry Akhmedov, Christopher W. Robb, Courtney R. Leiter et autres

cAMP signaling can both promote and inhibit myogenic differentiation, but little is known about the mechanisms mediating promyogenic effects of cAMP. We previously demonstrated that the cAMP response element-binding protein (CREB) transcriptional target salt-inducible kinase 1 (SIK1) promotes MEF2 activity in myocytes …

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Systematic Identification of Functional Residues in Mammalian Histone H2AX

Wei‐Ta Chen, Amir Alpert, Courtney R. Leiter, Fade Gong et autres

The histone variant H2AX is a principal component of chromatin involved in the detection, signaling, and repair of DNA double-strand breaks (DSBs). H2AX is thought to operate primarily through its C-terminal S139 phosphorylation, which mediates the recruitment of DNA damage response (DDR) …

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