Julie Yamaguchi

Oropouche Virus in Loreto, Peru (2023–2024): Case Distribution, Genome Sequencing, and Phylogenetic Insights

Katherine Torres, Alonso Cruz-Echevarria, Lester Josue Perez, Diana Cubas et autres

Undiagnosed acute febrile illness (AFI) remains elevated in the Peruvian Amazon. The contribution of Oropouche virus (OROV) to AFI in Loreto was quantified, and its recent circulation was contextualized using targeted molecular testing and phylogenomic analysis. Using a novel research-use-only OROV real-time …

pe, us (code pays fourni par la source)

teamNGS Balances Sensitivity for Viruses with Comprehensive Microbial Detection in Clinical Specimens

Julie Yamaguchi, Gregory S. Orf, Jenna Malinauskas, Maximillian Mata et autres

Probe-based capture represents a highly sensitive and cost-effective approach for overcoming host background and enriching viruses in metagenomic NGS (mNGS) libraries. Using clinical specimens collected globally from patients with fever or respiratory illness, we generated mNGS libraries by random priming and Nextera …

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- Use of One Health centers for disease surveillance and discovery of emerging pathogens in Colombia

Karl A. Ciuoderis, Michael G. Berg, Lester Josue Perez, Abbas Hadji et autres

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Climate, inter-serotype competition and arboviral interactions shape dengue dynamics in Thailand

Lester Josue Perez, Julie Yamaguchi, Sonja L. Weiss, C eacute sar Evangelista De Menezes Carlos et autres

Abstract The incidence and global spread of dengue are reaching alarming levels. Thailand represents a critical disease epicenter and demands an understanding of the environmental and evolutionary pressures that sustain DENV transmission. Unlike most affected countries experiencing recurrent outbreaks of the same …

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P-2250. Metagenomic Next Generation Sequencing Enhances Rickettsial Infection Diagnosis in Patients with Acute Undifferentiated Fever

Sonja L. Weiss, Pakpoom Phoompoung, Julie Yamaguchi, Michael G. Berg et autres

Abstract Background Murine and scrub typhus are common causes of acute undifferentiated fever (AUF) in tropical regions, after malaria, dengue fever, and typhoid fever have been ruled out. While indirect immunofluorescence assay (IFA) can diagnose both diseases, accuracy depends on when the …

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First Evidence of Spillover of Rocahepevirus ratti Into Humans in Thailand

Julie Yamaguchi, Gregory S. Orf, Lester Josue Perez, Pakpoom Phoompoung et autres

Rocahepevirus ratti (hepatitis E virus [HEV]‐C), originally discovered in rats in 2010, has been recently linked to hepatitis in humans. Although rare and typically detected in the immunocompromised, much like Paslahepevirus balayani (HEV‐A), it can manifest as acute or persistent hepatitis. In …

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Retrospective detection of severe fever with thrombocytopenia syndrome virus (SFTSV) revises timeline of emergence in Thailand

Lester Josue Perez, Yupin Suputtamongkol, Abbas Hadji, Pakpoom Phoompoung et autres

To comprehend the time of emergence and extent of cryptic circulation for Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) in Thailand, plasma specimens collected from patients at Siriraj Hospital, Bangkok, Thailand presenting with acute undifferentiated febrile illness (AUFI) were characterized by next-generation …

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877. Diagnostic Values of Viral Target Enriched and Metagenomic NGS among Patients with Acute Undifferentiated Fever in Thailand

Julie Yamaguchi, Michael G. Berg, Sonja L. Weiss, Pakpoom Phoompoung et autres

Abstract Background Despite extensive lab testing, infectious agents were not detected in ∼50% of patients hospitalized for acute undifferentiated febrile illness (AUFI) at Siriraj Hospital, Bangkok, Thailand. Unbiased metagenomic Next Generation Sequencing (mNGS) enables detection of many microbes present in patient samples. …

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548. Target Enriched NGS Reveals Wide Breadth of Viruses Causing Acute Undifferentiated Fever in Thailand

Julie Yamaguchi, Michael G. Berg, Pakpoom Phoompoung, Jenna Malinauskas et autres

Abstract Background Despite extensive laboratory testing, infectious agents were not detected in approximately 50% of patients hospitalized for acute undifferentiated febrile illnesses (AUFI) at Siriraj Hospital, Bangkok, Thailand. Unbiased Metagenomic Next Generation Sequencing (mNGS) enables detection of any microbe present in patient …

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Oropouche virus as an emerging cause of acute febrile illness in Colombia

Karl A. Ciuoderis, Michael G. Berg, Lester Josue Perez, Abbas Hadji et autres

Arbovirus infections are frequent causes of acute febrile illness (AFI) in tropical countries. We conducted health facility-based AFI surveillance at four sites in Colombia (Cucuta, Cali, Villavicencio, Leticia) during 2019-2022. Demographic, clinical and risk factor data were collected from persons with AFI …

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A high prevalence of potential HIV elite controllers identified over 30 years in Democratic Republic of Congo

Michael G. Berg, Barbara J. Harris, Mary A. Rodgers, Linda James et autres

BACKGROUND: In-depth analysis of the HIV pandemic at its epicenter in the Congo basin has been hampered by 40 years of political unrest and lack of functional public health infrastructure. In recent surveillance studies (2017-18), we found that the prevalence of HIV …

us, République démocratique du Congo, Cameroun (code pays fourni par la source)

Advanced molecular surveillance approaches for characterization of blood borne hepatitis viruses

Michael G. Berg, Kenn Forberg, Barbara J. Harris, Julie Yamaguchi et autres

Defining genetic diversity of viral infections directly from patient specimens is the ultimate goal of surveillance. Simple tools that can provide full-length sequence information on blood borne viral hepatitis viruses: hepatitis C, hepatitis B and hepatitis D viruses (HCV, HBV and HDV) …

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