Accès ouvert
2026
article
OpenAlex
Hiroyuki Todo, Jie Yang, Tuangtong Vongpipatana, Toshiharu Shibuya et autres
Adenosine deaminase acting on RNA 1 (ADAR1), which mediates adenosine-to-inosine RNA editing, is expressed as two isoforms, p110 and p150. Deletion of Adar1 p150 in mice results in embryonic lethality caused by aberrant activation of melanoma differentiation-associated protein 5 (MDA5)-mediated sensing of …
jp, th
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Accès ouvert
2026
article
OpenAlex
Hyebin Yoo, Taisuke Nakahama, Reiichi Sugihara, Yu Gao et autres
Adenosine-to-inosine RNA editing by ADAR1 prevents aberrant innate immunity activation by modifying endogenous double-stranded RNA. Mice carrying a left-handed double-stranded RNA (Z-RNA) binding-deficient mutation develop Aicardi-Goutières syndrome (AGS)-like encephalopathy, characterized by ventricular enlargement, gliosis, calcification, and white matter degeneration with a type …
jp
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Accès ouvert
2025
article
OpenAlex
Erika Larrea, Maitena Tellaetxe-Abete, Yan Peng, Yujie Zhang et autres
RNA modifications in the brain can be essential for regulating the transcriptome and brain function. Our study unveils the landscape of different RNA modifications associated with splicing within the mouse brain. Focusing on inosine, known for its role in alternative splicing modulation …
cn, es, jp
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Accès ouvert
2024
article
OpenAlex
Kyoka Higuchi, Akiko Uyeda, Lili Quan, Shogo Tanabe et autres
Injuries to the central nervous system (CNS) can cause severe neurological deficits. Axonal regrowth is a fundamental process for the reconstruction of compensatory neuronal networks after injury; however, it is extremely limited in the adult mammalian CNS. In this study, we conducted …
jp
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Kotaro Miyake, Pedro Henrique Costa Cruz, Izumi Nagatomo, Yuki Kato et autres
-methyladenosine (m6A) modification, which affects mRNA stability. Although the METTL14 R298P mutation is found in multiple cancer types, its biological effects are not completely understood. Here, we show that the heterozygous R298P mutation promotes cancer cell proliferation, whereas the homozygous mutation reduces …
jp
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Accès ouvert
2023
article
OpenAlex
Yanfang Xing, Taisuke Nakahama, Yuke Wu, Maal Inoue et autres
Adenosine-to-inosine RNA editing is catalyzed by nuclear adenosine deaminase acting on RNA 1 (ADAR1) p110 and ADAR2, and cytoplasmic ADAR1 p150 in mammals, all of which recognize dsRNAs as targets. RNA editing occurs in some coding regions, which alters protein functions by …
jp
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Yanfang Xing, Taisuke Nakahama, Yuke Wu, Maal Inoue et autres
Abstract Adenosine-to-inosine RNA editing is catalyzed by nuclear ADAR1 p110 and ADAR2, and cytoplasmic ADAR1 p150 in mammals, all of which recognize double-stranded RNAs (dsRNAs) as targets. Although its frequency is quite rare, RNA editing occurs in coding regions, which alters protein …
jp
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Taisuke Nakahama, Yukio Kawahara
Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA-editing enzyme that catalyzes adenosine-to-inosine conversions in double-stranded RNAs (dsRNAs). In mammals, ADAR1 is composed of two isoforms: a nuclear short p110 isoform and a cytoplasmic long p150 isoform. Whereas both isoforms contain …
jp
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Masanori Yoshinaga, Kyuho Han, David W. Morgens, Takuro Horii et autres
Abstract During erythroid differentiation, the maintenance of genome integrity is key for the success of multiple rounds of cell division. However, molecular mechanisms coordinating the expression of DNA repair machinery in erythroid progenitors are poorly understood. Here, we discover that an RNA …
jp, us
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Accès ouvert
2022
article
OpenAlex
Reiichi Sugihara, Yuki Kato, Tomoya Mori, Yukio Kawahara
Global alignment of complex pseudotime trajectories between different single-cell RNA-seq datasets is challenging, as existing tools mainly focus on linear alignment of single-cell trajectories. Here we present CAPITAL (comparative analysis of pseudotime trajectory inference with tree alignment), a method for comparing single-cell …
jp
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Kyoka Higuchi, Shogo Tanabe, Yuki Kato, Akiko Uyeda et autres
Abstract Injuries to the central nervous system (CNS) can cause severe neurological deficits. Axonal regrowth is a fundamental process for the reconstruction of compensatory neuronal networks after injury; however, it is extremely limited in the adult mammalian CNS. In this study, we …
jp
(code pays fourni par la source)
2021
article
OpenAlex
Maal Inoue, Taisuke Nakahama, Ryuichiro Yamasaki, Toshiharu Shibuya et autres
Abstract Aicardi–Goutières syndrome (AGS) is a congenital inflammatory disorder accompanied by overactivated type I IFN signaling and encephalopathy with leukodystrophy and intracranial calcification. To date, none of the mouse models carrying an AGS-causative mutation has mimicked such brain pathology. Here, we established …
jp
(code pays fourni par la source)