Shau-Hsuan Li

Outcomes and Predictors of Mortality Following Veno-Arterial Extracorporeal Membrane Oxygenation

Di Huang, Meng‐Yun Tsai, Hsing-Hua Lai, Y S Chen et autres

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Macrocytosis as a risk factor for secondary esophageal cancer in hypopharyngeal cancer patients: a multicenter case–control study

Ching‐Nung Wu, Po-Teng Chiang, Chung‐Yi Li, Jo-Chi Chin et autres

Background: Identification of hypopharyngeal cancer (HPC) patients at heightened risk for developing metachronous second primary esophageal cancer (MSPEC) is crucial for the optimization of screening protocols and thus survival improvement. Although mean corpuscular volume (MCV) is recognized as a biomarker for esophageal …

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The association of organophosphate flame retardants (OPFRs) exposure on omega-3 fatty acids metabolism: evidence derived from the United States general population

Ting-Hsuan Hsu, Hsiu-Yung Pan, Kai‐Fan Tsai, Chia‐Te Kung et autres

This study investigated the association between exposure to organophosphate flame retardants (OPFRs) and serum omega-3 fatty acid levels in the general U.S. population, using data from 1,350 adults in the 2011-2014 National Health and Nutrition Examination Survey (NHANES). OPFRs are widely used …

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Patient-reported outcomes between proton and photon therapy in nasopharyngeal carcinoma patients: A longitudinal cohort study

Ching‐Nung Wu, Yu‐Ming Wang, Wei‐Chih Chen, Yun‐Hsuan Lin et autres

Background and purpose: This study aimed to compare patient-reported outcomes (PROs) between intensity-modulated proton therapy (IMPT) and volumetric-modulated arc therapy (VMAT) in treating nasopharyngeal carcinoma (NPC). Materials and methods: A prospective cohort study was conducted at a tertiary care center from 2021 …

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Aldo-keto reductase family 1 member B10 prevents esophageal squamous cell carcinoma from reactive carbonyl species-induced cell death and promotes its progression

Shau-Hsuan Li, Wan‐Ting Huang, Yen‐Hao Chen, Hung‐I Lu et autres

INTRODUCTION: Chronic alcohol consumption and tobacco usage are major risk factors for esophageal squamous cell carcinoma (ESCC). Excessive tobacco and alcohol consumption lead to oxidative stress and the generation of reactive carbonyl species (RCS) which induce DNA damage and cell apoptosis. This …

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Hypoalbuminemia is Associated with Higher 90-Day Mortality and Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma and Liver Cirrhosis Receiving Radiotherapy-Based Therapy

Yu-Yang Hua, Ming‐Chun Kuo, Yen‐Hao Chen, Hung‐I Lu et autres

Background: Liver cirrhosis (LC) is common among patients with esophageal squamous cell carcinoma (ESCC) due to shared etiologic factor, alcohol. For non-metastatic ESCC (nmESCC) patients with cirrhosis, surgery is often contraindicated or associated with high morbidity, therefore radiotherapy-based therapy was commonly applied. …

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Effects of urinary organophosphate flame retardants in susceptibility to attention-deficit/hyperactivity disorder in school-age children

Liang‐Jen Wang, How‐Ran Chao, Chih‐Cheng Chen, Huey‐Ling You et autres

exposure scenarios, and urinary phthalate metabolites, parabens, bisphenol-A and creatinine, levels of urinary BDCPP, TDCPP, and TBEP in ADHD children showed significant and dose-dependent effects on core behavioral symptoms of inattention. DNBP levels were positively correlated with neuropsychological deficits (CPT detectability, omission, …

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Does liver cirrhosis affect outcomes in non-metastatic esophageal squamous cell carcinoma (ESCC) undergoing radiotherapy-based treatment?

Yu-Yang Hua, Shih Yu Huang, Shau-Hsuan Li

89 Background: Liver cirrhosis frequently coexists with esophageal squamous cell carcinoma (ESCC), as both conditions share alcohol consumption as a common etiological factor. Surgical intervention is often contraindicated or associated with significant morbidity in patients with non-metastatic ESCC and liver cirrhosis. Consequently, …

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Preoperative neutrophil–to–lymphocyte ratio after chemoradiotherapy for esophageal squamous cell carcinoma associates with postoperative pulmonary complications following radical esophagectomy

Chien-Ming Lo, Hung‐I Lu, Yu‐Ming Wang, Yen‐Hao Chen et autres

OBJECTIVES: Esophagectomy after chemoradiotherapy is associated with an increased risk of surgical complications. The significance of preoperative neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio after chemoradiotherapy in predicting pulmonary complications following radical esophagectomy in esophageal squamous cell carcinoma patients receiving preoperative chemoradiotherapy remains unknown. …

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The risk of free flap revision and subsequent medical costs in patients with hypopharyngeal cancer

Chun-Hsien Ho, Sheng‐Dean Luo, Wei‐Chih Chen, Tai‐Jan Chiu et autres

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Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomised, double-blind, phase 3 trial

Jean‐Pascal Machiels, Yungan Tao, Lisa Licitra, Barbara Burtness et autres

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Association between organophosphate flame retardant exposure and lipid metabolism: data from the 2013–2014 National Health and Nutrition Examination Survey

Fu‐Jen Cheng, Kai‐Fan Tsai, Kuo‐Chen Huang, Chia‐Te Kung et autres

Organophosphate flame retardants (OPFRs) are emerging environmental pollutants that can be detected in water, dust, and biological organisms. Certain OPFRs can disrupt lipid metabolism in animal models and cell lines. However, the effects of OPFRs on human lipid metabolism remain unclear. We …

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