Accès ouvert
2026
article
OpenAlex
Tz-You Chen, Lay San Lim, Yen‐Hao Chen, Yi‐Chia Chan et autres
Background: Locally advanced thyroid cancer is associated with a poor prognosis and high surgical morbidity. This study evaluated the feasibility and outcomes of neoadjuvant treatment including targeted therapy with locoregional interventions. Methods: We retrospectively analyzed 17 patients with locally advanced thyroid cancer …
tw
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Hao‐Lun Luo, Yi Yang Liu, Hui Ying Liu, Yu Li Su et autres
BACKGROUND: This study examined oncologic outcomes associated with Radium-223 (Ra-223) administered at different treatment lines in patients with metastatic castration-resistant prostate cancer (mCRPC) with bone metastases, and evaluated the prognostic implications of biomarker responses-particularly prostate-specific antigen (PSA) and alkaline phosphatase (ALP)-during Ra-223 …
tw, jp
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Yuan‐Hung Kuo, Wei Teng, Yen‐Hao Chen, Po‐Ting Lin et autres
Background and Aims: The prognostic nutritional index (PNI), calculated from serum albumin and lymphocyte count, reflects a patient's immune-nutritional status and has been proposed as a prognostic marker in hepatocellular carcinoma (HCC). However, its role in advanced HCC patients treated with atezolizumab …
tw
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Yuan‐Hung Kuo, Wei Teng, Po‐Ting Lin, Yen‐Hao Chen et autres
INTRODUCTION: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality, particularly in patients with advanced stage. Atezolizumab plus bevacizumab (Ate/Bev) is the standard first-line therapy; however, its efficacy may be further enhanced using combination strategies. METHODS: This study evaluated the clinical …
tw
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Chieh-Min Liu, Chia‐Hsuan Lai, Yu‐Ming Wang, Eng-Yen Huang et autres
Background: Patients with hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) have poor outcomes and limited treatment options. Clinical data specifically evaluating the effects of intensity-modulated proton therapy (IMPT) for this population remain scarce. We reported the outcomes of patients with …
tw
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Ching-Di Chang, Yen‐Hao Chen, Ming‐Chao Tsai, Jing‐Houng Wang et autres
Background/Aims: Muscle volume loss (MVL) is associated with poor outcomes in patients with hepatocellular carcinoma (HCC). However, dynamic muscle atrophy during HCC treatment is also a critical concern. This study aimed to determine the clinical significance of MVL and severe muscle atrophy …
tw
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Accès ouvert
2025
article
OpenAlex
Takuya Oishi, Hao‐Lun Luo, Yoshiomi Hatayama, Hideo Kawaguchi et autres
The risk factors for adium-233 dichloride (Ra223) treatment on prognosis remain unclear. We aimed to validate the risk model for a radium-233 dichloride (Ra223) on the prognosis of patients with metastatic castration-resistant prostate cancer (mCRPC). We retrospectively evaluated 345 patients with bone …
jp, tw
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Yen‐Hao Chen
BRAF V600E is the most common oncogenic mutation in papillary thyroid carcinoma (PTC). This study aimed to assess the clinical outcomes of combining dabrafenib and trametinib in patients with BRAF V600E-mutant PTC. Patients with BRAF V600E-mutant PTC treated with dabrafenib and trametinib …
tw
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Shau-Hsuan Li, Wan‐Ting Huang, Yen‐Hao Chen, Hung‐I Lu et autres
INTRODUCTION: Chronic alcohol consumption and tobacco usage are major risk factors for esophageal squamous cell carcinoma (ESCC). Excessive tobacco and alcohol consumption lead to oxidative stress and the generation of reactive carbonyl species (RCS) which induce DNA damage and cell apoptosis. This …
tw
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Accès ouvert
2024
article
OpenAlex
Yu-Yang Hua, Ming‐Chun Kuo, Yen‐Hao Chen, Hung‐I Lu et autres
Background: Liver cirrhosis (LC) is common among patients with esophageal squamous cell carcinoma (ESCC) due to shared etiologic factor, alcohol. For non-metastatic ESCC (nmESCC) patients with cirrhosis, surgery is often contraindicated or associated with high morbidity, therefore radiotherapy-based therapy was commonly applied. …
tw
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Kuan-Chang Lai, Yen‐Hao Chen, Yi-Ping Hung, Nai-Jung Chiang et autres
BACKGROUND/PURPOSE: Recently, anti-programmed cell death protein-1 (anti-PD-1) and anti-PD-L1 therapies were approved for hepatocellular carcinoma (HCC). However, the effectiveness of rechallenging with one immune checkpoint inhibitor (ICI) after failure of another remains unclear. This study explores the efficacy and safety of anti-PD-L1 …
tw
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Yuyin Liu, Ming-Yen Tsai, Tingting Liu, Yueh-Wei Liu et autres
BACKGROUND: The aim of this study is to investigate the real-world efficacy and safety of nivolumab in combination with chemotherapy for patients with advanced human epidermal growth factor receptor 2 (HER2)-negative gastric cancer (GC). METHODS: We enrolled patients diagnosed with unresectable advanced …
tw
(code pays fourni par la source)