Geoffrey W. Butcher

Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway

Ann Y. Park, Michael Leney-Greene, Matthew Lynberg, Justin Q. Gabrielski et autres

us, de, gb, tr, at, fr (code pays fourni par la source)

GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway

Ann Y. Park, Michael Leney-Greene, Matthew Lynberg, Justin Q. Gabrielski et autres

us, de, gb, tr, at, fr (code pays fourni par la source)

GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans

Yikun Yao, Ping Jiang, Brittany Chao, Deniz Çağdaş et autres

Inborn errors of immunity (IEIs) unveil regulatory pathways of human immunity. We describe a new IEI caused by mutations in the GTPase of the immune-associated protein 6 (GIMAP6) gene in patients with infections, lymphoproliferation, autoimmunity, and multiorgan vasculitis. Patients and Gimap6-/- mice …

us, gb, tr, de, au, il (code pays fourni par la source)

GIMAP6 is required for T cell maintenance and efficient autophagy in mice

John C. Pascall, Louise M. C. Webb, Eeva‐Liisa Eskelinen, Silvia Innocentin et autres

The GTPases of the immunity-associated proteins (GIMAP) GTPases are a family of proteins expressed strongly in the adaptive immune system. We have previously reported that in human cells one member of this family, GIMAP6, interacts with the ATG8 family member GABARAPL2, and …

gb, fi, fr (code pays fourni par la source)

Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice

Preeta Datta, Louise M. C. Webb, Inxhina Avdo, John C. Pascall et autres

An effective immune system depends upon the survival of mature T cells in the periphery. Members of the GIMAP family of GTPases have been proposed to regulate this homeostasis, supported by the paucity of peripheral T cells in rodents deficient for either …

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GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo

Louise M. C. Webb, Preeta Datta, Sarah E. Bell, Daisuke Kitamura et autres

An effective immune system depends upon regulation of lymphocyte function and homeostasis. In recent years, members of the GTPases of the immunity associated protein (GIMAP) family were proposed to regulate T cell homeostasis. In contrast, little is known about their function and …

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Generation and Characterisation of Mice Deficient in the Multi-GTPase Domain Containing Protein, GIMAP8

Louise M. C. Webb, John C. Pascall, Lucy Hepburn, Christine Carter et autres

BACKGROUND: GTPases of the immunity-associated protein family (GIMAPs) are predominantly expressed in mature lymphocytes. Studies of rodents deficient in GIMAP1, GIMAP4, or GIMAP5 have demonstrated that these GTPases regulate lymphocyte survival. In contrast to the other family members, GIMAP8 contains three potential …

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The miR-155–PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation

Dong Lu, Rinako Nakagawa, Sandra Lazzaro, Philipp Staudacher et autres

A single microRNA (miRNA) can regulate the expression of many genes, though the level of repression imparted on any given target is generally low. How then is the selective pressure for a single miRNA/target interaction maintained across long evolutionary distances? We addressed …

gb, dk, mx, au (code pays fourni par la source)

G imap3 and G imap5 cooperate to maintain T ‐cell numbers in the mouse

Kouta Yano, Christine Carter, Naofumi Yoshida, Takaya Abe et autres

Gimap3 (IAN4) and Gimap5 (IAN5) are highly homologous GTP-binding proteins of the Gimap family. Gimap3 and Gimap5, whose transcripts are abundant in mature lymphocytes, can associate with antiapoptotic Bcl-2 family proteins. While it is established that Gimap5 regulates T-cell survival, the in …

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The Immune System GTPase GIMAP6 Interacts with the Atg8 Homologue GABARAPL2 and Is Recruited to Autophagosomes

John C. Pascall, Sergio Rotondo, Aamir S. Mukadam, David Oxley et autres

The GIMAPs (GTPases of the immunity-associated proteins) are a family of small GTPases expressed prominently in the immune systems of mammals and other vertebrates. In mammals, studies of mutant or genetically-modified rodents have indicated important roles for the GIMAP GTPases in the …

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Mice Lacking Ly49E Show Normal NK Cell Development and Provide Evidence for Probabilistic Expression of Ly49E in NK Cells and T Cells

Jonathan G. Aust, Frances Gays, Farhana Hussain, Geoffrey W. Butcher et autres

Ly49E is an unusual member of the Ly49 family that is expressed on fetal NK cells, epithelial T cells, and NKT cells, but not on resting adult NK cells. Ly49E(bgeo/bgeo) mice in which the Ly49E gene was disrupted by inserting a β-geo …

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The autoimmunity-related GIMAP5 GTPase is a lysosome-associated protein

Vivian W.Y. Wong, Amy Saunders, Amanda Hutchings, John C. Pascall et autres

A mutation in the rat GIMAP5 gene predisposes for autoimmunity, most famously in the BB rat model of autoimmune type 1 diabetes mellitus. This mutation is associated with severe peripheral T lymphopenia, as is mutation of the same gene in mice, but …

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