Rinako Nakagawa

Comparative inhibitory effects of bepotastine and diphenhydramine on rituximab-induced infusion reactions

Tomoki Hori, Kazuhiro Yamamoto, Tomoaki Nakagawa, Rinako Nakagawa et autres

PURPOSE: Infusion-related reaction (IRR) is a common adverse event induced by rituximab. Although first-generation histamine 1 receptor antagonists (H1RAs) are commonly used to prevent IRR, evidence on IRR suppression by the second-generation H1RA bepotastine is scarce. In this study, we assessed the …

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Epi-microRNA mediated metabolic reprogramming counteracts hypoxia to preserve affinity maturation

Rinako Nakagawa, Miriam Llorian, Sunita Varsani-Brown, Probir Chakravarty et autres

To increase antibody affinity against pathogens, positively selected GC-B cells initiate cell division in the light zone (LZ) of germinal centers (GCs). Among these, higher-affinity clones migrate to the dark zone (DZ) and vigorously proliferate by utilizing energy provided by oxidative phosphorylation …

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Comparison of the inhibitory effects between bepotastine and diphenhydramine on rituximab-induced infusion-related reactions: A single-center retrospective study

Tomoki Hori, Kazuhiro Yamamoto, Tomoaki Nakagawa, Rinako Nakagawa et autres

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Regulation of BCR-mediated Ca 2+ mobilization by MIZ1-TMBIM4 safeguards IgG1 + GC B cell–positive selection

Lingling Zhang, Amparo Toboso-Navasa, Arief Suryono Gunawan, Abdouramane Camara et autres

The transition from immunoglobulin M (IgM) to affinity-matured IgG antibodies is vital for effective humoral immunity. This is facilitated by germinal centers (GCs) through affinity maturation and preferential maintenance of IgG + B cells over IgM + B cells. However, it is …

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Editorial: Molecular and cellular control of B cell responses: germinal center and extrafollicular responses for cellular outputs

Rinako Nakagawa, Dessislava Malinova, Manuel D. Díaz‐Muñoz

International audience

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mTORC1-selective activation of translation elongation promotes disease progression in chronic lymphocytic leukemia

Natasha Malik, Jodie Hay, Hassan N. B. Almuhanna, Karen M. Dunn et autres

Abstract Targeted deletion of Raptor, a component of mechanistic target of rapamycin complex 1 (mTORC1), reveals an essential role for mTORC1 in initiation/maintenance of leukemia in a CLL model, resulting from a failure for haemopoietic stem/progenitor cells (HSPCs) to commit to the …

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Epi-microRNA mediated metabolic reprogramming ensures affinity maturation

Rinako Nakagawa, Miriam Llorian, Sunita Varsani-Brown, Probir Chakravarty et autres

To increase antibody affinity against pathogens, positively selected GC-B cells initiate cell division in the light zone (LZ) of germinal centres (GCs). Among those, higher-affinity clones migrate to the dark zone (DZ) and vigorously proliferate by relying on oxidative phosphorylation (OXPHOS). However, …

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Regulation of BCR-mediated Ca 2+ mobilization by MIZ1-TIMBIM4 safeguards IgG1 + GC B cell positive selection

Lingling Zhang, Amparo Toboso-Navasa, Arief Suryono Gunawan, Abdouramane Camara et autres

Summary The transition from IgM to affinity-matured IgG antibodies is vital for effective humoral immunity. This is facilitated by germinal centers (GCs) through affinity maturation and preferential accumulation of IgG + B cells over IgM + B cells. However, it is not …

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mTORC1 activity is essential for disease progression in chronic lymphocytic leukemia

Natasha Malik, Jodie Hay, Karen M. Dunn, Rinako Nakagawa et autres

Abstract The precise role of mechanistic target of rapamycin complex 1 (mTORC1) during chronic lymphocytic leukemia (CLL) pathogenesis remains to be elucidated. Targeted deletion of mTORC1 component Raptor in adult mice reveals that mTORC1 function is essential for initiation and maintenance of …

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Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts

Marlene Corbet, Miguel A. Pineda, Kun Yang, Anuradha Tarafdar et autres

ES-62 is the major secreted protein of the parasitic filarial nematode, Acanthocheilonema viteae. The molecule exists as a large tetramer (MW, ~240kD), which possesses immunomodulatory properties by virtue of multiple phosphorylcholine (PC) moieties attached to N-type glycans. By suppressing inflammatory immune responses, …

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Positive Selection in the Light Zone of Germinal Centers

Rinako Nakagawa, Dinis Pedro Calado

Germinal centers (GCs) are essential sites for the production of high-affinity antibody secreting plasma cells (PCs) and memory-B cells (MBCs), which form the framework of vaccination. Affinity maturation and permissive selection in GCs are key for the production of PCs and MBCs, …

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Permissive selection followed by affinity-based proliferation of GC light zone B cells dictates cell fate and ensures clonal breadth

Rinako Nakagawa, Amparo Toboso-Navasa, Marta Schips, George R. Young et autres

Significance Light zone (LZ) B cells are selected in germinal centers (GCs) in a cMyc-dependent manner, before dark zone (DZ) migration. Antigen affinity of B cells is enhanced during GC responses, and some differentiate into plasmablasts or memory B cells (MBCs). Currently, …

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