Lucy Hepburn

Anaesthesia for Cardiac Surgery in Children

Lucy Hepburn

As antenatal diagnosis improves and surgical techniques are developed, the paediatric cardiac anaesthetist has an increasing role in the multidisciplinary team looking after the child undergoing cardiac surgery. Successful major operations in the neonatal period require balancing circulation and managing inotropy, coagulation …

Enhanced recovery after paediatric cardiac surgery

Lorraine W. Foote, Lucy Hepburn, C Goodison

gb (code pays fourni par la source)

Predicting Peri-Operative Cardiorespiratory Adverse Events in Children with Idiopathic Pulmonary Arterial Hypertension Undergoing Cardiac Catheterization Using Echocardiography: A Cohort Study

Timothy J. W. Dawes, Valentine Woodham, Emma Sharkey, Angus McEwan et autres

Abstract General anesthesia in children with idiopathic pulmonary arterial hypertension (PAH) carries an increased risk of peri-operative cardiorespiratory complications though risk stratifying individual children pre-operatively remains difficult. We report the incidence and echocardiographic risk factors for adverse events in children with PAH …

gb (code pays fourni par la source)

Anesthesia for Transposition of the Great Arteries

Valentine Woodham, Mariepi Manolis, Lucy Hepburn, Angus McEwan

Transposition of the great arteries (TGA) refers to a spectrum of conditions of discordant ventriculoarterial (VA) connections, which is divided into two key types: dextro-looped (d-TGA) and levo-looped (l-TGA or ccTGA). Advances in perioperative and surgical care in the past two decades …

gb (code pays fourni par la source)

Multicentre study of appendicitis management comparing a large South Island metropolitan hospital, to its referring regional and rural centres

Nicole Withers, Lucy Hepburn, Jethro Palmer, Fergus Evans et autres

BACKGROUND: Globally, patients presenting with acute surgical disease in rural areas have poorer outcomes when compared to urban areas; little data are available regarding outcomes for New Zealand (NZ) rural patients. This study aimed to compare the surgical management of appendicitis in …

nz, Afrique du Sud (code pays fourni par la source)

90 Anaesthetic and peri-operative complications in paediatric patients with brugada syndrome

Jo Han Gan, Sri Anita, Juan Pablo Kaski, Lucy Hepburn et autres

Background Brugada syndrome (BrS) is a cardiac ion channelopathy, typically affecting autosomal-dominantly inherited mutations in the SCN5A gene. BrS predisposes to potentially malignant arrhythmias and sudden cardiac death. Routinely administered anaesthetic drugs may trigger malignant arrhythmias in susceptible individuals. This is the …

gb (code pays fourni par la source)

109 Deconstructing Fear

Harriet Carver, Mike Stylianou, Sarah Regan, M D Cohen et autres

Over 18, 500 children and young people (CYP) come to Great Ormond Street for surgery each year, 50% of these will develop procedural anxiety prior to surgery, and this may be fleeting and transient or long lasting. ‘Deconstructing Fear’ is intended to …

gb, us (code pays fourni par la source)

77 Deconstructing fear – a solution

Mike Stylianou, Lucy Hepburn, Harriet Carver, Sarah Regan

Approx 800,000 children in the UK present for have surgery every year This number is rising by approx. 11% per annum. Evidence suggests that up to 75% of these CYP’s will experience anxiety on hospitalisation. This procedural anxiety may be fleeting and …

gb (code pays fourni par la source)

Cardiac transplantation in children

Colin Black, Abbas Khushnood, Helen Holtby, Lucy Hepburn

gb, ca (code pays fourni par la source)

076 Dexmedetomidine sedation to facilitate CT coronary angiography in children: a novel approach

Chet A. Morrison, Lucy Hepburn, Grant Stuart

Introduction Dexmedetomidine has been proven to provide safe and reliable sedation in children and is a viable option for radiological imaging studies. No previous studies describe the use of Dexmedetomidine for CT coronary angiography, to provide safe sedation in combination with a …

The complex biology and contribution ofStaphylococcus aureusin atopic dermatitis, current and future therapies

Lucy Hepburn, DirkJan Hijnen, Bret R. Sellman, Tomas Mustelin et autres

Atopic dermatitis (AD) is a complex, chronic inflammatory skin disorder affecting more than 10% of U.K. children and is a major cause of occupation-related disability. A subset of patients, particularly those with severe AD, are persistently colonized with Staphylococcus aureus and exacerbation …

gb, nl, us (code pays fourni par la source)

Functional drug screening reveals anticonvulsants as enhancers of mTOR‐independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

Mark Schiebler, Karen Brown, Krisztina Hegyi, Sandra M. Newton et autres

Mycobacterium tuberculosis (MTB) remains a major challenge to global health made worse by the spread of multidrug resistance. We therefore examined whether stimulating intracellular killing of mycobacteria through pharmacological enhancement of macroautophagy might provide a novel therapeutic strategy. Despite the resistance of …

gb, pt, my, us (code pays fourni par la source)