Voja Pavlović

Concentrated growth factors: basic characteristics and clinical application

Voja Pavlović, Jelena Vučić, Milena Trandafilović

Introduction: The beneficial activity of platelet concentrates (PC), during healing process is mainly attributed to the regenerative potential of growth factors (GF) released from platelets. Since concentrated growth factor (CGF) possesses great regenerative properties, in recent years has gained increased attention for …

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Hypoplastic arteries of the cerebral arterial ring in the blind spot of computed tomography angiography

Milena Trandafilović, Miroslav Milić, Aleksandra Antović, Ivan C. Stojanovic et autres

BACKGROUND: Some variations of the cerebral arterial circle (CAC) are associated with an increased risk for the development of various pathological conditions. This paper aimed to determine the prevalence of hypoplastic arteries of CAC and to emphasize the limited possibility of their …

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Vitamin C and epigenetics: A short physiological overview

Voja Pavlović, Milan Ćirić, Milan Petković, Mlađjan Golubović

In recent years, ascorbic acid (vitamin C) has acquired great interest due to its multiple functions, which results in homeostasis of normal tissues and organs. On the other hand, it has been shown that epigenetic modifications may have an important role in …

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Platelet-rich fibrin: Basics of biological actions and protocol modifications

Voja Pavlović, Milan Ćirić, Vladimir M Jovanovic, Milena Trandafilović et autres

Platelet-rich fibrin (PRF) represents second generation of platelet concentrates, which has gained increasing awareness in recent years for regenerative procedures. This biologic additive is completely autologous, easy to prepare, has minimal expense, and possesses prolonged growth factor release, together with several other …

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EFFECT OF CURCUMIN AND P53 SIGNALING PATHWAY IN RAT THYMOCYTES TOXICITY INDUCED BY MANCOZEB

Voja Pavlović, Snežana Cekić, Maja Petrović

Mancozeb, as a dithiocarbamate fungicide, is widely used in agriculture due to its low acute toxicity and short environmental persistence.We examined the protective role of curcumin on Mancozeb-induced toxicity in rat thymocytes and potential mechanisms involved.Rat thymocytes were exposed to Mancozeb (0.01 …

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LOCAL THERAPY WITH IMIQUIMOD AS A POSSIBLE MEDICAL TREATMENT OF VULVAR INTRAEPITHELIAL NEOPLASMS

Dane Krtinić, Radomir Živadinović, Biljana Živadinović, Zorica Jović et autres

Imiquimod is a local immunomodulator with antiviral effects.Vulvar intraepithelial neoplasia is a chronic precancerous condition of the skin of the vulva, with different malignant potential and clinical course.The aim of the paper was to determine therapeutic effects of Imiquimod in treating different …

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PRIMENA HORMONA U INDUKCIJI I SINHRONIZACIJI ESTRUSA I OVULACIJE KOD KRAVA

Voja Pavlović, M. Maletić, Slobodanka Vakanjac, Marko Pavlović et autres

Imajući u vidu značaj i obim stočarske proizvodnje, nameće se pitanje praćenjazdravlja i plodnosti u zapatima krava. Visoka produktivnost povlači za sobomnegativne efekte na plodnost, pa tako između proizvodnje mleka i plodnosti postoji„borba za primat”. Jedan od načina borbe za što bolju …

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Modulatory effect of curcumin on ketamine-induced toxicity in rat thymocytes: Involvement of reactive oxygen species (ROS) and the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway

Svetlana Jovicic Pavlovic, Zorica Jović, Radmila Karan, Dane Krtinić et autres

Ketamine is a widely used anesthetic in pediatric clinical practice. Previous studies have demonstrated that ketamine induces neurotoxicity and has a modulatory effect on the cells of the immune system. Here, we evaluated the potential protective effect and underlying mechanisms of natural …

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Therapeutic role of methotrexate in pediatric Crohn’s disease

Zlatko Djurić, Ljiljana Šaranac, Ivana Budić, Voja Pavlović et autres

The main role of therapy in Crohn's disease (CD) is to achieve long-term clinical remission, and to allow for normal growth and development of children. The immunomodulatory drugs used for the maintenance of remission in CD include thiopurines (azathioprine and 6-mercaptopurine) and …

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The effect of curcumin and PI3K/Akt inhibitor on monosodium glutamate-induced rat thymocytes toxicity

Miodrag Vučić, Irena Ćojbašić, Jelena Vučić, Voja Pavlović

Monosodium glutamate (MSG), the sodium salt of glutamic acid, is widely used in modern nutrition as flavor enhancer. However, it has been shown that curcumin has ability to induce apoptosis in the cells of the immune system. In the present study, we …

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Evaluation of platelet activation during storage in leukocyte-depleted platelet concentrates

Miodrag Vučić, Zoran Stanojković, Ana Antić, Jelana Vucic et autres

Structural and functional changes in platelets during storage can lead to the loss of platelet reactivity and response. Our aim was to evaluate leukocyte-depleted platelet concentrates on storage days 0, 3 and 5, obtained by in-line filtration. In non-filtered platelet concentrates (NF-PC) …

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Curcumin attenuates Mancozeb-induced toxicity in rat thymocytes through mitochondrial survival pathway

Voja Pavlović, Snežana Cekić, Milan Ćirić, Dane Krtinić

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