Miodrag Vučić

Integrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets

Shih-Chun A. Chu, Yi Hsiao, Chenwei Wang, Jennifer E. Kyle et autres

Acute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous hematological malignancy. Here, to better define this clinically taxing and translationally challenging malignancy, we applied a multiomics approach, consisting of 13 modalities to analyze 173 treatment-naive individuals with AML. By integrating these …

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CHARACTERISTICS AND MANAGEMENT OF PATIENTS WITH MULTIPLE MYELOMA: A SINGLE-CENTER EXPERIENCE

Ina Konstantinović, Irena Ćojbašić, Miodrag Vučić

Multiple myeloma is the second most common hematological malignancy in which pathological plasma cells secrete monoclonal proteins, ultimately leading to end-organ damage. Albumin, β2-microglobulin, and LDH are considered highly relevant biomarkers for the diagnosis and prognosis of this disease. There are different …

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ASSESSMENT OF TREATMENT OUTCOMES IN MULTIPLE MYELOMA ACCORDING TO PROGNOSTIC FACTORS AND THERAPEUTIC APPROACH

Dragana Drašković, Goran Marjanović, Miodrag Vučić, Irena Ćojbašić

Multiple myeloma is a malignant plasma cell disorder characterized by clonal proliferation of abnormal plasma cells. Global five-year survival rates range from 60% to 70%, largely due to novel therapeutic strategies. In our country, conventional therapies remain standard, with monoclonal antibodies recently …

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ENZYME REPLACEMENT THERAPY IN PATIENTS WITH TYPE 1 GAUCHER DISEASE: A SINGLE-CENTER EXPERIENCE

Ivana Golubović, Miodrag Vučić, Irena Ćojbašić, Milan Lazarević et autres

Gaucher disease (GD) is a liposomal storage disorder inherited in an autosomal recessive pattern.The underlying cause of the disease is a mutation within the gene that encodes the enzyme glucocerebrosidase.Accumulation of glucocerebrosidase in macrophages in the liver, spleen, bone marrow, rarely in …

THROMBOPOIETIN RECEPTOR AGONISTS IN THE TREATMENT OF PRIMARY IMMUNE THROMBOCYTOPENIA: OUR EXPERIENCE

Ivana Golubović, Miodrag Vučić, Irena Ćojbašić, Ivan Tijanić et autres

The primary immuna thrombocytopenia (ITP) is an acquired autoimmune disease characterized by isolated thrombocytopenia PLT < 100 x 10 9 /L, and the absence of all conditions and diseases that can result in thrombocytopenia.The first-line therapy in ITP involves the use of …

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GAUCHER DISEASE TYPE 1 AND GASTRIC CANCER: A CASE REPORT

Ivana Golubović, Miodrag Vučić, Goran Marjanović, Irena Ćojbašić et autres

Gaucher disease (GD is a liposomal storage disease that is inherited in an autosomal recessive manner.The basis of the disease is a mutation of the gene that codes for the enzyme glucocerebrosidase.The clinical division of GB into type 1, 2 and 3 …

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Indicators of stress hematopoiesis in the blood predict COVID-19 progression in patients over 65 years old

Miodrag Vučić, Jelena Milenković, Boris Djindjić, Vladana Stojiljković et autres

OBJECTIVES: Advanced age is a well-established risk factor for severe coronavirus disease 2019 (COVID-19). Exacerbated inflammation affects multiple organs, among which hematopoiesis responds by increased output of various cells. We aimed to determine the association between COVID-19 progression and large immature cell …

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Hodgkin transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma

Miodrag Vučić, Bozidar Lilic, Slavica Stojnev

Introduction. In rare cases, chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma may transform into Hodgkin lymphoma, with about a hundred cases reported in the literature so far. We present a case of the Hodgkin variant of Richter transformation. Case report. After a one-year …

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BLEEDING ASSESSMENT TOOLS

Miodrag Vučić, Sanja Veličković, Božidar Lilić

Bleeding Assessment Tools (BATs) are bleeding scoring systems used for screening and quantitative assessment of mild bleeding disorders.They consist of a standardized questionnaire and a scoring system that is used for the summation of the final score.In this review article, we have …

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Non-factor replacement therapy: A new chapter in hemophilia a prophylaxis

Miodrag Vučić, Božidar Lilić, Danijela Jovančić-Petković, Jelena Vučić

Hemophilia A is an antihemophilic factor deficiency which requires life-long treatment. The aim of this analysis was to present the effects of prophylactic non-factor replacement therapy in ten patients with hemophilia A. This retrospective analysis was conducted on ten male patients (4 …

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STEPS IN DIAGNOSIS OF CHRONIC IDIOPATHIC NEUTROPENIA: IS IT THE TIME FOR SERBIAN PATIENT REGISTRY?

Sanja Veličković, Miodrag Vučić, NIKOLA Z. STEFANOVIĆ, Filip Veličković et autres

Chronic neutropenia (CN) corresponds with absolute count of neutrophils below 1.8 × 10 9 /L in last three months.Besides, neutropenia that persists more than three months and in absence of underlying diseases, chemical components, irradiation, use of particular drugs, inflammation, is defined …

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Impact of quality of response on survival outcomes among multiple myeloma patients treated with novel agents – a retrospective analysis

Irena Ćojbašić, Miodrag Vučić, Ivan Tijanić, Žarko Ćojbašić

Abstract BACKGROUND: In this era of target therapies, novel data on the correlation between response endpoints and survival outcomes in multiple myeloma have arisen. OBJECTIVE: To determine the impact of quality of response on clinical outcomes, using first-line treatment, and identify risk …

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