Michael D. Buck

CXCR4 marks homeostatically activated dendritic cells in the steady state and in cancer

Mariana Pereira da Costa, Cécile Piot, Margarida Bonifacio, Victor Bosteels et autres

Conventional dendritic cells (cDCs) can be activated by pathogen signals and inflammation to drive T cell immunity to infection, but they can also undergo "homeostatic activation" at steady state. However, homeostatically activated cDCs closely resemble those activated by microbial or viral stimuli, …

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Coupling dead cell recognition to Fcγ receptors augments anticancer immunity

Tomas Castro‐Dopico, Cécile Piot, Michael D. Buck, Lucía Gandullo‐Sánchez et autres

Abstract Type 1 conventional dendritic cells (cDC1s) are key antigen-presenting cells (APCs) for cross-priming of CD8 + T cells against cancer. They can capture and cross-present dead cell antigens via DNGR-1 (CLEC9A), a receptor for F-actin exposed on cell corpses. However, cDC1s …

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Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity

Kok Haw Jonathan Lim, Oliver Schulz, Irene Lobón, Tomas Castro‐Dopico et autres

Type 1 conventional dendritic cells (cDC1s) acquire and cross-present tumor antigens to prime CD8⁺ T cells. Whether this selects for specific neoantigens is unclear. DNGR-1 (CLEC9A), a cDC1 receptor for F-actin exposed on dead cells, promotes cross-presentation of cell-associated antigens. Here we …

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MSR27 Analysis and Characterization of Variations in Conceptual and Operational Definitions for GLP-1 Agonist Treatment Eligibility for Weight Management

Jared H. Kamauu, Michael D. Buck, Amanda Shields, Craig G. Parker et autres

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RWD14 AI-Assisted Expert Computable Operation Definition (CODef) Development for Real-World Research

Michael D. Buck, Craig G. Parker, Aaron W. C. Kamauu

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DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation

Michael D. Buck, Tomas Castro‐Dopico, Oliver Schulz, Ana Cardoso et autres

Innate immune receptors often induce activation of conventional dendritic cells (cDCs) and enhance antigen (cross-)presentation, favouring immune responses. DNGR-1 (CLEC9A), a receptor expressed by type 1 cDCs (cDC1s) and implicated in immune responses to viruses and cancer, recognises F-actin exposed on dead …

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RWD6 COMPARATIVE ANALYSIS OF MEDICATION VALUE SETS ACROSS REFERENCE SOURCES TO ENSURE COMPLETE COVERAGE FOR REAL WORLD EVIDENCE STUDIES

Jared H. Kamauu, Aaron W. C. Kamauu, Craig G. Parker, Michael D. Buck

Objectives: As the world transitions into the endemic phase of COVID-19, a new challenge emerges: the long-term burden of illness among survivors.Health-related quality of life (HRQoL) outcomes remains poorly understood in low-and middleincome countries, where post-pandemic policy decisions lack localized evidence.This study …

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Spatial Organisation of Tumour cDC1 States Correlates with Effector and Stem‐Like CD8 + T Cells Location

Cécile Piot, Mariana Pereira da Costa, Adi Biram, Carlos M. Minutti et autres

ABSTRACT CD8 + T cells are central to targeting and eliminating cancer cells. Their function is critically supported by type 1 conventional dendritic cells (cDC1s), which both prime antigen‐specific CD8 + T cells in tumour‐draining lymph nodes (tdLNs) and sustain primed CD8 …

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RWD90 Analysis and Management of Computable Operational Definition (CODef) Concept Variation Based on a Large Real-World Studies Library

Michael D. Buck, Craig G. Parker, Aaron W. C. Kamauu

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MSR65 Development of Robust Comprehensive Code Lists to Ensure Consistency Across Global Real-World Evidence Studies

Aaron W. C. Kamauu, Craig G. Parker, Amanda Shields, Michael D. Buck

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Author response for "Spatial Organisation of Tumour cDC1 States Correlates with Effector and Stem-Like CD8+T Cells Location"

Cécile Piot, Mariana Pereira da Costa, Adi Biram, Carlos M. Minutti et autres

Author response for "Spatial Organisation of Tumour cDC1 States Correlates with Effector and Stem-Like CD8+T Cells Location"

Cécile Piot, Mariana Pereira da Costa, Adi Biram, Carlos M. Minutti et autres