RWD6 COMPARATIVE ANALYSIS OF MEDICATION VALUE SETS ACROSS REFERENCE SOURCES TO ENSURE COMPLETE COVERAGE FOR REAL WORLD EVIDENCE STUDIES

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Objectives: As the world transitions into the endemic phase of COVID-19, a new challenge emerges: the long-term burden of illness among survivors.Health-related quality of life (HRQoL) outcomes remains poorly understood in low-and middleincome countries, where post-pandemic policy decisions lack localized evidence.This study aimed to map the trajectory of HRQoL recovery in a large cohort of Malaysian COVID-19 survivors and identify key sociodemographic and clinical predictors-critical inputs for value-based post-COVID care and pandemic preparedness.Methods: A prospective cohort study involving 2,000 recovered patients was conducted in Selangor, Malaysia.HRQoL was assessed at three intervals-during infection, 3 months, and 6 months post-discharge, using EQ-5D-5L (utility values) and COVID-19-Quality of Life (disease-specific).The CO-19-QoL tool was culturally adapted and validated in accordance with the Professional Society for Health Economics and Outcomes Research (ISPOR) guidelines, demonstrating high internal consistency (Cronbach's α=0.919) and test-retest reliability (ICC=0.896).General Linear Models and repeated measures ANOVA were used to examine HRQoL changes and associated factors.Results: EQ-5D utility scores improved from 0.33 6 0.19 (baseline) to 0.54 6 0.20 (6 months; p,0.001), and EQ-VAS scores rose from 45.50 to 86.38.CO-19-QoL scores declined from 19.49 to 1.89, indicating reduced symptom burden.However, recovery was uneven.Poorer HRQoL trajectories were significantly associated with older age ($ 60), comorbidities, lower education, private sector employment, overweight BMI, smoking, and severe COVID-19 (Category 4).Socioeconomic disparities were evident; low-income patients (B40) experienced the slowest recovery (p,0.001).Conclusions: While overall HRQoL improved, vulnerable groups faced persistent deficits, highlighting the need for targeted post-COVID rehabilitation and equity-driven policies.EQ-5D-derived utility values lay the groundwork for cost-utility analyses and health technology assessments in Malaysia.These findings provide critical evidence for post-pandemic planning and reinforce the importance of integrating HRQoL into future emergency preparedness frameworks.

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