Accès ouvert
2025
preprint
OpenAlex
Magdalini Panagiotakopoulou, Kimon V. Argyropoulos, Anastasia I. Kousa, Kaitlyn Pierpont et autres
Kidney injury is a frequent and serious complication of allogeneic hematopoietic cell transplantation (HCT), yet its pathophysiology remains poorly understood and effective treatments are lacking. Through analysis of kidney tissue from HCT recipients, we identified substantial acute tubular injury and T cell …
us, fr
(code pays fourni par la source)
Accès ouvert
2025
conference-abstract
OpenAlex
Ya–Yuan Fu, Winston Chang, Anastasiya Ergorova, Alan M. Hanash
Abstract Interleukin-22 (IL-22) has been shown to promote epithelial regeneration, protect the intestinal stem cell (ISC) compartment from damage after allogeneic bone marrow transplantation, and reduce the severity of gastrointestinal graft vs. host disease (GI GVHD). The endogenous tissue-protective IL-22 response is …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Guillermo Ortí, Rachel Lorenc, Anastasiya Ergorova, Marco Calafiore et autres
Abstract Background Type 3 innate lymphoid cells (ILC3s) produce Interleukin-22 (IL-22) and contribute to epithelial maintenance and regeneration in the intestines. However, graft vs. host disease (GVHD) leads to ILC3 loss, impairing IL-22-driven intestinal regeneration. Post-transplant cyclophosphamide (PT-Cy) is administered to prevent …
us, es
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Susan DeWolf, Jason Kuttiyara, Paola Vinci, Teng Fei et autres
ABSTRACT: The bone marrow represents the tumor microenvironment for many hematologic malignancies and a potentially critical site for alloimmunity after hematopoietic transplantation. Despite the importance of immune reconstitution (IR) after transplant, marrow IR data are limited, and insights are largely derived from …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Ioannis Politikos, Samantha Brown, Joshua Alexander Fein, Stephen Eng et autres
ABSTRACT: Double-unit cord blood transplantation (dCBT) has been associated with high rates of progression-free survival (PFS) in adults with hematologic malignancies but also with relatively high rates of acute graft-versus-host disease (aGVHD). We conducted a single-arm, phase 2 clinical trial that investigated …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Winston Chang, Viktor Arnhold, Ya–Yuan Fu, Marco Calafiore et autres
Paneth cells (PCs) are a secretory epithelial population located in small intestine (SI) crypts. PCs produce growth factors within the intestinal stem cell (ISC) niche, including WNT3 , DLL1 and EGF, that maintain the intestinal epithelium . In murine models of acute …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Shuichiro Takashima, Roshan Sharma, Winston Chang, Marco Calafiore et autres
The role of the immune system in regulating tissue stem cells remains poorly understood, as does the relationship between immune-mediated tissue damage and regeneration. Graft vs. host disease (GVHD) occurring after allogeneic bone marrow transplantation (allo-BMT) involves immune-mediated damage to the intestinal …
us, jp, nl, lt
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Suze A. Jansen, Alessandro Cutilli, Coco C. H. de Koning, Marliek van Hoesel et autres
The intestine is vulnerable to chemotherapy-induced damage due to the high rate of intestinal epithelial cell (IEC) proliferation. We have developed a human intestinal organoid-based 3D model system to study the direct effect of chemotherapy-induced IEC damage on T cell behavior. Exposure …
nl, us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Viktor Arnhold, Winston Chang, Suze A. Jansen, Govindarajan Thangavelu et autres
Corticosteroid treatment (CST) failure is associated with poor outcomes for patients with gastrointestinal (GI) graft-versus-host disease (GVHD). CST is intended to target the immune system, but the glucocorticoid receptor (GR) is widely expressed, including within the intestines, where its effects are poorly …
us, nl, jp
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Toshihisa Satta, Esperanza Bouza Papadopoulos, Boglarka Gyurkocza, Pamela Susman et autres
Steroid-refractory (SR) gastrointestinal acute graft vs. host disease (GI aGVHD) remains a major complication of allogeneic hematopoietic transplantation. Ruxolitinib is the only FDA-approved therapy for SR aGVHD, and patients in whom ruxolitinib is ineffective or poorly tolerated have limited treatment options and …
us
(code pays fourni par la source)
2023
conference-abstract
OpenAlex
Toshihisa Satta, Esperanza Bouza Papadopoulos, Boglarka Gyurkocza, Pamela Susman et autres
Background: Steroid-refractory (SR) gastrointestinal acute GVHD (GI aGVHD) is a serious complication after allogeneic hematopoietic transplantation (allo-HCT), and subsequent lines of treatment following steroid failure are often ineffective. The JAK 1/2 inhibitor ruxolitinib is the only FDA-approved treatment for SR aGVHD, and …
jp, us
(code pays fourni par la source)
Accès ouvert
2023
conference-abstract
OpenAlex
Marco Calafiore, Ya–Yuan Fu, Paola Vinci, Viktor Arnhold et autres
Crypt base intestinal stem cells (ISCs) maintain the epithelial lining of the intestines, but their frequencies are reduced in experimental models of graft vs. host disease (GVHD). Paneth cells provide an epithelial contribution to the stem cell niche, but their frequencies are …
us, nl, jp, ch
(code pays fourni par la source)