Coco de Koning

Risk factors for alloimmune lung syndromes after allogeneic hematopoietic cell transplantation in children

Linde Dekker, Birgitta A. Versluys, Coco de Koning, Celina L. Szanto et autres

The non-infectious pulmonary complications idiopathic pneumonia syndrome (IPS) and bronchiolitis obliterans syndrome (BOS) are important causes of morbidity and mortality after allogeneic hematopoietic cell transplantation (allo-HCT). To identify risk factors for these complications, we retrospectively analyzed baseline characteristics and longitudinal data from …

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Identification of a plasma immune marker panel for early detection of acute graft-versus-host disease in children

Willemijn J. Klein Lebbink, Coco de Koning, Hannah Kunstek, Rana Dandis et autres

• Validation of the immune marker panel consisting of CCL17, galectin-1, and Reg3a shows 95% accuracy in predicting aGvHD grade II-IV. • The identified immune marker panel enables the development of an individualized approach in preventing and treating aGvHD in pediatric HCT. …

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Risk Factors for Alloimmune Lung Syndromes after Allogeneic Hematopoietic Cell Transplantation in Children

Coco de Koning, Linde Dekker, Birgitta Versluys, Celina L. Szanto et autres

nl, us (code pays fourni par la source)

Ex vivo T-lymphopoiesis assays assisting corrective treatment choice for genetically undefined T-lymphocytopenia

Zainab Golwala, Helena Spiridou Goncalves, Ranjita Devi Moirangthem, Grace Evans et autres

Thymic peptides in immune reconstitution and clinical outcome after allogeneic hematopoietic cell transplantation

Hannah Kunstek, Janneke Kieviet, Caroline A. Lindemans, Coco de Koning et autres

Patients with hematologic malignancies or nonmalignant diseases may undergo allogeneic hematopoietic cell transplantation (HCT), which represents a potential curative treatment. However, they are still at risk of life-threatening complications, such as relapse, acute graft-versus-host disease, and opportunistic infections. These complications are more …

nl (code pays fourni par la source)

Ex vivo T-lymphopoiesis assays assisting corrective treatment choice for genetically undefined T-lymphocytopenia

Zainab Golwala, Helena Spiridou Goncalves, Ranjita Devi Moirangthem, Grace Evans et autres

Persistent selective T-lymphocytopenia is found both in SCID and congenital athymia. Without molecular diagnosis, it is challenging to determine whether HCT or thymus transplantation ought to be performed. Ex vivo T-lymphopoiesis assays have been proposed to assist clinical decision-making for genetically undefined …

gb, ca, fr, nl, ch, be, at, au, dk, cz, it, il, es (code pays fourni par la source)

Thymic Peptides in Immune Reconstitution and Clinical Outcome after Allogeneic Hematopoietic Cell Transplantation

Hannah Kunstek, Janneke Kieviet, Caroline A. Lindemans, Coco de Koning et autres

Patients with hematologic malignancies or non-malignant diseases may undergo allogeneic hematopoietic cell transplantation (HCT), which represents a potential curative treatment. However, they are still at risk of life-threatening complications, such as relapse, acute graft-versus-host disease (GvHD), and opportunistic infections. These complications are …

nl (code pays fourni par la source)

Effect of clofarabine and fludarabine exposure on outcome after pediatric allogeneic hematopoietic cell transplantation

Linde Dekker, Coco de Koning, A. Laura Nijstad, Kim C. M. van der Elst et autres

Allogeneic hematopoietic cell transplantation (allo-HCT) is used as consolidation therapy in children with high-risk hematological malignancies.This curative treatment option comes with high morbidity and mortality.One of the critical challenges in improving clinical outcome is designing an effective conditioning regimen with limited toxicity.The …

nl, us (code pays fourni par la source)

Ex vivo T-lymphopoiesis assays assisting corrective treatment choice for genetically undefined T- lymphocytopaenia

Zainab Golwala, Helena Spiridou Goncalves, Ranjita Devi Moirangthem, Grace Evans et autres

gb, fr, nl, be, sk, au, dk, cz, il, ch, br (code pays fourni par la source)

Prophylactic use of liposomal amphotericin B in children and adolescents undergoing allogeneic hematopoietic cell transplantation: A 10-years single center experience

Laura G.Y. Rotte, Coco de Koning, Yvette G.T. Loeffen, Marc Bierings et autres

Background Azoles are recommended as antifungal prophylaxis in decreasing the incidence of invasive fungal disease (IFD) in high-risk patients in pediatric oncology, including patients receiving allogeneic hematopoietic cell transplantation (HCT). However, azole related toxicity, pharmacological interactions with immunosuppressive medication and conditioning regimen …

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Chemotherapy-induced intestinal epithelial damage directly promotes galectin-9-driven modulation of T cell behavior

Suze A. Jansen, Alessandro Cutilli, Coco de Koning, Marliek van Hoesel et autres

The intestine is vulnerable to chemotherapy-induced damage due to the high rate of intestinal epithelial cell (IEC) proliferation. We have developed a human intestinal organoid-based 3D model system to study the direct effect of chemotherapy-induced IEC damage on T cell behavior. Exposure …

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Real World Use of the Pediatric Disease Risk Index for Allogeneic Hematopoietic Cell Transplantation in Patients with Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia: A Multicenter Study

A. Lucas, Senthil Velan Bhoopalan, Stefan Nierkens, Coco de Koning et autres

To determine the risk of relapse of hematologic malignancies after allogeneic hematopoietic cell transplantation (allo-HCT), a disease risk index (DRI) tool has been used extensively for adult patients. In 2021 a validated DRI, considering age and disease status, for pediatric patients was …

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