Accès ouvert
2026
preprint
OpenAlex
Megan O’Brien, Bradie Ahern, Piper Brase, Sooyeol Kim et autres
Abstract Antimicrobial resistance (AMR) is a pressing global public health challenge. AMR is driven in part by the spread of antibiotic resistance genes (ARGs) through bacterial communities via mobile genetic elements. Influent wastewater is a promising sample type for monitoring AMR because …
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Accès ouvert
2026
article
OpenAlex
Angelo O. Ong, Briahna Koger, Bradie Ahern, Megan O’Brien et autres
Abstract Wastewater-based epidemiology for sexually transmitted pathogens Chlamydia trachomatis (chlamydia), Neisseria gonorrhoeae (gonorrhea), and Treponema pallidum (syphilis) is sparse compared to viral targets despite their public health significance. We used multiplex, digital PCR to characterize C. trachomatis, Neisseria gonorrhoeae, and T. pallidum …
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Accès ouvert
2025
article
OpenAlex
Sooyeol Kim, Denise I. Garcia, Caroline McCormack, Rui Xin Tham et autres
High Resolution Image Download MS PowerPoint Slide Effective methods for simultaneously measuring viral, bacterial, protozoan, and fungal pathogens in wastewater are needed. Here, we investigate how the sample type and nucleic acid extraction protocols affect broad-range pathogen detection. We compared methods for …
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Accès ouvert
2025
preprint
OpenAlex
Sooyeol Kim, Denise I. Garcia, Caroline McCormack, Rui Xin Tham et autres
Abstract Effective methods for simultaneously measuring viral, bacterial, protozoan, and fungal pathogens in wastewater are needed. Here, we investigate how sample type and nucleic acid extraction protocols affect broad-range pathogen detection. We compared methods for analyzing wastewater solids and whole influent by …
us
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Accès ouvert
2025
article
OpenAlex
Megan O’Brien, Alen Marijam, Fanny S Mitrani-Gold, L Terry et autres
Uncomplicated urinary tract infections (uUTIs) represent a sizable healthcare burden with a substantial negative impact on patients' health-related quality-of-life (HRQoL). However, the HRQoL impact of uUTI from the patient perspective is under-represented in research. A cross-sectional online survey assessed activity impairment and …
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Accès ouvert
2024
article
OpenAlex
Ema Mujic, Samantha E. Parker, Kerrie P. Nelson, Megan O’Brien et autres
BACKGROUND: Postpartum hypertension is a risk factor for severe maternal morbidity; however, barriers exist for diagnosis and treatment. Remote blood pressure (BP) monitoring programs are an effective tool for monitoring BP and may mitigate maternal health disparities. We aimed to describe and …
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2021
article
OpenAlex
Darwin Ang, Kenny Nieto, Mason Sutherland, Megan O’Brien et autres
BACKGROUND: Patient safety indicators (PSIs) are avoidable complications that can impact outcomes. Geriatric patients have a higher mortality than younger patients with similar injuries, and understanding the etiology may help reduce mortality. We aim to estimate preventable geriatric trauma mortality in the …
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Accès ouvert
2021
article
OpenAlex
Megan O’Brien, Alen Marijam, Fanny S Mitrani-Gold, L Terry et autres
Abstract Background Uncomplicated urinary tract infections (uUTI) are one of the most common bacterial infections in women. Understanding unmet needs of physicians in diverse healthcare systems is important for developing novel uUTI treatment (tx). Methods A cross-sectional survey of physicians in the …
gb, us
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2017
article
OpenAlex
Megan O’Brien, Janet H. Ford, Sheena K. Aurora, Sriram Govindan et autres
BACKGROUND: Cluster headache (CH) is a primary headache disorder associated with low levels of diagnosis and high unmet medical need. The pain attacks, associated anxiety, and fear in anticipation of the attacks are extremely debilitating to a patient with CH. For acute …
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2014
article
OpenAlex
Sabrina Guse, Mark I. Neuman, Megan O’Brien, Mark E. Alexander et autres
BACKGROUND AND OBJECTIVES: Thirty-five percent of children experience syncope at least once. Although the etiology of pediatric syncope is usually benign, many children undergo low-yield diagnostic testing. We conducted a quality improvement intervention to reduce the rates of low-yield diagnostic testing for …
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