Protein catabolites as blood-based biomarkers of aging physiology: Findings from the Dog Aging Project
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Le résumé fourni par la source
Our understanding of age-related physiology and metabolism has grown through the study of systems biology, including transcriptomics, single-cell analysis, proteomics and metabolomics. Studies in lab organisms in controlled environments, while powerful and complex, fall short of capturing the breadth of genetic and environmental variation in nature. Thus, there is now a major effort in geroscience to identify aging biomarkers and to develop aging interventions that might be applied across the diversity of humans and other free-living species. To meet this challenge, the Dog Aging Project (DAP) is designed to identify cross-sectional and longitudinal patterns of aging in complex systems, and how these are shaped by the diversity of genetic and environmental variation among companion dogs. Here we surveyed the plasma metabolome from the first year of sampling of the Precision Cohort of the DAP. By incorporating extensive metadata and whole genome sequencing information, we were able to overcome the limitations inherent in breed-based estimates of genetic and physiological effects, and to probe the physiological and dietary basis of the age-related metabolome. We identified a significant effect of age on approximately 40% of measured metabolites. Among other insights, we discovered a potentially novel biomarker of age in the post-translationally modified amino acids (ptmAAs). The ptmAAs, which can only be generated by protein hydrolysis, covaried both with age and with other biomarkers of amino acid metabolism, and in a way that was robust to diet. Clinical measures of kidney function mediated about half of the higher ptmAA levels in older dogs. This work identifies ptmAAs as robust indicators of age in dogs, and points to kidney function as a physiological mediator of age-associated variation in the plasma metabolome.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Protein catabolites as blood-based biomarkers of aging physiology: Findings from the Dog Aging Project
- Date Crossref
- 21/10/2024
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Washington Department of Laboratory Medicine and Pathology pays non établi dans la noticeUniversité ou école supérieure
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University of Utah pays non établi dans la noticeUniversité ou école supérieure
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Arizona State University pays non établi dans la noticeUniversité ou école supérieure
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Tel Aviv University Department of Clinical Microbiology and Immunology pays non établi dans la noticeUniversité ou école supérieure
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Texas A&M University Department of Small Animal Clinical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Colorado State University pays non établi dans la noticeUniversité ou école supérieure
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Tufts University Jean Mayer USDA Human Nutrition Research Center on Aging pays non établi dans la noticeUniversité ou école supérieure
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Jean Mayer Human Nutrition Research Center on Aging pays non établi dans la noticeOrganisme public
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School of Life Sciences pays non établi dans la noticeUniversité ou école supérieure
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Blavatnik School of Computer Science pays non établi dans la noticeUniversité ou école supérieure
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Texas A and M University College of Veterinary Medicine and Biomedical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medical & Health Sciences pays non établi dans la noticeUniversité ou école supérieure
Department of Laboratory Medicine and Pathology — University of Washington, University of Utah et Arizona State University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.