Carmela Cacciapuoti

The natural phosphoinositide derivative glycerophosphoinositol inhibits the lipopolysaccharide-induced inflammatory and thrombotic responses

Mariangela Vessichelli, Stefania Mariggiò, Alessia Varone, Pasquale Zizza et autres

synthesis of proinflammatory and prothrombotic compounds and might thus have a role as an endogenous mediator in the resolution of inflammation. As indicated, this effect of glycerophosphoinositol can also be exploited in the treatment of manifestations of severe inflammation by exogenous administration …

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Hepatitis C virus (HCV) genotypes distribution: an epidemiological up-date in Europe

Arnolfo Petruzziello, Samantha Marigliano, Giovanna Loquercio, Carmela Cacciapuoti

Hepatitis C virus (HCV) infection is a major public health burden in Europe, causing an increasing level of liver-related morbidity and mortality, characterized by several regional variations in the genotypes distribution. A comprehensive review of the literature from 2000 to 2015 was …

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Autologous Platelet Gel Improves Bone Reconstruction of Large Defects in Patients with Bone Giant Cell Tumors.

Giovanna Loquercio, Gaetano Di Costanzo, Flavio Fazioli, Michele Gallo et autres

BACKGROUND/AIM: Giant cell tumors are mostly benign but locally aggressive tumors. The excision of bone tumors can result in large defects, therefore bone reconstruction is still one the most demanding procedures in orthopedic surgery. Our study addresses the opportunity for improving surgical …

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Hepatitis C Virus (HCV) genotype 1b as a risk factor for hepatocellular carcinoma development in chronic HCV positive patients in Southern Italy

Arnolfo Petruzziello Marigliano S Loquercio G Guarino R Izzo F, Carmela Cacciapuoti

Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes

Arnolfo Petruzziello, Samantha Marigliano, Giovanna Loquercio, Anna Cozzolino et autres

AIM: To review Hepatitis C virus (HCV) prevalence and genotypes distribution worldwide. METHODS: We conducted a systematic study which represents one of the most comprehensive effort to quantify global HCV epidemiology, using the best available published data between 2000 and 2015 from …

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Abstract 426: Targeting CXCR4 reduced T regulatory cells (Tregs) -mediated cell proliferation suppression in renal cell carcinoma (RCC) patients

Sara Santagata, Maria Napolitano, Crescenzo D’Alterio, Sabrina Chiara Cecere et autres

Abstract Introduction: Renal cell carcinoma (RCC) is an immunogenic cancer with specimens containing tumor infiltrating lymphocytes. T regulatory cells CD4+CD25+Foxp3+ (Tregs) accumulate in RCC and have been implicated in tumor immune escape. Since the chemokine receptor axis CXCR4/CXCL12/CXCR7 plays a crucial role …

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Use of allogeneic platelet gel in the management of chemotherapy extravasation injuries: a case report

Giovanna Loquercio, Gaetano Di Costanzo, Gianpaolo Marcacci, Vincenzo Iervolino et autres

The allogeneic platelet (PLT) gel offers to be a valid supportive measure in the management of chemotherapy extravasation injuries. We report a case of a 58-year-old patient with multiple myeloma enrolled for high-dose chemotherapy and autologous stem cell transplantation. As pretransplant therapy, …

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Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients

Maria Napolitano, Crescenzo D’Alterio, E. Cardone, Anna Maria Trotta et autres

// Maria Napolitano 1 , Crescenzo D’Alterio 1 , Eleonora Cardone 2 , Anna Maria Trotta 1 , Biagio Pecori 3 , Daniela Rega 2 , Ugo Pace 2 , Dario Scala 2 , Giosuè Scognamiglio 4 , Fabiana Tatangelo 4 , …

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Erratum

Takeshi Azuma, Yoshihiko Yano, Didik Setyo Heriyanto, Takako Utsumi et autres

Distribution Pattern of Hepatitis C Virus Genotypes and Correlation with Viral Load and Risk Factors in Chronic Positive Patients

Arnolfo Petruzziello, Nicola Coppola, Giovanna Loquercio, Samantha Marigliano et autres

OBJECTIVE: Hepatitis C virus (HCV) has emerged as a leading cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma worldwide. The purpose of this study was to describe the distribution pattern of HCV genotypes in chronic hepatitis patients in the Campania region …

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Systems biology analysis of immune signaling in peripheral blood mononuclear cells (PBMC) of melanoma patients receiving ipilimumab; basis for response biomarker identification

Drew Hotson, Ryan Alvarado, Andy Conroy, Santosh Putta et autres

Ipilimumab, an anti-CTLA-4 monoclonal antibody, is approved for treatment of unresectable/metastatic melanoma [ 1 ]. Treatment benefits only a subset of patients (pts) and is associated with significant adverse effects. Biomarkers of pt response are needed. Single cell network profiling (SCNP) is …

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HBV transmission from an occult carrier with five mutations in the major hydrophilic region of HBsAg to an immunosuppressed plasma recipient

Nicola Coppola, Giovanna Loquercio, Gilda Tonziello, Rosa Azzaro et autres

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