Jorge Arrubla

Dual Glucagon and GLP ‐1 Receptor Agonist Survodutide Improves Biomarkers of Beta‐Cell Function and Insulin Sensitivity in People With Type 2 Diabetes or Living With Overweight/Obesity

Elif Ilhan Ekinci, Sandra González Maldonado, Anna Unseld, Jorge Arrubla et autres

AIMS: This post hoc analysis evaluated the effect of survodutide on beta-cell function, insulin sensitivity, and glucose biomarkers in two phase 2 trial populations. MATERIALS AND METHODS: Trial 1404-0002 randomised 413 participants with type 2 diabetes on metformin to receive survodutide, placebo, …

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Ultra rapid lispro (Lyumjev®) shortens time to recovery from hyperglycaemia compared to Humalog® in individuals with type 1 diabetes on continuous subcutaneous insulin infusion

Jennifer K. Leohr, Mary Anne Dellva, Elizabeth Smith LaBell, David E. Coutant et autres

Abstract Aims To compare the time to hyperglycaemia recovery after ultra rapid lispro (URLi; Lyumjev®) versus Humalog in a randomized, double‐blind crossover study. Materials and Methods Thirty‐two adults with type 1 diabetes on continuous subcutaneous insulin infusion participated in two periods: each …

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Phase I studies of the safety, tolerability, pharmacokinetics and pharmacodynamics of the dual glucagon receptor/glucagon‐like peptide‐1 receptor agonist BI 456906

Arvid Jungnik, Jorge Arrubla, Leona Plum‐Mörschel, Christoph Kapitza et autres

Abstract Aim To report two phase I studies of the novel subcutaneous glucagon‐like peptide‐1 receptor/glucagon receptor (GLP‐1R/GCGR) dual agonist BI 456906 versus placebo in healthy volunteers and people with overweight/obesity. Materials and Methods A phase Ia study (NCT03175211) investigated single rising doses …

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Author response for "Phase I studies of the safety, tolerability, pharmacokinetics and pharmacodynamics of the dual glucagon receptor/glucagon‐like peptide‐1 receptor ( GCGR / GLP‐1R ) agonist BI 456906"

Arvid Jungnik, Jorge Arrubla, Leona Plum‐Mörschel, Christoph Kapitza et autres

Faster Recovery from Hyperglycemia with Ultra Rapid Lispro (URLi) vs Insulin Lispro in Patients with Type 1 Diabetes (T1D) on Continuous Subcutaneous Insulin Infusion (CSII)

Jennifer K. Leohr, Mary Anne Dellva, Elizabeth Smith LaBell, Zhentao Tong et autres

Background and aims Ultra Rapid Lispro (URLi) is a novel insulin lispro formulation developed to more closely match physiological insulin secretion. aim of the study was to assess the time of recovery from hyperglycemia following administration of URLi compared to Lispro. Methods …

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190-OR: Faster Recovery from Hyperglycemia with Ultrarapid Lispro (URLi) vs. Humalog in Patients with Type 1 Diabetes (T1D) on Continuous Subcutaneous Insulin Infusion (CSII)

Jennifer K. Leohr, Elizabeth Smith LaBell, Mary Anne Dellva, Zhentao Tong et autres

URLi is a novel insulin lispro formulation developed to more closely match physiological insulin secretion. This randomized, double-blind, 2-period, crossover study compared pharmacokinetics and glucodynamics of URLi vs. Humalog during recovery from hyperglycemia (plasma glucose [PG] >240 mg/dL) due to missed meal …

Endothelial‐protective effects of a G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist, SAR247799, in type‐2 diabetes rats and a randomized placebo‐controlled patient trial

Luc Bergougnan, Grit Andersen, Leona Plum‐Mörschel, Maria Francesca Evaristi et autres

Aims SAR247799 is a G‐protein‐biased sphingosine‐1 phosphate receptor‐1 (S1P 1 ) agonist designed to activate endothelial S1P 1 and provide endothelial‐protective properties, while limiting S1P 1 desensitization and consequent lymphocyte‐count reduction associated with higher doses. The aim was to show whether S1P …

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Endothelial-protective effects of a G-protein-biased sphingosine-1 phosphate receptor-1 agonist, SAR247799, in type-2 diabetes rats and a randomized placebo-controlled patient trial.

Luc Bergougnan, Grit Andersen, Maria Francesca Evaristi, Bruno Poirier et autres

SAR247799 is a G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1) agonist designed to activate endothelial S1P1 and provide endothelial-protective properties, while limiting S1P1 desensitization and consequent lymphocyte-count reduction associated with higher doses. A dose-response study in diabetic rats with 5-week SAR247799 treatment demonstrated, at …

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BioChaperone Lispro versus faster aspart and insulin aspart in patients with type 1 diabetes using continuous subcutaneous insulin infusion: A randomized euglycemic clamp study

Tim Heise, Grégory Meiffren, Bertrand Alluis, Cyril Seroussi et autres

We investigated the pharmacodynamics (PD) and pharmacokinetics (PK) of BioChaperone insulin Lispro (BCLIS), faster insulin aspart (FIA) and insulin aspart (ASP) in patients with type 1 diabetes using an insulin pump. In this randomized, double‐blind, three‐way crossover glucose clamp study, 43 patients …

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The Ultra-rapid Insulin (URI) BioChaperone Lispro (BCLIS) Shows Favorable Pharmacodynamics (PD) and Pharmacokinetics (PK) vs. Faster Aspart (FIA) and Insulin Aspart (ASP) in Insulin Pumps (CSII)

Bruce W. Bode, Oliver Klein, Cyril Seroussi, Aymeric Ranson et autres

This double-blind randomized crossover trial is the first to compare the PD and PK properties of two URIs (BCLIS and FIA) and of a conventional analog (ASP). Forty-three patients with type 1 diabetes received a bolus of 0.15 U/kg of BCLIS, FIA …

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Multimodal Fingerprints of Resting State Networks as assessed by Simultaneous Trimodal MR-PET-EEG Imaging

Nadim Jon Shah, Jorge Arrubla, Ravichandran Rajkumar, Ezequiel Farrher et autres

Abstract Simultaneous MR-PET-EEG (magnetic resonance imaging - positron emission tomography – electroencephalography), a new tool for the investigation of neuronal networks in the human brain, is presented here for the first time. It enables the assessment of molecular metabolic information with high …

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Microstructural and functional correlates of glutamate concentration in the posterior cingulate cortex

Jorge Arrubla, Ezequiel Farrher, Johanna Strippelmann, Desmond H. Y. Tse et autres

Glutamate is the major excitatory neurotransmitter in the human brain and has a central role in both intrinsic and stimulus-induced activity. We conducted a study in a cohort of healthy, male volunteers in which glutamate levels were measured in the posterior cingulate …

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