Chitra K. Karki

Is Cyanosis Exposure Associated with Exercise Capacity or Daily Physical Activity in Children with Complex Congenital Heart Disease: A Cross-Sectional Study

Chitra K. Karki, Tyler Kung, Joël Blanchard, Jane Lougheed et autres

Background/Objectives: Children with complex congenital heart disease (CHD) often exhibit lower levels of physical activity, but whether chronic cyanosis exposure is associated with activity participation is unclear. This cross-sectional study investigated whether the duration of cyanosis prior to surgical correction was associated …

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SAT-401 Liver disease progression in patients with alpha-1 antitrypsin deficiency and a Pi*ZZ genotype: a retrospective natural history study

Virginia Clark, May Hagiwara, Jeanine M D'Armiento, Monica P. Goldklang et autres

SAT-400 Estimating the diagnosis rate of alpha-1 antitrypsin deficiency: insights from population-based cohorts in the USA

Grahame F. Evans, Xinruo Zhang, Jennifer Elizabeth Below, Kari E. North et autres

Patient experience of alpha-1 antitrypsin deficiency-associated liver disease: a qualitative study

Virginia Clark, Suna Park, Robert N. Krupnick, Nicole Sparling et autres

PURPOSE: To elicit the signs and/or symptoms, and impacts on daily living experienced by patients with alpha-1 antitrypsin deficiency-associated liver disease (AATD-LD). METHODS: A preliminary "concept list" of signs and/or symptoms, and impacts was developed from a targeted literature review, patient blog …

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Predictive modeling to evaluate long-term treatment effectiveness of darvadstrocel in patients with complex perianal fistulas in Crohn’s disease

Chitra K. Karki, Gary L. Hantsbarger, Erika Turkstra, Elisabetta Fenu et autres

BACKGROUND: Current therapies for complex Crohn's perianal fistulas (CPF) have a limited ability to achieve long-term healing. Darvadstrocel (DVS) is an expanded allogeneic adipose-derived mesenchymal stem cell therapy that has demonstrated efficacy in treating complex CPF in clinical trials. There are, however, …

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Impact of Seton Use on Clinical, Patient-Reported, and Healthcare Resource Utilization Outcomes in Complex Crohn’s Perianal Fistulas: A Systematic Literature Review

Ian D. White, Chitra K. Karki, Parnia Geransar, L Leisle et autres

BACKGROUND: Optimal treatment strategies for seton use in patients with Crohn's perianal fistulas (CPF) remain elusive. This systematic literature review aimed to summarize clinical, patient-reported, and healthcare resource utilization (HCRU) outcomes associated with seton use for symptomatic relief and treatment of complex …

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Development of a new patient-reported outcome measure for complex cryptoglandular fistulas (20-Item complex cryptoglandular fistula questionnaire™): a qualitative study

Jeffrey D. McCurdy, Patrick Crooks, Chad J. Gwaltney, Robert N. Krupnick et autres

Abstract Background There are limited tools to measure the burden of disease and effectiveness of medical/surgical interventions in patients with cryptoglandular fistulas. The aim of this study was to explore concepts that are relevant and important to patients with complex cryptoglandular fistulas …

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Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn’s perianal fistulas

Chitra K. Karki, Amod S. Athavale, Vijay Abilash, Gary L. Hantsbarger et autres

BACKGROUND Patients with Crohn’s disease (CD) are at risk of developing complications such as perianal fistulas. Patients with Crohn’s perianal fistulas (CPF) are affected by fecal incontinence (FI), bleeding, pain, swelling, and purulent perianal discharge, and generally face a higher treatment burden …

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Liver disease epidemiology and burden in patients with alterations in plasma protein metabolism: German retrospective insurance claims analysis

Nils Picker, May Hagiwara, Severin Baumann, Ed G. Marins et autres

Patients with liver cirrhosis are advised to limit their sodium consumption to control excessive fluid accumulation. Salt is the most common form in which sodium is consumed daily. Consequently, various recommendations urge patients to limit salt intake. However, there is a lack …

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Liver disease progression in patients with alpha‐1 antitrypsin deficiency and protease inhibitor ZZ genotype with or without lung disease

Tiffany E. Wu, May Hagiwara, Esteban D Gnass, Hannah Barman et autres

BACKGROUND: Alpha-1 antitrypsin deficiency (AATD) is caused by mutations in SERPINA1, which encodes alpha-1 antitrypsin, a protease inhibitor (Pi). Individuals with AATD and the homozygous Pi*ZZ genotype have variable risk of progressive liver disease but the influence of comorbid lung disease is …

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Disease Burden, Treatment Patterns, and Economic Impact of Rectovaginal Fistulas in Patients with Crohn’s Disease: Findings from a Retrospective, Observational, Longitudinal Study Based on US Claims Databases

Chitra K. Karki, Dominick Latrémouille-Viau, Inmaculada Gilaberte, Gary L. Hantsbarger et autres

BACKGROUND: Crohn's-related rectovaginal fistulas (RVF) greatly impact quality of life and are notoriously difficult to treat. The aim of this study was to assess the burden of recurrent episodes of care for RVF and its economic impact. METHODS: A retrospective observational cohort …

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Epidemiology, Disease Course, and Clinical Outcomes of Perianal Fistulas and Fissures Crohn’s Disease: A Nationwide Population-Based Study in Taiwan

Meng‐Tzu Weng, Kuan-Lin Lin, Ya‐Ling Huang, Chitra K. Karki et autres

Abstract Background Population-based data on the course of perianal disease in East Asian populations with Crohn’s disease (CD) are limited. This study examined the prevalence, clinical course, and compared the outcomes of CD patients with perianal CD (pCD) versus without pCD in …

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