Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn’s perianal fistulas
Rattachement africain : us, jp, ch, ca, au, gb, be. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND Patients with Crohn’s disease (CD) are at risk of developing complications such as perianal fistulas. Patients with Crohn’s perianal fistulas (CPF) are affected by fecal incontinence (FI), bleeding, pain, swelling, and purulent perianal discharge, and generally face a higher treatment burden than patients with CD without CPF. AIM To gain insights into the burden of illness/quality of life in patients with CPF and their treatment preferences and satisfaction. METHODS This cross-sectional observational study was conducted in patients with CD aged 21-90 years via a web-enabled questionnaire in seven countries (April-August 2021). Patients were recruited into three cohorts: Cohort 1 included patients without perianal fistulas; cohort 2 included patients with perianal fistulas without fistula-related surgery; and cohort 3 included patients with perianal fistulas and fistula-related surgery. Validated patient-reported outcome measures were used to assess quality of life. Drivers of treatment preferences were measured using a discrete choice experiment (DCE). RESULTS In total, 929 patients were recruited (cohort 1, n = 620; cohort 2, n = 174; cohort 3, n = 135). Short Inflammatory Bowel Disease Questionnaire scores were worse for patients with CPF (cohorts 2 and 3) than for those with CD without CPF (cohort 1): Mean score 3.8 and 3.7 vs 4.1, respectively, (P < 0.001). Similarly, mean Revised FI and FI Quality of Life scores were worse for patients with CPF than for those with CD without CPF. Quality of Life with Anal Fistula scores were similar in patients with CPF with or without CPF-related surgery (cohorts 2 and 3): Mean score 41 and 42, respectively. In the DCE, postoperative discomfort and fistula healing rate were the most important treatment attributes influencing treatment choice: Mean relative importance 35.7 and 24.7, respectively. CONCLUSION The burden of illness in CD is significantly higher for patients with CPF and patients rate lower postoperative discomfort and higher healing rates as the most desirable treatment attributes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn’s perianal fistulas
- Date Crossref
- 27/11/2023
- Éditeur
- Baishideng Publishing Group Inc.
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
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Takeda (United States) pays non établi dans la noticeEntreprise
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Takeda (Japan) pays non établi dans la noticeEntreprise
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Takeda (Switzerland) pays non établi dans la noticeEntreprise
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Crohn's and Colitis Canada pays non établi dans la noticeOrganisation à but non lucratif
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Crohn's & Colitis Australia pays non établi dans la noticeOrganisation à but non lucratif
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Takeda (United States), Takeda (Japan) et Takeda (Switzerland), avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.