Xinruo Zhang

Paediatric proteomic signatures of cardiometabolic disease-associated traits predict adult disease outcomes

Joshua M. Landman, Heather M. Highland, Andrew Perry, Annie Green Howard et autres

While the earliest pathological signs of cardiovascular-kidney-metabolic disease (CKMD) emerge before age 20, current adult-based risk thresholds fail to identify a substantial fraction of children at high risk. With increasing childhood obesity, early, sensitive detection of CKMD risk is critical to timely …

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Multi-omic characterization of the Hispanic/Latino blood lipidome reveals an additional locus and attenuated genetic prediction

Hung‐Hsin Chen, Mohammad Y Anwar, Penny Gordon-Larsen, Joanne E. Curran et autres

us (code pays fourni par la source)

Multi-omic characterization of the Hispanic/Latino blood lipidome reveals an additional locus and attenuated genetic prediction

Wanying Zhu, Hung‐Hsin Chen, Heather M. Highland, Corey Giles et autres

While lipids have been extensively investigated, genetic regulation of the circulating lipidome in diverse populations remains poorly understood. We conducted a lipidome-wide genome-wide association study (GWAS) of 830 lipid species in 2,287 Hispanic/Latino participants and performed predictive modeling across omics layers. We …

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Alterations in DNA Methylation, Proteomic, and Metabolomic Profiles in African Ancestry Populations with APOL1 Risk Alleles.

Holly Kramer, Julian Avila, Victoria L. Buchanan, Stephen S Rich et autres

BACKGROUND: The APOL1 high-risk haplotype has been associated with chronic kidney disease (CKD) and the deterioration of kidney function, particularly in populations with West African ancestry. However, the mechanisms by which APOL1 risk variants increase the risk for kidney disease and its …

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Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM

Ravi V. Shah, Hannah G. Polikowsky, Mariaelisa Graff, Eric R. Gamazon et autres

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Multi-omic characterization of the Hispanic/Latino blood lipidome reveals a new locus and attenuated genetic prediction (summary statistics, part4)

Wanying Zhu, Hung‐Hsin Chen, Heather M. Highland, Corey Giles et autres

tw, au, us (code pays fourni par la source)

Multi-omic characterization of the Hispanic/Latino blood lipidome reveals a new locus and attenuated genetic prediction (summary statistics, part4)

Wanying Zhu, Hung‐Hsin Chen, Heather M. Highland, Corey Giles et autres

tw, au, us (code pays fourni par la source)

Multi-omic characterization of the Hispanic/Latino blood lipidome reveals a new locus and attenuated genetic prediction (summary statistics, part3)

Wanying Zhu, Hung‐Hsin Chen, Heather M. Highland, Corey Giles et autres

tw, au, us (code pays fourni par la source)

Multi-omic characterization of the Hispanic/Latino blood lipidome reveals a new locus and attenuated genetic prediction (summary statistics, part3)

Wanying Zhu, Hung‐Hsin Chen, Heather M. Highland, Corey Giles et autres

tw, au, us (code pays fourni par la source)

Multi-omic characterization of the Hispanic/Latino blood lipidome reveals a new locus and attenuated genetic prediction (summary statistics, part1)

Wanying Zhu, Hung‐Hsin Chen, Heather M. Highland, Corey Giles et autres

tw, au, us, gb (code pays fourni par la source)

Multi-omic characterization of the Hispanic/Latino blood lipidome reveals a new locus and attenuated genetic prediction (summary statistics, part1)

Wanying Zhu, Hung‐Hsin Chen, Heather M. Highland, Corey Giles et autres

tw, au, us, gb (code pays fourni par la source)

Multi-omic characterization of the Hispanic/Latino blood lipidome reveals a new locus and attenuated genetic prediction (summary statistics, part2)

Wanying Zhu, Hung‐Hsin Chen, Heather M. Highland, Corey Giles et autres

tw, au, us (code pays fourni par la source)